Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2.

Autor: Lv D; UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Dixit D; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA., Cruz AF; Brain Tumor Biology and Therapy Lab, Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA., Kim LJY; Division of Regenerative Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92037, USA; Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Duan L; Department of Pharmacology and Cancer Biology, Duke Cancer Institute, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27710, USA., Xu X; Princess Margaret Cancer Centre/University Health Network, Toronto, ON, Canada., Wu Q; UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Zhong C; UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Lu C; School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, Jiangsu, China., Gersey ZC; Brain Tumor Biology and Therapy Lab, Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA., Gimple RC; Division of Regenerative Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92037, USA; Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Xie Q; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Westlake University, Hangzhou 310024, Zhejiang, China., Yang K; Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA., Liu X; Department of Molecular and Structural Chemistry, North Carolina State University, Raleigh, NC 27695, USA., Fang X; Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA., Wu X; UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Kidwell RL; Division of Regenerative Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92037, USA., Wang X; School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, Jiangsu, China., Bao S; Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA., He HH; Princess Margaret Cancer Centre/University Health Network, Toronto, ON, Canada., Locasale JW; Department of Pharmacology and Cancer Biology, Duke Cancer Institute, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27710, USA., Agnihotri S; Brain Tumor Biology and Therapy Lab, Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. Electronic address: sameer.agnihotri@gmail.com., Rich JN; UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Division of Regenerative Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92037, USA; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: drjeremyrich@gmail.com.

Publikováno v: Cell metabolism [Cell Metab] 2024 Nov 05; Vol. 36 (11), pp. 2419-2436.e8. Date of Electronic Publication: 2024 Oct 24.

Problematic Proteins: A Patient with a High Paraprotein Concentration.

Autor: Hortin GL; Department of Pathology, Moffitt Cancer Center, Tampa, FL, United States.; Department of Oncologic Science, Morsani College of Medicine, University of South Florida, Tampa, FL, United States., Stapp RT; Department of Pathology, Moffitt Cancer Center, Tampa, FL, United States.; Department of Oncologic Science, Morsani College of Medicine, University of South Florida, Tampa, FL, United States., Thapa SB; Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL, United States., Grajales-Cruz AF; Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL, United States.

Publikováno v: Clinical chemistry [Clin Chem] 2024 Jul 05; Vol. 70 (7), pp. 905-908.

Molecular mechanism of cellulose depolymerization by the two-domain BlCel9A enzyme from the glycoside hydrolase family 9.

Autor: de Araújo EA; Brazilian Synchrotron Light Laboratory, Brazilian Center for Research in Energy and Materials, Giuseppe Maximo Scolfaro, 10000, Campinas, SP 13083-970, Brazil; Sao Carlos Institute of Physics, University of Sao Paulo, Av. Trabalhador Sao Carlense, 400, Sao Carlos, SP 13566-590, Brazil., Cortez AA; Sao Carlos Institute of Physics, University of Sao Paulo, Av. Trabalhador Sao Carlense, 400, Sao Carlos, SP 13566-590, Brazil., Pellegrini VOA; Sao Carlos Institute of Physics, University of Sao Paulo, Av. Trabalhador Sao Carlense, 400, Sao Carlos, SP 13566-590, Brazil., Vacilotto MM; Sao Carlos Institute of Physics, University of Sao Paulo, Av. Trabalhador Sao Carlense, 400, Sao Carlos, SP 13566-590, Brazil., Cruz AF; Sao Carlos Institute of Physics, University of Sao Paulo, Av. Trabalhador Sao Carlense, 400, Sao Carlos, SP 13566-590, Brazil., Batista PR; Oswaldo Cruz Foundation, Scientific Computing Programme, Av. Brasil, 4365, Rio de Janeiro, RJ 21040-900, Brazil., Polikarpov I; Sao Carlos Institute of Physics, University of Sao Paulo, Av. Trabalhador Sao Carlense, 400, Sao Carlos, SP 13566-590, Brazil. Electronic address: ipolikarpov@ifsc.usp.br.

Publikováno v: Carbohydrate polymers [Carbohydr Polym] 2024 Apr 01; Vol. 329, pp. 121739. Date of Electronic Publication: 2024 Jan 08.

An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma.

Autor: Casillo SM; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Gatesman TA; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Chilukuri A; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Varadharajan S; Department of Pediatric Hematology and Oncology, St Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Johnson BJ; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., David Premkumar DR; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Jane EP; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Plute TJ; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Koncar RF; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Stanton AJ; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Biagi-Junior CAO; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Barber CS; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Halbert ME; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Golbourn BJ; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Halligan K; Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pittsburgh, PA 15261, USA; Division of Hematology Oncology, Department of Pediatrics, Albany Medical College, Albany, NY 12208, USA., Cruz AF; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Mansi NM; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Cheney A; Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; University of California, Santa Cruz Genomics Institute, Santa Cruz, CA 95064, USA., Mullett SJ; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Land CV; Division of Genetic and Genomic Medicine, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15261, USA; Rangos Metabolic Core Facility, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15224, USA., Perez JL; Department of Neurological Surgery, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA., Myers MI; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Agrawal N; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Michel JJ; Rangos Flow Cytometry Core Laboratory, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15224, USA., Chang YF; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Vaske OM; Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; University of California, Santa Cruz Genomics Institute, Santa Cruz, CA 95064, USA., MichaelRaj A; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Lieberman FS; Adult Neuro-Oncology Program, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA., Felker J; Pediatric Neuro-Oncology Program, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA., Shiva S; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Heart, Lung, Blood, and Vascular Medicine Institute, Department of Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Bertrand KC; Department of Pediatric Hematology and Oncology, St Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Amankulor N; Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA., Hadjipanayis CG; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Abdullah KG; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Zinn PO; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Friedlander RM; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Abel TJ; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Nazarian J; Brain Tumor Institute, Children's National Hospital, Washington, DC 20010, USA., Venneti S; Laboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA., Filbin MG; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Gelhaus SL; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA 15224, USA., Mack SC; Department of Pediatric Hematology and Oncology, St Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Pollack IF; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Agnihotri S; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Pediatric Neuro-Oncology Program, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA. Electronic address: sameer.agnihotri@pitt.edu.

Publikováno v: Cell reports [Cell Rep] 2024 Jan 23; Vol. 43 (1), pp. 113557. Date of Electronic Publication: 2023 Dec 18.

Sustained vs. Intratidal Recruitment in the Injured Lung During Airway Pressure Release Ventilation: A Computational Modeling Perspective.

Autor: Cruz AF; Department of Anesthesia, University of Iowa, Iowa City, IA 52242, USA., Herrmann J; Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA., Ramcharran H; Department of Surgery, SUNY Upstate Medical Center, Syracuse, NY 13210, USA., Kollisch-Singule M; Department of Surgery, SUNY Upstate Medical Center, Syracuse, NY 13210, USA., Tawhai MH; Department of Bioengineering, University of Auckland, Auckland 1124, New Zealand., Bates JHT; Department of Medicine, University of Vermont, Burlington, VT 05405, USA., Nieman GF; Department of Surgery, SUNY Upstate Medical Center, Syracuse, NY 13210, USA., Kaczka DW; Department of Anesthesia, University of Iowa, Iowa City, IA 52242, USA.; Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA.; Department of Radiology, University of Iowa, Iowa City, IA 52242, USA.

Publikováno v: Military medicine [Mil Med] 2023 Nov 08; Vol. 188 (Suppl 6), pp. 141-148.