Steering research on mRNA splicing in cancer towards clinical translation.

Autor: Anczukow O; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. olga.anczukow@jax.org., Allain FH; Department of Biology, Eidgenössische Technische Hochschule (ETH), Zürich, Switzerland., Angarola BL; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Black DL; Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, USA., Brooks AN; Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA, USA., Cheng C; Department of Molecular and Human Genetics, Lester & Sue Breast Center, Baylor College of Medicine, Houston, TX, USA., Conesa A; Institute for Integrative Systems Biology, Spanish National Research Council, Paterna, Spain., Crosse EI; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Eyras E; Shine-Dalgarno Centre for RNA Innovation, Australian National University, Canberra, Australian Capital Territory, Australia., Guccione E; Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY, USA., Lu SX; Department of Medicine, Stanford Medical School, Palo Alto, CA, USA., Neugebauer KM; Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT, USA., Sehgal P; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Song X; Department of Neurology, Northwestern University, Chicago, IL, USA., Tothova Z; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Valcárcel J; Centre for Genomic Regulation, Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain., Weeks KM; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA., Yeo GW; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Thomas-Tikhonenko A; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. andreit@pennmedicine.upenn.edu.; Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. andreit@pennmedicine.upenn.edu.

Publikováno v: Nature reviews. Cancer [Nat Rev Cancer] 2024 Dec; Vol. 24 (12), pp. 887-905. Date of Electronic Publication: 2024 Oct 09.

Multiplexed screening reveals how cancer-specific alternative polyadenylation shapes tumor growth in vivo.

Autor: Gabel AM; Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Medical Scientist Training Program, University of Washington, Seattle, WA, USA., Belleville AE; Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Medical Scientist Training Program, University of Washington, Seattle, WA, USA.; Molecular and Cellular Biology Program, University of Washington, Seattle, WA, USA., Thomas JD; Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., McKellar SA; Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Medical Scientist Training Program, University of Washington, Seattle, WA, USA.; Molecular and Cellular Biology Program, University of Washington, Seattle, WA, USA., Nicholas TR; Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Banjo T; Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Crosse EI; Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Bradley RK; Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. rbradley@fredhutch.org.; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. rbradley@fredhutch.org.; Department of Genome Sciences, University of Washington, Seattle, WA, USA. rbradley@fredhutch.org.

Publikováno v: Nature communications [Nat Commun] 2024 Feb 01; Vol. 15 (1), pp. 959. Date of Electronic Publication: 2024 Feb 01.

Limb development genes underlie variation in human fingerprint patterns.

Autor: Li J; State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai 200438, PRC; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, PRC., Glover JD; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Zhang H; Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200438, PRC., Peng M; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, PRC; Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200438, PRC., Tan J; Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200438, PRC., Mallick CB; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK; Centre for Genetic Disorders, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India., Hou D; Chinese Academy of Sciences Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, PRC., Yang Y; Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200438, PRC., Wu S; State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai 200438, PRC; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, PRC., Liu Y; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, PRC., Peng Q; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, PRC., Zheng SC; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, PRC., Crosse EI; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK., Medvinsky A; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK., Anderson RA; MRC Centre for Reproductive Health, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK., Brown H; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Yuan Z; Fudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu 225326, PRC., Zhou S; Shanghai Foreign Language School, Shanghai 200083, PRC., Xu Y; Forest Ridge School of the Sacred Heart, Bellevue, WA 98006, USA., Kemp JP; University of Queensland Diamantina Institute, University of Queensland, Brisbane, QLD, Australia., Ho YYW; QIMR Berghofer Medical Rese Institute, Brisbane, QLD, Australia., Loesch DZ; Psychology Department, La Trobe University, Melbourne, VIC, Australia., Wang L; WeGene, Shenzhen, Guangdong 518040, PRC., Li Y; WeGene, Shenzhen, Guangdong 518040, PRC., Tang S; WeGene, Shenzhen, Guangdong 518040, PRC., Wu X; WeGene, Shenzhen, Guangdong 518040, PRC., Walters RG; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; Medical Research Council Population Health Research Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Lin K; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Meng R; Center for Data Science in Health and Medicine, Peking University, Beijing 100191, PRC., Lv J; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, PRC., Chernus JM; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA., Neiswanger K; Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, University of Pittsburgh, Pittsburgh, PA 15219, USA., Feingold E; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA., Evans DM; University of Queensland Diamantina Institute, University of Queensland, Brisbane, QLD, Australia; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Medland SE; QIMR Berghofer Medical Rese Institute, Brisbane, QLD, Australia., Martin NG; QIMR Berghofer Medical Rese Institute, Brisbane, QLD, Australia., Weinberg SM; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA; Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Anthropology, University of Pittsburgh, Pittsburgh, PA 15260, USA., Marazita ML; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA; Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, University of Pittsburgh, Pittsburgh, PA 15219, USA; Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15261, USA., Chen G; WeGene, Shenzhen, Guangdong 518040, PRC., Chen Z; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; Medical Research Council Population Health Research Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Zhou Y; Clinical Research Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PRC., Cheeseman M; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Wang L; Chinese Academy of Sciences Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, PRC., Jin L; State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai 200438, PRC; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, PRC; Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019RU058), Chinese Academy of Medical Sciences, Shanghai 200438, PRC. Electronic address: lijin@fudan.edu.cn., Headon DJ; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK. Electronic address: denis.headon@roslin.ed.ac.uk., Wang S; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, PRC; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, PRC. Electronic address: wangsijia@picb.ac.cn.

Publikováno v: Cell [Cell] 2022 Jan 06; Vol. 185 (1), pp. 95-112.e18.