IFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation

Autor: Vuillier, Françoise, Li, Zhi, Black, Iain, Cruciani, Melania, Rubino, Erminia, Michel, Frédérique, Pellegrini, Sandra

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, 2022, 13, pp.939907. ⟨10.3389/fimmu.2022.939907⟩

Regulation of innate immune responses is essential for maintenance of immune homeostasis and development of an appropriate immunity against microbial infection. We show here that miR-3614-5p, product of the TRIM25 host gene, is induced by type I inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0abe50b08ef6dbf7939da507bfdfba

Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3'Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21

Autor: Rubino, Erminia, Cruciani, Melania, Tchitchek, Nicolas, Le Tortorec, Anna, ROLLAND, Antoine, Veli, Önay, Vallet, Leslie, Gaggi, Giulia, Michel, Frédérique, Dejucq-Rainsford, Nathalie, Pellegrini, Sandra

Publikováno v: Frontiers in Genetics
Frontiers in Genetics, Frontiers, 2021, 11, ⟨10.3389/fgene.2020.627007⟩
Frontiers in Genetics, 2021, 11, ⟨10.3389/fgene.2020.627007⟩

International audience; Ubiquitin-specific peptidase 18 (USP18) acts as gatekeeper of type I interferon (IFN) responses by binding to the IFN receptor subunit IFNAR2 and preventing activation of the downstream JAK/STAT pathway. In any given cell type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3c1574872057b39c73133177729bfe8c
https://hal.sorbonne-universite.fr/hal-03154598/document

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Genome-Wide Gene Expression Analysis of Mtb-Infected DC Highlights the Rapamycin-Driven Modulation of Regulatory Cytokines via the mTOR/GSK-3β Axis.

Autor: Etna, Marilena P., Severa, Martina, Licursi, Valerio, Pardini, Manuela, Cruciani, Melania, Rizzo, Fabiana, Giacomini, Elena, Macchia, Gianfranco, Palumbo, Orazio, Stallone, Raffaella, Carella, Massimo, Livingstone, Mark, Negri, Rodolfo, Pellegrini, Sandra, Coccia, Eliana M.

Publikováno v: Frontiers in Immunology; 4/16/2021, Vol. 11, pN.PAG-N.PAG, 16p

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