Výsledky vyhledávání - "Crystal D. Herdon"

Mechanism of Splenic Immunosuppression During Sepsis

Autor: Irshad H. Chaudry, Alfred Ayala, Crystal D. Herdon, Patrick J. O'Neill, Stacey A. Uebele

Publikováno v: The Journal of Trauma: Injury, Infection, and Critical Care. 42:882-888

Studies indicate that the liver, in particular the Kupffer cells, appear to be key contributors in the systemic inflammatory mediator response associated with shock and sepsis. Although several of these agents have been implicated as mediators of dep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088b3dd59bf709263188c93ae2bc5587
https://doi.org/10.1097/00005373-199705000-00019

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Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators

Autor: Irshad H. Chaudry, Alfred Ayala, Donna L. Lehman, Crystal D. Herdon, Carol A. Ayala

Publikováno v: Blood. 87:4261-4275

Apoptosis (Ao), is a process by which cells undergo a form of nonnecrotic cellular suicide. Although for most cells this is a constitutive process, it can be induced in immature and differentiating immune cell populations by stress mediators associat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6b9d8e7ab40044b1da9e959a5f79ff7
https://doi.org/10.1182/blood.v87.10.4261.bloodjournal87104261

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Polymicrobial Sepsis but Not Low-Dose Endotoxin Infusion Causes Decreased Splenocyte IL-2/IFN-γ Release While Increasing IL-4/IL-10 Production

Autor: Alfred Ayala, Donna L. Lehman, Irshad H. Chaudry, Zoe K. Deol, Crystal D. Herdon

Publikováno v: Journal of Surgical Research. 56:579-585

Although studies indicate that polymicrobial sepsis produces marked depression in lymphocyte functions, it remains unclear whether this dysfunction is due to the chronic exposure of immune cells to endotoxin (ETX; a product of the gram-negative bacte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813ab5fdc6388ba7fc155e558c27ddf6
https://doi.org/10.1006/jsre.1994.1092

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Pentoxifylline Attenuates Oxygen-Induced Lung Injury

Autor: John M. Kisala, Hugh J. Lindsey, Irshad H. Chaudry, Crystal D. Herdon, Donna L. Lehman, Alfred Ayala

Publikováno v: Journal of Surgical Research. 56:543-548

Patients requiring mechanical ventilation can develop severe pulmonary injury. Although pentoxifylline (PTX) is known to attenuate endotoxin and tumor necrosis factor (TNF)-induced lung injury, as well as decrease interleukin-6 (IL-6) levels followin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6945018e16a89e3d753ba15b452407e
https://doi.org/10.1006/jsre.1994.1087

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Is sepsis-induced apoptosis associated with macrophage dysfunction?

Autor: Alfred Ayala, Irshad H. Chaudry, Crystal D. Herdon, Marcy A. Urbanich

Publikováno v: The Journal of trauma. 40(4)

Apoptosis (A O) is a pathological process by which cells undergo a form of inducible nonnecrotic cellular suicide. In vitro studies suggest that changes in the rate of macrophage (Mo) A O may be associated with elevated proinflammatory cytokine secre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e472fc70863bf07fe464e8ae88ef492
https://pubmed.ncbi.nlm.nih.gov/8614034

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Does endotoxin play a major role in inducing the depression of macrophage function during polymicrobial sepsis?

Autor: Irshad H. Chaudry, Crystal D. Herdon, Donna L. Lehman, Zoe K. Deol, Alfred Ayala

Publikováno v: Archives of surgery (Chicago, Ill. : 1960). 130(11)

Endotoxin (ETX) is thought to be the primary inducer of proinflammatory mediator release associated with bacterial sepsis. Furthermore, a number of studies indicate that preexposure of animals to high doses of ETX produces macrophages (M luminal diam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7315c34cd25b48028fc17a66ad5f121
https://pubmed.ncbi.nlm.nih.gov/7487460

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The induction of accelerated thymic programmed cell death during polymicrobial sepsis: control by corticosteroids but not tumor necrosis factor

Autor: Donna L. Lehman, Carol A. Ayala, Crystal D. Herdon, Alfred Ayala, Irshad H. Chaudry, Catherine M. DeMaso

Publikováno v: Shock (Augusta, Ga.). 3(4)

Thymic programmed cell death (PCD) or apoptosis (Ao) is elevated during inflammation by a variety of stressors in vitro (i.e., glucocorticoids, tumor necrosis factor (TNF), prostanoids, etc.), however, little or no information is available concerning

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401e6f836b0dacd7ec6298fb1b397f37
https://pubmed.ncbi.nlm.nih.gov/7600193

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Mechanism of enhanced susceptibility to sepsis following hemorrhage. Interleukin-10 suppression of T-cell response is mediated by eicosanoid-induced interleukin-4 release

Autor: Alfred Ayala, Donna L. Lehman, Crystal D. Herdon, Irshad H. Chaudry

Publikováno v: Archives of surgery (Chicago, Ill. : 1960). 129(11)

Objectives: To determine (1) whether interleukin-10 (IL-10) contributes to depressed T-cell responses observed following hemorrhage and (2) what effect other immunosuppressive agents known to play a role in hemorrhage have on IL-10 release. Design: H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e6b7cd1e6beb29d04cd51970a8b438
https://pubmed.ncbi.nlm.nih.gov/7979949

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