Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Crystal G. Bashore"'
Autor:
Sebastien Demers, John Candler, Jotham Wadsworth Coe, Crystal G. Bashore, Eric P. Arnold, Heather Stevenson, Brian T. O’Neill
Publikováno v:
Tetrahedron Letters. 49:3368-3371
A series of bicyclic pyridine containing alkaloids related to (−)-cytisine and varenicline are described. Synthetic access via regioisomeric metalation of alkoxy- and halo-pyridines gains entry to all four isomeric [3.3.1]-bicyclic targets. Regiose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd20dd2e54f3a975ae2018395edfcc80
https://doi.org/10.1016/j.tetlet.2008.03.133
https://doi.org/10.1016/j.tetlet.2008.03.133
Autor:
Thomas I. Davis, Carol B. Fox, Michael C. Wirtz, Michael G. Vetelino, F. David Tingley, Krista E. Bianco, Robert S. Mansbach, David W. Schulz, Jotham Wadsworth Coe, Crystal G. Bashore, Hans Rollema, Eric P. Arnold, Paige Roanne Palmer Brooks, Steven B. Sands, Brian T. O’Neill, Lorraine A. Lebel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4889-4897
3,5-Bicyclic aryl piperidines are a new class of high-affinity alpha4beta2 nicotinic receptor agents. We have sought nicotinic receptor partial agonists of the alpha4beta2 nicotinic acetylcholine receptor for smoking cessation, and a number of compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04dfd8d682666f8daba933d872fb0b4a
https://doi.org/10.1016/j.bmcl.2005.08.035
https://doi.org/10.1016/j.bmcl.2005.08.035
Autor:
Teresa W. Makowski, Ruth E. McDermott, Paige Roanne Palmer Brooks, Michael C. Wirtz, Crystal G. Bashore, Michael G. Vetelino, John A. Ragan, David C. Whritenour, Jotham Wadsworth Coe, Heather N. Frost, Steven J. Brenek, Jennifer Lea Rutherford
Publikováno v:
Organic letters. 8(26)
[Structure: see text] The development of a concise enantioselective synthesis of nicotinic alkaloid 1 is presented. The route features the synthesis and use of a "stable" aliphatic triflate 21 in an alkylation step to generate Heck precursor 24 and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80965a90b4448a18d3169e58916042b
https://pubmed.ncbi.nlm.nih.gov/17165901
https://pubmed.ncbi.nlm.nih.gov/17165901
Autor:
Michael C. Wirtz, Eric P. Arnold, Paige Roanne Palmer Brooks, Michael G. Vetelino, Lorraine A. Lebel, Carol B. Fox, David W. Schulz, Brian T. O’Neill, Crystal G. Bashore, Jotham Wadsworth Coe, Thomas I. Davis, Hans Rollema, Steven B. Sands, F. David Tingley
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(12)
The preparation and biological activity of analogs of (-)-cytisine, an alpha4beta2 nicotinic receptor partial agonist, are discussed. All-carbon-containing phenyl ring replacements of the pyridone ring system, generated via Heck cyclization protocols
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270e8e92215b8f7670e12bf1597706a0
https://pubmed.ncbi.nlm.nih.gov/15908213
https://pubmed.ncbi.nlm.nih.gov/15908213
Autor:
David B. Collum, Antonio Ramirez, Jotham Wadsworth Coe, Michael C. Wirtz, John Candler, Crystal G. Bashore
Publikováno v:
Journal of the American Chemical Society. 126(45)
The key elimination step for the formation of 3-chloro- and 3-fluorobenzyne from 2-chloro-6-fluorophenyllithium displays a pronounced solvent-dependent regioselectivity. 6Li and 13C NMR spectroscopic studies on 2-chloro-6-fluorophenyllithium reveal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ddcd80ae858dbdc6888d3f4c7852aac
https://pubmed.ncbi.nlm.nih.gov/15535677
https://pubmed.ncbi.nlm.nih.gov/15535677
Publikováno v:
Organic letters. 6(10)
Noncoordinating solvents permit the halogen−metal exchange-induced formation of benzyne (aryne) from di- and trihalobenzene precursors in the presence of cyclopentadiene to give 1,4-dihydro-1,4-methano-naphthalenes. Studies with mixed halide precur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562fb089a4a7e5975ab629d773e38aa5
https://pubmed.ncbi.nlm.nih.gov/15128243
https://pubmed.ncbi.nlm.nih.gov/15128243
Publikováno v:
Journal of the American Chemical Society. 125(11)
A synthesis of 4,5-benzo-1-aza-tricyclo[4.3.1.1(3,8)]undecane (1), a benzo-1-aza-adamantane derivative, is described and features a previously unknown application of the Wolff-Kishner reduction of a nonresonance stabilized or "twisted" amide. An inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a410928ccba13b09e98ebf8ab95625c0
https://pubmed.ncbi.nlm.nih.gov/12630882
https://pubmed.ncbi.nlm.nih.gov/12630882
Autor:
Kumar Gadamasetti, Tamim Braish
As pharmaceutical companies strive to develop safer medicines at a lower cost, they must keep pace with the rapid growth of technology and research methodologies. Defying the misconception of process chemistry as mere scale-up work, Process Chemistry
