Cyclic natural product oligomers: diversity and (bio)synthesis of macrocycles.

Autor: Zhang S; CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.; Shenzhen Key Laboratory of Genome Manipulation and Biosynthesis, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China., Fan S; NHC Key Laboratory of Biotechnology for Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China., He H; CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.; Shenzhen Key Laboratory of Genome Manipulation and Biosynthesis, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China., Zhu J; CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.; Shenzhen Key Laboratory of Genome Manipulation and Biosynthesis, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China., Murray L; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, 3800, Australia.; EMBL Australia, Monash University, Clayton, Victoria, 3800, Australia.; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Monash University, Clayton, Victoria, 3800, Australia., Liang G; CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.; Shenzhen Key Laboratory of Genome Manipulation and Biosynthesis, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China., Ran S; NHC Key Laboratory of Biotechnology for Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China., Zhu YZ; School of Pharmacy & State Key Lab. for the Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China., Cryle MJ; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, 3800, Australia.; EMBL Australia, Monash University, Clayton, Victoria, 3800, Australia.; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Monash University, Clayton, Victoria, 3800, Australia., He HY; NHC Key Laboratory of Biotechnology for Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China., Zhang Y; CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.; Helmholtz International Lab for Anti-infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China. zhangyouming@sdu.edu.cn.; Shenzhen Key Laboratory of Genome Manipulation and Biosynthesis, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Publikováno v: Chemical Society reviews [Chem Soc Rev] 2024 Nov 25. Date of Electronic Publication: 2024 Nov 25.

Advancing Nitrile-Aminothiol Strategy for Dual and Sequential Bioconjugation.

Autor: Thombare VJ; Department of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, 3800, Australia., Wu Y; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, 3800, Australia., Pamulapati K; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, 3800, Australia., Han M; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, 3800, Australia., Tailhades J; Department of Biochemistry Biomedicine Discovery Institute, Monash University, Clayton, Victoria, 3800, Australia.; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Australia., Cryle MJ; Department of Biochemistry Biomedicine Discovery Institute, Monash University, Clayton, Victoria, 3800, Australia.; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Australia., Roberts KD; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, 3800, Australia., Velkov T; Department of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, 3800, Australia., Li J; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, 3800, Australia., Patil NA; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, 3800, Australia.; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Australia.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Aug 19; Vol. 30 (46), pp. e202401674. Date of Electronic Publication: 2024 Jul 25.

Enzyme engineering lets us play with new building blocks in non-ribosomal peptide synthesis.

Autor: Ratnayake MS; The Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; EMBL Australia, Monash University, Clayton, VIC 3800, Australia; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Clayton, VIC 3800, Australia., Hansen MH; The Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; EMBL Australia, Monash University, Clayton, VIC 3800, Australia; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Clayton, VIC 3800, Australia., Cryle MJ; The Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; EMBL Australia, Monash University, Clayton, VIC 3800, Australia; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Clayton, VIC 3800, Australia. Electronic address: max.cryle@monash.edu.

Publikováno v: Structure (London, England : 1993) [Structure] 2024 May 02; Vol. 32 (5), pp. 520-522.

An Engineered Biarylitide Cross-Linking P450 from RiPP Biosynthesis Generates Alternative Cyclic Peptides.

Autor: Treisman M; Department of Biochemistry and Molecular Biology, The Monash Biomedicine Discovery Institute, Monash University, EMBL Australia, Clayton, VIC 3800, Australia.; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Clayton, VIC 3800, Australia., Coe L; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia., Zhao Y; Department of Biochemistry and Molecular Biology, The Monash Biomedicine Discovery Institute, Monash University, EMBL Australia, Clayton, VIC 3800, Australia.; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Clayton, VIC 3800, Australia., Sasi VM; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Clayton, VIC 3800, Australia.; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.; Research School of Chemistry, The Australian National University, Acton, ACT 2601, Australia., Gullick J; Department of Biochemistry and Molecular Biology, The Monash Biomedicine Discovery Institute, Monash University, EMBL Australia, Clayton, VIC 3800, Australia.; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Clayton, VIC 3800, Australia., Hansen MH; Department of Biochemistry and Molecular Biology, The Monash Biomedicine Discovery Institute, Monash University, EMBL Australia, Clayton, VIC 3800, Australia.; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Clayton, VIC 3800, Australia., Ly A; Department of Chemistry, Monash University, Clayton, VIC 3800, Australia., Leichthammer V; Department of Biochemistry and Molecular Biology, The Monash Biomedicine Discovery Institute, Monash University, EMBL Australia, Clayton, VIC 3800, Australia.; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Clayton, VIC 3800, Australia., Hess C; Department of Biochemistry and Molecular Biology, The Monash Biomedicine Discovery Institute, Monash University, EMBL Australia, Clayton, VIC 3800, Australia.; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Clayton, VIC 3800, Australia., Machell DL; Department of Biochemistry and Molecular Biology, The Monash Biomedicine Discovery Institute, Monash University, EMBL Australia, Clayton, VIC 3800, Australia.; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Clayton, VIC 3800, Australia., Schittenhelm RB; Monash Proteomics and Metabolomics Platform, Monash University, Clayton, VIC 3800, Australia., Hooper J; Department of Chemistry, Monash University, Clayton, VIC 3800, Australia., Jackson CJ; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Clayton, VIC 3800, Australia.; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.; Research School of Chemistry, The Australian National University, Acton, ACT 2601, Australia.; ARC Centre of Excellence in Synthetic Biology, Australian National University, Acton, ACT 2601, Australia.; Research School of Biology, Australian National University, Acton, ACT 2601, Australia., Tailhades J; Department of Biochemistry and Molecular Biology, The Monash Biomedicine Discovery Institute, Monash University, EMBL Australia, Clayton, VIC 3800, Australia.; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Clayton, VIC 3800, Australia., De Voss JJ; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia., Cryle MJ; Department of Biochemistry and Molecular Biology, The Monash Biomedicine Discovery Institute, Monash University, EMBL Australia, Clayton, VIC 3800, Australia.; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Clayton, VIC 3800, Australia.

Publikováno v: Organic letters [Org Lett] 2024 Mar 08; Vol. 26 (9), pp. 1828-1833. Date of Electronic Publication: 2024 Feb 28.

An in vitro assay to explore condensation domain specificity from non-ribosomal peptide synthesis.

Autor: Ratnayake M; Department of Biochemistry and Molecular Biology, The Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia; EMBL Australia, Monash University, Clayton, VIC, Australia; ARC Centre of Excellence for Innovations in Peptide and Protein Science., Ho YTC; Department of Chemistry, University of Warwick, Coventry, United Kingdom., Jian X; Department of Biochemistry and Molecular Biology, The Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia; EMBL Australia, Monash University, Clayton, VIC, Australia; ARC Centre of Excellence for Innovations in Peptide and Protein Science., Cryle MJ; Department of Biochemistry and Molecular Biology, The Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia; EMBL Australia, Monash University, Clayton, VIC, Australia; ARC Centre of Excellence for Innovations in Peptide and Protein Science. Electronic address: max.cryle@monash.edu.

Publikováno v: Methods in enzymology [Methods Enzymol] 2024; Vol. 702, pp. 89-119. Date of Electronic Publication: 2024 Jul 20.