Complementary dual-virus strategy drives synthetic target and cognate T-cell engager expression for endogenous-antigen agnostic immunotherapy.

Autor: Taha Z; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada. ztaha053@uottawa.ca.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. ztaha053@uottawa.ca., Crupi MJF; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada. mcrupi@ohri.ca.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. mcrupi@ohri.ca., Alluqmani N; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., MacKenzie D; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Vallati S; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Whelan JT; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Fareez F; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada., Alwithenani A; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Petryk J; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Chen A; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Spinelli MM; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Ng K; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Sobh J; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., de Souza CT; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Bharadwa PR; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Lee TKH; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Thomas DA; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Huang BZ; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Kassas O; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Poutou J; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Gilchrist VH; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Boulton S; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Thomson M; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Marius R; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Hooshyar M; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., McComb S; Cancer Immunology Team, National Research Council of Canada, Human Health Therapeutics, Ottawa, ON, K1A 0R6, Canada., Arulanandam R; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Ilkow CS; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Bell JC; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada. jbell@ohri.ca.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. jbell@ohri.ca., Diallo JS; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada. jsdiallo@ohri.ca.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. jsdiallo@ohri.ca.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 23; Vol. 15 (1), pp. 7267. Date of Electronic Publication: 2024 Aug 23.

Loss of Tumour Suppressor TMEM127 Drives RET-mediated Transformation Through Disrupted Membrane Dynamics.

Autor: Walker TJ; Division of Cancer Biology and Genetics, Cancer Research Institute, and Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, K7L 3N6, Canada., Reyes-Alvarez E; Division of Cancer Biology and Genetics, Cancer Research Institute, and Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, K7L 3N6, Canada., Hyndman BD; Division of Cancer Biology and Genetics, Cancer Research Institute, and Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, K7L 3N6, Canada., Sugiyama MG; Department of Chemistry and Biology, Toronto Metropolitan University, Toronto, ON, M5B 2K3, Canada., Oliveira LCB; Division of Cancer Biology and Genetics, Cancer Research Institute, and Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, K7L 3N6, Canada., Rekab AN; Division of Cancer Biology and Genetics, Cancer Research Institute, and Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, K7L 3N6, Canada., Crupi MJF; Division of Cancer Biology and Genetics, Cancer Research Institute, and Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, K7L 3N6, Canada., Cabral-Dias R; Department of Chemistry and Biology, Toronto Metropolitan University, Toronto, ON, M5B 2K3, Canada., Guo Q; Division of Hematology and Medical Oncology, University of Texas Health Science Center, San Antonio, Texas, 78229, United States., Dahia PLM; Division of Hematology and Medical Oncology, University of Texas Health Science Center, San Antonio, Texas, 78229, United States., Richardson DS; Department of Molecular and Cellular Biology; Harvard Center for Biological Imaging; Scientific Image Analysis Group, Harvard University, Cambridge, MA, USA., Antonescu CN; Department of Chemistry and Biology, Toronto Metropolitan University, Toronto, ON, M5B 2K3, Canada., Mulligan LM; Division of Cancer Biology and Genetics, Cancer Research Institute, and Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, K7L 3N6, Canada.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 03. Date of Electronic Publication: 2024 Apr 03.

A T cell-targeted multi-antigen vaccine generates robust cellular and humoral immunity against SARS-CoV-2 infection.

Autor: Boulton S; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Poutou J; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Gill R; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Alluqmani N; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., He X; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Singaravelu R; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Crupi MJF; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Petryk J; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Austin B; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Angka L; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Taha Z; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Teo I; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Singh S; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Jamil R; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Marius R; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Martin N; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Jamieson T; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Azad T; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Faculty of Medicine and Health Sciences, Department of Microbiology and Infectious Diseases, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada.; Centre de Recherche du CHUS, Sherbrooke, QC J1H 5N4, Canada., Diallo JS; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Ilkow CS; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Bell JC; Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2023 Sep 16; Vol. 31, pp. 101110. Date of Electronic Publication: 2023 Sep 16 (Print Publication: 2023).

Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies.

Autor: Azad T; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Faculty of Medicine and Health Sciences, Department of Microbiology and Infectious Diseases, Université de Sherbrooke, Sherbrooke, QC, J1E 4K8, Canada.; Centre de Recherche du CHUS, Sherbrooke, QC, J1H 5N4, Canada., Rezaei R; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Singaravelu R; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Pelin A; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, CA 94158, USA., Boulton S; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Petryk J; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Onsu KA; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Martin NT; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Hoskin V; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Ghahremani M; Department of Biology, University of Ottawa, Ottawa, ON, K1N 6N5, Canada., Marotel M; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.; Center for Infection, Immunity, and Inflammation, University of Ottawa, Ottawa, ON, K1H, Canada., Marius R; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., He X; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Crupi MJF; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Hoang HD; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, K1H 8L1, Canada., Nik-Akhtar A; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.; Department of Biology, Ottawa Institute of Systems Biology, Carleton University, Ottawa, ON, K1S 5B6, Canada., Ahmadi M; Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran., Zamani NK; Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran., Golshani A; Department of Biology, Ottawa Institute of Systems Biology, Carleton University, Ottawa, ON, K1S 5B6, Canada., Alain T; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, K1H 8L1, Canada., Greer P; Department of Pathology and Molecular Medicine, Queens University, Kingston, ON, K7L 3N6, Canada., Ardolino M; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.; Center for Infection, Immunity, and Inflammation, University of Ottawa, Ottawa, ON, K1H, Canada., Dickinson BC; Department of Chemistry, The University of Chicago, Chicago, IL, USA., Tai LH; Centre de Recherche du CHUS, Sherbrooke, QC, J1H 5N4, Canada.; Department of Immunology & Cell Biology, Université de Sherbrooke, Sherbrooke, QC, J1E 4K8, Canada., Ilkow CS; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Bell JC; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada. jbell@ohri.ca.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. jbell@ohri.ca.

Publikováno v: Nature communications [Nat Commun] 2023 May 26; Vol. 14 (1), pp. 3035. Date of Electronic Publication: 2023 May 26.

Syngeneic mouse model of human HER2+ metastatic breast cancer for the evaluation of trastuzumab emtansine combined with oncolytic rhabdovirus.

Autor: Taha Z; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Crupi MJF; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Alluqmani N; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Fareez F; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada., Ng K; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Sobh J; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Lee E; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Chen A; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Thomson M; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Spinelli MM; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Ilkow CS; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Bell JC; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Arulanandam R; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Diallo JS; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Apr 19; Vol. 14, pp. 1181014. Date of Electronic Publication: 2023 Apr 19 (Print Publication: 2023).