Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Crystal Cabral"'
Autor:
James J. Foti, Kevin Lema, Justin Strickland, Emily Tjon, Adrienne Li, Amalia Rivera, Crystal Cabral, Laura Cormier, Louisa Dowal, Sudhir Rao, Vijetha Vemulapalli, Jessica B. Flechtner
The emergence of SARS-CoV-2 variants are a persistent threat to the efficacy of currently developed prophylactic vaccines and therapeutic antibodies. These variants accumulate mutations in the spike protein which encodes the epitopes necessary for ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6d3064ae262e25b268882b8c920e15c
https://doi.org/10.1101/2022.05.17.491668
https://doi.org/10.1101/2022.05.17.491668
Autor:
Harshal Zope, Rounak Nande, Manish Jain, Charley Hubbard, Louisa Dowal, James Foti, James Loizeaux, Crystal Cabral, Daniel B. DeOliveira, Guohan Yang, Mercay Reuter, Jessica Baker Flechtner, Raymond Stapleton
Publikováno v:
Cancer Research. 82:2745-2745
Background: Neoantigen (neoAg)-specific T cells can be found in the peripheral blood of patients with solid tumors, and the infiltration of fresh, peripherally derived T cells into tumors has been associated with successful outcomes after checkpoint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::865fcc179d57ed25911ae1b5c3c7ca04
https://doi.org/10.1158/1538-7445.am2022-2745
https://doi.org/10.1158/1538-7445.am2022-2745
Autor:
Crystal Cabral, Emily Tjon, Jamie Foti, Alberto Visintin, Madison Milaszewski, Tulin Dadali, Mark M. Awad, James Loizeaux, Vijetha Vemulapalli, Justin Strickland, Louisa Dowal, Jessica Flechtner, Thomas P. Davis, Kesi Michael, Kevin Mancini
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A268-A268
BackgroundEffective immune checkpoint blockade (ICB) treatment is dependent on T-cell recognition of patient-specific mutations (neoantigens). Empirical identification of neoantigens ex vivo has revealed shortcomings of in silico predictions.1 To bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc21fad097082f1c03fee3d4dd33189f
https://doi.org/10.1136/jitc-2021-sitc2021.248
https://doi.org/10.1136/jitc-2021-sitc2021.248
Autor:
Crystal Cabral, Katherine Molloy, Joseph P. Nkolola, Alison L. Hill, David Jetton, Kathryn E. Stephenson, Maria G. Pau, Nelson L. Michael, Hanneke Schuitemaker, Peter Abbink, Lauren Peter, Jinyan Liu, Abishek Chandrashekar, Romas Geleziunas, Jeffrey M. Gerold, Galit Alter, Merlin L. Robb, Jessica Jimenez, Mark G. Lewis, Dan H. Barouch, Benjamin C. Lee, Jerome H. Kim, Joseph Hesselgesser, David Ng’ang’a, Erica N. Borducchi, Shanell Mojta, Amanda L. Brinkman, Jade Mondesir
Publikováno v:
Nature
The development of immunologic interventions that can target the viral reservoir in HIV-1-infected individuals is a major goal of HIV-1 research. However, little evidence exists that the viral reservoir can be sufficiently targeted to improve virolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81dbabb222aace81913686824e21790d
https://doi.org/10.1038/nature20583
https://doi.org/10.1038/nature20583
Autor:
Dan H. Barouch, Crystal Cabral, Jeffrey D. Lifson, Mayuri Shetty, Dennis R. Burton, Rafick-Pierre Sekaly, Abishek Chandrashekar, Wendeline Wagner, Peter Abbink, Lauren Peter, Chantelle Baker, Arnaud D. Colantonio, Jinyan Liu, Amanda L. Brinkman, Jade Mondesir, Yuan Li, Patricia B. Giglio, Erica N. Borducchi, Mark G. Lewis, Brian Berkemeier, Benjamin C. Lee, Elizabeth Chipriano, Khader Ghneim, Courtney Gittens, William J. Bosche, Devin Sok, Wenjun Li, Kelli Oswald, Jessica Jimenez
Publikováno v:
Science. 353:1045-1049
HIV-1–specific broadly neutralizing antibodies (bNAbs) can protect rhesus monkeys against simian-human immunodeficiency virus (SHIV) challenge. However, the site of antibody interception of virus and the mechanism of antibody-mediated protection re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410e2b4e470c5e21d992281a038af391
https://doi.org/10.1126/science.aag0491
https://doi.org/10.1126/science.aag0491
Autor:
