Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virus–Infected Cells and Liver to Identify Pathways Associated With Disease Development

Autor: Lupberger, Joachim, Croonenborghs, Tom, Roca Suarez, Armando Andres, Van Renne, Nicolaas, Jühling, Frank, Oudot, Marine A., Virzì, Alessia, Bandiera, Simonetta, Jamey, Carole, Meszaros, Gergö, Brumaru, Daniel, Mukherji, Atish, Durand, Sarah C., Heydmann, Laura, Verrier, Eloi R., El Saghire, Hussein, Hamdane, Nourdine, Bartenschlager, Ralf, Fereshetian, Shaunt, Ramberger, Evelyn, Sinha, Rileen, Nabian, Mohsen, Everaert, Celine, Jovanovic, Marko, Mertins, Philipp, Carr, Steven A., Chayama, Kazuaki, Dali-Youcef, Nassim, Ricci, Romeo, Bardeesy, Nabeel M., Fujiwara, Naoto, Gevaert, Olivier, Zeisel, Mirjam B., Hoshida, Yujin, Pochet, Nathalie, Baumert, Thomas F.

Publikováno v: In Gastroenterology August 2019 157(2):537-551

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery

Autor: Crouchet, Emilie, Bandiera, Simonetta, Fujiwara, Naoto, Li, Shen, El Saghire, Hussein, Fernández-Vaquero, Mirian, Riedl, Tobias, Sun, Xiaochen, Hirschfield, Hadassa, Jühling, Frank, Zhu, Shijia, Roehlen, Natascha, Ponsolles, Clara, Heydmann, Laura, Saviano, Antonio, Qian, Tongqi, Venkatesh, Anu, Lupberger, Joachim, Verrier, Eloi R., Sojoodi, Mozhdeh, Oudot, Marine A., Duong, François H. T., Masia, Ricard, Wei, Lan, Thumann, Christine, Durand, Sarah C., González-Motos, Victor, Heide, Danijela, Hetzer, Jenny, Nakagawa, Shigeki, Ono, Atsushi, Song, Won-Min, Higashi, Takaaki, Sanchez, Roberto, Kim, Rosa S., Bian, C. Billie, Kiani, Karun, Croonenborghs, Tom, Subramanian, Aravind, Chung, Raymond T., Straub, Beate K., Schuppan, Detlef, Ankavay, Maliki, Cocquerel, Laurence, Schaeffer, Evelyne, Goossens, Nicolas, Koh, Anna P., Mahajan, Milind, Nair, Venugopalan D., Gunasekaran, Ganesh, Schwartz, Myron E., Bardeesy, Nabeel, Shalek, Alex K., Rozenblatt-Rosen, Orit, Regev, Aviv, Felli, Emanuele, Pessaux, Patrick, Tanabe, Kenneth K., Heikenwälder, Mathias, Schuster, Catherine, Pochet, Nathalie, Zeisel, Mirjam B., Fuchs, Bryan C., Hoshida, Yujin, Baumert, Thomas F.

Publikováno v: Nature Communications
Nature Communications, 2021, 12 (1), pp.5525. ⟨10.1038/s41467-021-25468-9⟩
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.5525. ⟨10.1038/s41467-021-25468-9⟩

Chronic liver disease and hepatocellular carcinoma (HCC) are life-threatening diseases with limited treatment options. The lack of clinically relevant/tractable experimental models hampers therapeutic discovery. Here, we develop a simple and robust h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f0c52e28e4771781df271af268b8f8f4
https://hal.science/hal-03395220/document

miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis

Autor: Van Renne, Nicolaas, Roca Suarez, Armando Andres, Duong, Francois H T, Gondeau, Claire, Calabrese, Diego, Fontaine, Nelly, Ababsa, Amina, Bandiera, Simonetta, Croonenborghs, Tom, Pochet, Nathalie, De Blasi, Vito, Pessaux, Patrick, Piardi, Tullio, Sommacale, Daniele, Ono, Atsushi, Chayama, Kazuaki, Fujita, Masashi, Nakagawa, Hidewaki, Hoshida, Yujin, Zeisel, Mirjam B, Heim, Markus H, Baumert, Thomas F, Lupberger, Joachim

Publikováno v: Gut
Gut, BMJ Publishing Group, 2018, 67 (5), pp.953-962. ⟨10.1136/gutjnl-2016-312270⟩
Gut, 2018, 67 (5), pp.953-962. ⟨10.1136/gutjnl-2016-312270⟩

BACKGROUND AND AIMS: HCV infection is a leading risk factor of hepatocellular carcinoma (HCC). However, even after viral clearance, HCC risk remains elevated. HCV perturbs host cell signalling to maintain infection, and derailed signalling circuitry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cef9d0e8e7c883a581db990b750e1d68

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