C5 methylation confers accessibility, stability and selectivity to picrotoxinin.

Autor: Tong G; Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California, 92037, USA., Griffin S; Corteva Agriscience, 9330 Zionsville Road, Indianapolis, Indiana, 46268, USA., Sader A; Corteva Agriscience, 9330 Zionsville Road, Indianapolis, Indiana, 46268, USA., Crowell AB; Department of Chemistry and Biochemistry, Oberlin College, 119 Woodland Street, Oberlin, Ohio, 44074, USA., Beavers K; Corteva Agriscience, 9330 Zionsville Road, Indianapolis, Indiana, 46268, USA., Watson J; Corteva Agriscience, 9330 Zionsville Road, Indianapolis, Indiana, 46268, USA., Buchan Z; Corteva Agriscience, 9330 Zionsville Road, Indianapolis, Indiana, 46268, USA., Chen S; Department of Chemistry and Biochemistry, Oberlin College, 119 Woodland Street, Oberlin, Ohio, 44074, USA. shuming.chen@oberlin.edu., Shenvi RA; Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California, 92037, USA. rshenvi@scripps.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Dec 14; Vol. 14 (1), pp. 8308. Date of Electronic Publication: 2023 Dec 14.