Discovery of a Novel, Potent, and Specific Family of Factor Xa Inhibitors via Combinatorial Chemistry

Autor: Wildgoose P, James A. Ostrem, D. Thorpe, Lebl M, Fahad Al-Obeidi, Spoonamore J, Cross Mt, Safarova A, Stringer Sk, Patek M, Pavel Safar, Sepetov N, Strop P, Kasireddy P, LoCascio Jc

Publikováno v: Biochemistry. 37:1053-1059

A series of low molecular weight peptide inhibitors of factor Xa, unrelated to any previously described, was identified by screening a combinatorial peptide library composed of L-amino acids. The minimal inhibitory sequence is a tripeptide, L-tyrosin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bc105f3357b05aef29dacca118fe77
https://doi.org/10.1021/bi971147e

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Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease.

Autor: Singanayagam A; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom., Footitt J; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Marczynski M; School of Engineering and Design, Department of Materials Engineering and.; Center for Protein Assemblies, Technical University of Munich, Munich, Germany., Radicioni G; Marsico Lung Institute/Cystic Fibrosis and Pulmonary Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Cross MT; Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA., Finney LJ; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Trujillo-Torralbo MB; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Calderazzo M; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Zhu J; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Aniscenko J; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Clarke TB; Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom., Molyneaux PL; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Bartlett NW; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; College of Health, Medicine and Wellbeing, Hunter Medical Research Institute and University of Newcastle, Newcastle, New South Wales, Australia., Moffatt MF; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Cookson WO; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Wedzicha J; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Evans CM; Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA., Boucher RC; Marsico Lung Institute/Cystic Fibrosis and Pulmonary Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Kesimer M; Marsico Lung Institute/Cystic Fibrosis and Pulmonary Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Lieleg O; School of Engineering and Design, Department of Materials Engineering and.; Center for Protein Assemblies, Technical University of Munich, Munich, Germany., Mallia P; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Johnston SL; National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2022 Apr 15; Vol. 132 (8).

Low Serum Albumin Levels are Associated with Increased 30-Day Cardiopulmonary Complications, Reoperation, and Readmission Rates Following Total Shoulder Arthroplasty.

Autor: Lee D; The George Washington University School of Medicine and Health Sciences; The George Washington University., Lee R; The George Washington University School of Medicine and Health Sciences; The George Washington University., Cross MT; The George Washington University School of Medicine and Health Sciences; The George Washington University., Tran A; Department of Orthopaedic Surgery; The George Washington University., Kappa J; Department of Orthopaedic Surgery; The George Washington University., Moghtaderi S; Department of Orthopaedic Surgery; The George Washington University.

Publikováno v: The Iowa orthopaedic journal [Iowa Orthop J] 2019; Vol. 39 (2), pp. 27-34.