Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Crystal A. Tonnessen-Murray"'
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 1 (2020)
The breast tumors that are most difficult to eradicate with chemotherapy have wild-type TP53 and preferentially enter senescence after treatment. One factor contributing to the persistence of senescent cells in residual disease: acquisition of a nove
Externí odkaz:
https://doaj.org/article/23987271eaf94cd48cc0e5ce859fe32e
Autor:
Sonia G. Rao, Crystal A. Tonnessen-Murray, Benjamin T. Vinson, Ashkan Shahbandi, Joy O. Olayiwola, Nathan Ungerleider, James G. Jackson, Douglas B. Chrisey, Christopher J. Lord, Lucas B. Murray, Wesley D. Frey
Publikováno v:
Journal of Cell Biology. 218:3827-3844
In chemotherapy-treated breast cancer, wild-type p53 preferentially induces senescence over apoptosis, resulting in a persisting cell population constituting residual disease that drives relapse and poor patient survival via the senescence-associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec78dd7cafa4d4886d28c30ec784cac
https://doi.org/10.1083/jcb.201904051
https://doi.org/10.1083/jcb.201904051
Autor:
Ethan K. Scott, Samantha J. Stehbens, Jagat Chauhan, Aaron G. Smith, Glen M. Boyle, David S. Hill, Colin R. Goding, Russell J Jurek, Sheena M. Daignault-Mill, Mitchell Fane, Gency Gunasingh, Brian Gabrielli, Nicholas Matigian, Wolfgang Weninger, Kimberley A. Beaumont, Gilles Vanwalleghem, Crystal A Tonnessen-Murray, Loredana Spoerri, Helmut Schaider, Nikolas K. Haass
Phenotypic heterogeneity of cancer cells plays a critical role in shaping treatment response. This type of heterogeneity is organized spatially with specific phenotypes, such as sharply demarcated clusters of proliferating and cell cycle-arrested cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::830ac02b4104d8d31185d81d0ffb827f
https://doi.org/10.1101/2020.06.09.141747
https://doi.org/10.1101/2020.06.09.141747
Autor:
Nathan Ungerleider, Amanda R. Wasylishen, James G. Jackson, Crystal A. Tonnessen-Murray, Sonia G. Rao, Wesley D. Frey
Publikováno v:
Translational Oncology, Vol 11, Iss 4, Pp 930-940 (2018)
Translational Oncology
Translational Oncology
p53 is a transcription factor that regulates expression of genes involved in cell cycle arrest, senescence, and apoptosis. TP53 harbors mutations that inactivate its transcriptional activity in roughly 30% of breast cancers, and these tumors are much
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb629a651bdc557028ef266b4e63582
http://www.sciencedirect.com/science/article/pii/S1936523318301761
http://www.sciencedirect.com/science/article/pii/S1936523318301761
Publikováno v:
Mol Cell Oncol
The breast tumors that are most difficult to eradicate with chemotherapy have wild-type TP53 and preferentially enter senescence after treatment. One factor contributing to the persistence of senescent cells in residual disease: acquisition of a nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0111b9f7652ab522f4be316b206dad5
https://pubmed.ncbi.nlm.nih.gov/31993500
https://pubmed.ncbi.nlm.nih.gov/31993500
Autor:
D. S. Hill, Aaron G. Smith, Jagat Chauhan, Kimberley A. Beaumont, Brian Gabrielli, Colin R. Goding, Helmut Schaider, Nikolas K. Haass, Crystal A Tonnessen-Murray, Loredana Spoerri, Gency Gunasingh, Wolfgang Weninger
Publikováno v:
Journal of Investigative Dermatology. 141:S93
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4bff67817dd1a2b943bf304ead93159
https://doi.org/10.1016/j.jid.2021.02.563
https://doi.org/10.1016/j.jid.2021.02.563
Autor:
Kimberley A. Beaumont, Russell J Jurek, Loredana Spoerri, Nikolas K. Haass, Crystal A Tonnessen-Murray, David S. Hill, Wolfgang Weninger, Gency Gunasingh
Publikováno v:
Journal of Investigative Dermatology. 140:S95
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::663090e6b28a1821ad5107a7714243bd
https://doi.org/10.1016/j.jid.2020.03.719
https://doi.org/10.1016/j.jid.2020.03.719
Transformed cells have properties that allow them to survive and proliferate inappropriately. These characteristics often arise as a result of mutations caused by DNA damage. p53 suppresses transformation by removing the proliferative or survival cap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626b1a0ce78158044d2905b6528a5d9f
https://europepmc.org/articles/PMC5287062/
https://europepmc.org/articles/PMC5287062/