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An overview of the efficacy and safety of brexpiprazole for the treatment of schizophrenia in adolescents.

Autor: Crump CJ; Mood Disorders Research Program, Depression Center, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY, USA., Abuelazm H; Mood Disorders Research Program, Depression Center, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY, USA., Ibrahim K; Mood Disorders Research Program, Depression Center, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY, USA., Shah S; Mood Disorders Research Program, Depression Center, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY, USA., El-Mallakh RS; Mood Disorders Research Program, Depression Center, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY, USA.

Publikováno v: Expert review of neurotherapeutics [Expert Rev Neurother] 2024 Aug; Vol. 24 (8), pp. 727-733. Date of Electronic Publication: 2024 Jul 05.

Pimavanserin for bipolar disorder.

Autor: Crump CJ; Mood Disorders Research Program, Depression Center, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA., Litteral CA; Mood Disorders Research Program, Depression Center, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA., Elsayed OH; Mood Disorders Research Program, Depression Center, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA., El-Mallakh RS; Mood Disorders Research Program, Depression Center, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA.

Publikováno v: Bipolar disorders [Bipolar Disord] 2022 Sep; Vol. 24 (6), pp. 697-699. Date of Electronic Publication: 2022 Feb 24.

Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular γ-Secretase.

Autor: Crump CJ; Chemical Biology Program, Memorial Sloan Kettering Cancer Center , 1275 York Avenue, New York, New York 10065, United States., Murrey HE; Pfizer Worldwide Research and Development , Worldwide Medicinal Chemistry, Cambridge, Massachusetts 02139, United States., Ballard TE; Pfizer Worldwide Research and Development , Worldwide Medicinal Chemistry Groton, Connecticut 06340, United States., Am Ende CW; Pfizer Worldwide Research and Development , Worldwide Medicinal Chemistry Groton, Connecticut 06340, United States., Wu X; Chemical Biology Program, Memorial Sloan Kettering Cancer Center , 1275 York Avenue, New York, New York 10065, United States., Gertsik N; Chemical Biology Program, Memorial Sloan Kettering Cancer Center , 1275 York Avenue, New York, New York 10065, United States., Johnson DS; Pfizer Worldwide Research and Development , Worldwide Medicinal Chemistry, Cambridge, Massachusetts 02139, United States., Li YM; Chemical Biology Program, Memorial Sloan Kettering Cancer Center , 1275 York Avenue, New York, New York 10065, United States.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2016 Aug 17; Vol. 7 (8), pp. 1166-73. Date of Electronic Publication: 2016 Jun 17.

γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin.

Autor: Pozdnyakov N; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139., Murrey HE; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139., Crump CJ; Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065; Department of Pharmacology, Weill Graduate School of Medical Science of Cornell University, New York, New York 10021., Pettersson M; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139., Ballard TE; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139., Am Ende CW; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139., Ahn K; Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065; Department of Pharmacology, Weill Graduate School of Medical Science of Cornell University, New York, New York 10021., Li YM; Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065; Department of Pharmacology, Weill Graduate School of Medical Science of Cornell University, New York, New York 10021., Bales KR; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139. Electronic address: kelly.bales@pfizer.com., Johnson DS; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139. Electronic address: doug.johnson@pfizer.com.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2013 Apr 05; Vol. 288 (14), pp. 9710-9720. Date of Electronic Publication: 2013 Feb 08.