Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Cryptophycin 52"'
Publikováno v:
Journal of Biomolecular Structure and Dynamics
A novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has emerged as the causative agent behind the coronavirus disease 2019 (COVID-19) pandemic. Treatment efforts have been severely impeded due to the lack of specific effective antivira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d237a21d143315f1af07b65f0811069f
https://doi.org/10.1080/07391102.2020.1794972
https://doi.org/10.1080/07391102.2020.1794972
Publikováno v:
The Journal of Biological Chemistry
Cryptophycin-52 (Cp-52) is potentially the most potent anticancer drug known, with IC50 values in the low picomolar range, but its binding site on tubulin and mechanism of action are unknown. Here, we have determined the binding site of Cp-52, and it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea3c09f815f9e1893fb9e6c5c3dc259
https://pubmed.ncbi.nlm.nih.gov/34461087
https://pubmed.ncbi.nlm.nih.gov/34461087
Autor:
Arun K. Ghosh
Publikováno v:
Journal of Medicinal Chemistry. 52:2163-2176
Historically, nature has provided an incredible variety of structurally complex and biologically important molecules. Indeed, a great many of today’s clinical medicines are obtained directly from natural products or from their derivatives.1 Natural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8778393bb4b3db138e874de9eb54c1
https://doi.org/10.1021/jm900064c
https://doi.org/10.1021/jm900064c
Autor:
Richard M. Schultz, Joseph H. Kennedy, Rima S. Al-Awar, Gottumukkala V. Subbaraju, Jian Liang, Thomas H. Corbett, Richard E. Moore, James E. Ray, Sherri L. Andis, Trimurtulu Golakoti
Publikováno v:
Journal of Medicinal Chemistry. 46:2985-3007
Cryptophycin 52 is a synthetic derivative of Cryptophycin 1, a potent antimicrotubule agent isolated from cyanobacteria. In an effort to increase the potency and water solubility of the molecule, a structure-activity relationship study (SAR) was init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea75cbc5fbe1eec811d06b06b062daf
https://doi.org/10.1021/jm0203884
https://doi.org/10.1021/jm0203884
Autor:
Chuan Shih, Beverly A. Teicher
Publikováno v:
Current Pharmaceutical Design. 7:1259-1276
The antitumor cryptophycins are synthetic derivatives of the desipeptide cryptophycins isolated from the cyanobacterium Nostoc sp. Cryptophycin 52 that is currently in clinical trial in solid tumors, is prepared by total synthesis of four key fragmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00821393cafe7828f3aa45f5f5eb9474
https://doi.org/10.2174/1381612013397474
https://doi.org/10.2174/1381612013397474
Publikováno v:
Cancer Chemotherapy and Pharmacology. 47:170-178
Bcl-2 has been described as a factor that can protect from apoptosis. The protective effect of Bcl-2 may be lost if the protein is phosphorylated. Bcl-2 phosphorylation can be induced by agents that affect microtubule depolymerization or prevent micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011c3bc9b75f0490234ff9dbcaad176f
https://doi.org/10.1007/s002800000210
https://doi.org/10.1007/s002800000210
Publikováno v:
Biochemistry. 39:14121-14127
Cryptophycin-52 (LY355703) is currently undergoing clinical evaluation for cancer chemotherapy. It is a potent suppressor of microtubule dynamics in vitro, and low picomolar concentrations appear to inhibit cancer cell proliferation at mitosis by sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bdb195fb9c2c2869234be865ed40de4
https://doi.org/10.1021/bi0010827
https://doi.org/10.1021/bi0010827
Autor:
David Kessel
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 735:121-126
Exposure of murine leukemia L1210 cells to the antitumor antibiotic cryptophycin 52 (C52) resulted in a rapid and dose-dependent increase in cell-surface hydrophobicity, as measured with a two-phase partitioning system. This effect was not observed w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da852cb887910761c67fcba7179b8704
https://doi.org/10.1016/s0378-4347(99)00404-1
https://doi.org/10.1016/s0378-4347(99)00404-1
Autor:
Erwin von Angerer
Publikováno v:
Expert Opinion on Therapeutic Patents. 9:1069-1081
Despite the relatively long tradition of the vinca alkaloids in cancer chemotherapy, the spectrum of compounds with the same mode of action has until recently been quite small. It was mainly the discovery of paclitaxel (Taxol®, Bristol-Myers Squibb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a55e3c85a56e17f50a7039a59b550646
https://doi.org/10.1517/13543776.9.8.1069
https://doi.org/10.1517/13543776.9.8.1069
Autor:
Russell A. Barrow, Seunguk Paik, Richard E. Moore, Marcus A. Tius, Thomas Hemscheidt, Liang Jian
Publikováno v:
Journal of the American Chemical Society. 117:2479-2490
The convergent total synthesis of cryptophycins C and D is described. It has been shown that in both natural products the absolute configuration of the a-amino acid corresponds to the D-series. The structural assignment for cryptophycin C has been co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edcb2b5ca1d1b8aa94212a190e5a789e
https://doi.org/10.1021/ja00114a011
https://doi.org/10.1021/ja00114a011