Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Crystal E. Fagan"'
Publikováno v:
bioRxiv
Rapid and accurate translation is essential in all organisms to produce properly folded and functional proteins. mRNA codons that define the protein coding sequences are decoded by tRNAs on the ribosome in the aminoacyl (A) binding site. The mRNA cod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf7ee710891464d3871d6e39cd910b5
https://doi.org/10.1101/2023.01.28.526049
https://doi.org/10.1101/2023.01.28.526049
Autor:
Joshua C. Canzoneri, Christine M. Dunham, Adegboyega K. Oyelere, Tatsuya Maehigashi, Crystal E. Fagan, Sandra C. Mwakwari, Arren Z. Washington, Derek B. Benicewicz
Publikováno v:
ACS Chemical Biology
Despite decades of research on the bacterial ribosome, the ribosomal exit tunnel is still poorly understood. Although it has been suggested that the exit tunnel is simply a convenient route of egress for the nascent chain, specific protein sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10656c6c71c45ceae29e0640c5314e0
https://doi.org/10.1021/cb5003224
https://doi.org/10.1021/cb5003224
Publikováno v:
RNA (New York, N.Y.). 20(12)
The three-nucleotide mRNA reading frame is tightly regulated during translation to ensure accurate protein expression. Translation errors that lead to aberrant protein production can result from the uncoupled movement of the tRNA in either the 5′ o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1513818c5c07ab40dbf9d9fea4555f2
https://pubmed.ncbi.nlm.nih.gov/25352689
https://pubmed.ncbi.nlm.nih.gov/25352689
Autor:
Mai N. Dang, Aishwarya Devaraj, Crystal E. Fagan, Kurt Fredrick, Daoming Qin, Jack A. Dunkle, Stacey J. Miles, Tatsuya Maehigashi, Christine M. Dunham
After four decades of research aimed at understanding tRNA selection on the ribosome, the mechanism by which ribosomal ambiguity ( ram ) mutations promote miscoding remains unclear. Here, we present two X-ray crystal structures of the Thermus thermop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d08c2a53dd0dbf8ace17ec51ba9216e
https://europepmc.org/articles/PMC3683721/
https://europepmc.org/articles/PMC3683721/