James B. Whitney, Joseph Hesselgesser, Stephen Blackmore, Jerome H. Kim, Crystal Cabral, Erica N. Borducchi, Daniel I. S. Rosenbloom, Pablo Penaloza-MacMaster, Lauren Peter, Jennifer L. Shields, Jinyan Liu, Sheeba I. Mathew, Alison L. Hill, Merlin L. Robb, Srisowmya Sanisetty, Bei Li, Amanda L. Brinkman, Jillian Hattersley, Romas Geleziunas, Mayuri Shetty, Mark G. Lewis, Kaitlin M. Smith, Jeffrey Y. Smith, Dan H. Barouch, Lily Parenteau, Nelson L. Michael
Publikováno v:
Nature
The viral reservoir represents a critical challenge for human immunodeficiency virus type 1 (HIV-1) eradication strategies. However, it remains unclear when and where the viral reservoir is seeded during acute infection and the extent to which it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96eacd61efc19756c0a08ffe57ca045c
https://doi.org/10.1038/nature13594
https://doi.org/10.1038/nature13594
Autor:
Melissa Hayes, James Loizeaux, James Perry, Jason R. Dobson, Wendy Broom, Mariya Croll, Anna Lyubetskaya, Crystal Cabral, Christopher L. Warren, James Foti, F. Stephen Hodi, Jessica Flechtner, Louisa Dowal
Publikováno v:
Cancer Research. 79:LB-223
Broadly reinvigorating the T cell response by blocking immune-inhibitory receptors can produce durable clinical benefit in 20-40% of melanoma patients. Due to low response rates and potential toxicity of checkpoint therapy, identification of biomarke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56291d09047aaf03752f9d028a2fae86
https://doi.org/10.1158/1538-7445.am2019-lb-223
https://doi.org/10.1158/1538-7445.am2019-lb-223
Autor:
Thomas P. Monath, Quazim A. Alayo, Christine A. Bricault, Jessica Jimenez, Daniel D. Pinschewer, Dan H. Barouch, Jennifer L. Shields, Bastien Mangeat, Gerhard Fuhrmann, Klaus Orlinger, Pablo Penaloza MacMaster, Abishek Chandrashekar, Anders Lilja, Matthew Lim, Jade Mondesir, M. Justin Iampietro, Nicholas M. Provine, Crystal Cabral, Andreas Aspoeck, Joseph M Cabral, Michael S. Seaman
Publikováno v:
Vaccine. 35(1)
An important focus in vaccine research is the design of vaccine vectors with low seroprevalence and high immunogenicity. Replication-incompetent lymphocytic choriomeningitis virus (rLCMV) vectors do not elicit vector-neutralizing antibody responses,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa332fd93d7758cb40287ce054905ad4
https://pubmed.ncbi.nlm.nih.gov/27899229
https://pubmed.ncbi.nlm.nih.gov/27899229
Autor:
George H. Neubauer, Dan H. Barouch, Michael R. Boyd, Peter Abbink, Rafael De La Barrera, Mark G. Lewis, Jessica Jimenez, Richard G. Jarman, Christine A. Bricault, David Jetton, Noe B. Mercado, Edward T. Moseley, Jean Pierre Schatzmann Peron, Stephen J. Thomas, Nelson L. Michael, Arshi Agarwal, Crystal Cabral, Mayuri Shetty, Amanda L. Brinkman, Galit Alter, Brad Finneyfrock, Marinela Kirilova, Ramya Nityanandam, Shanell Mojta, Erica N. Borducchi, Kayvon Modjarrad, Rafael A. Larocca, Zhenfeng Li, Katherine Molloy, Benjamin C. Lee, Paolo Marinho de Andrade Zanotto, Abishek Chandrashekar, Patricia B. Giglio, Kathryn E. Stephenson, Ovini Nanayakkara, Johnathan Misamore, David Ng’ang’a, Kenneth H. Eckels
Publikováno v:
Science (New York, N.Y.). 353(6304)
Zika virus (ZIKV) is responsible for a major ongoing epidemic in the Americas and has been causally associated with fetal microcephaly. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Here we demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840fa7d939ba133c1b1c84fd4ee8adb4
https://pubmed.ncbi.nlm.nih.gov/27609872
https://pubmed.ncbi.nlm.nih.gov/27609872
Autor:
Michael O'Keeffe, Jason R. Dobson, Christopher L. Warren, James Foti, Ning Wu, Jin Yuan, Huilei Xu, Johanna K. Kaufmann, Jessica Flechtner, Pamela Carroll, Kyle Ferber, Crystal Cabral, Wendy Broom, Erick Donis, James Loizeaux
Publikováno v:
Cancer Research. 78:730-730
Neoantigens arise from tumor-specific, somatic mutations and have the potential to be recognized by T cells that are associated with anti-tumor immune responses. Since they are non-self, they are hypothesized to provide an attractive therapeutic moda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2cc43ea27842f9eb1dbbfd58a7e0f44
https://doi.org/10.1158/1538-7445.am2018-730
https://doi.org/10.1158/1538-7445.am2018-730