Nanoparticle Delivery of Immunostimulatory Alu RNA for Cancer Immunotherapy.

Autor: Garland KM; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee., Kwiatkowski AJ; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee., Tossberg JT; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Crooke PS 3rd; Department of Mathematics, Vanderbilt University, Nashville, Tennessee., Aune TM; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee., Wilson JT; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.; Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee.

Publikováno v: Cancer research communications [Cancer Res Commun] 2023 Sep 08; Vol. 3 (9), pp. 1800-1809. Date of Electronic Publication: 2023 Sep 08 (Print Publication: 2023).

Increased Development of Th1, Th17, and Th1.17 Cells Under T1 Polarizing Conditions in Juvenile Idiopathic Arthritis.

Autor: Patrick AE; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, United States., Shoaff K; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, United States., Esmond T; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Patrick DM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Veterans Affairs, Nashville, TN, United States., Flaherty DK; Office of Research (OOR) Shared Resources Department, Vanderbilt University Medical Center, Nashville, TN, United States., Graham TB; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, United States., Crooke PS 3rd; Department of Mathematics, Vanderbilt University, Nashville, TN, United States., Thompson S; Department of Pediatrics, Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, United States., Aune TM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Jul 04; Vol. 13, pp. 848168. Date of Electronic Publication: 2022 Jul 04 (Print Publication: 2022).

Cutting Edge: Reduced Adenosine-to-Inosine Editing of Endogenous Alu RNAs in Severe COVID-19 Disease.

Autor: Crooke PS 3rd; Department of Mathematics, Vanderbilt University, Nashville, TN 37212., Tossberg JT; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37212; and., Porter KP; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37212; and., Aune TM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37212; and tom.aune@vumc.org.; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37212.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Apr 15; Vol. 206 (8), pp. 1691-1696. Date of Electronic Publication: 2021 Mar 29.

Adenosine-to-Inosine RNA Editing of Alu Double-Stranded (ds)RNAs Is Markedly Decreased in Multiple Sclerosis and Unedited Alu dsRNAs Are Potent Activators of Proinflammatory Transcriptional Responses.

Autor: Tossberg JT; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37212., Heinrich RM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37212., Farley VM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37212., Crooke PS 3rd; Department of Mathematics, Vanderbilt University, Nashville, TN 37212; and., Aune TM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37212; tom.aune@vumc.org.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37212.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 Nov 15; Vol. 205 (10), pp. 2606-2617. Date of Electronic Publication: 2020 Oct 12.

NERD-seq: a novel approach of Nanopore direct RNA sequencing that expands representation of non-coding RNAs.

Autor: Saville L; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, R3E3N4, Canada.; Paul Albrechtsen Research Institute, CCMB, Winnipeg, MB, R3E3N4, Canada.; Southern Alberta Genome Sciences Centre, University of Lethbridge, Lethbridge, AB, T1K3M4, Canada.; Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, AB, T1K3M4, Canada., Wu L; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, R3E3N4, Canada.; Paul Albrechtsen Research Institute, CCMB, Winnipeg, MB, R3E3N4, Canada., Habtewold J; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, R3E3N4, Canada.; Paul Albrechtsen Research Institute, CCMB, Winnipeg, MB, R3E3N4, Canada., Cheng Y; Southern Alberta Genome Sciences Centre, University of Lethbridge, Lethbridge, AB, T1K3M4, Canada.; Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, AB, T1K3M4, Canada., Gollen B; Southern Alberta Genome Sciences Centre, University of Lethbridge, Lethbridge, AB, T1K3M4, Canada.; Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, AB, T1K3M4, Canada., Mitchell L; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, R3E3N4, Canada.; Paul Albrechtsen Research Institute, CCMB, Winnipeg, MB, R3E3N4, Canada.; Southern Alberta Genome Sciences Centre, University of Lethbridge, Lethbridge, AB, T1K3M4, Canada.; Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, AB, T1K3M4, Canada., Stuart-Edwards M; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, R3E3N4, Canada.; Paul Albrechtsen Research Institute, CCMB, Winnipeg, MB, R3E3N4, Canada.; Southern Alberta Genome Sciences Centre, University of Lethbridge, Lethbridge, AB, T1K3M4, Canada.; Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, AB, T1K3M4, Canada., Haight T; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, R3E3N4, Canada.; Paul Albrechtsen Research Institute, CCMB, Winnipeg, MB, R3E3N4, Canada.; Southern Alberta Genome Sciences Centre, University of Lethbridge, Lethbridge, AB, T1K3M4, Canada.; Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, AB, T1K3M4, Canada., Mohajerani M; Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, AB, T1K3M4, Canada., Zovoilis A; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, R3E3N4, Canada. athanasios.zovoilis@umanitoba.ca.; Paul Albrechtsen Research Institute, CCMB, Winnipeg, MB, R3E3N4, Canada. athanasios.zovoilis@umanitoba.ca.; Southern Alberta Genome Sciences Centre, University of Lethbridge, Lethbridge, AB, T1K3M4, Canada. athanasios.zovoilis@umanitoba.ca.; Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, AB, T1K3M4, Canada. athanasios.zovoilis@umanitoba.ca.

Publikováno v: Genome biology [Genome Biol] 2024 Aug 28; Vol. 25 (1), pp. 233. Date of Electronic Publication: 2024 Aug 28.