Evaluation of expanded 2-aminobenzothiazole library as inhibitors of a model histidine kinase and virulence suppressors in Pseudomonas aeruginosa

Autor: Fihn, Conrad A., Lembke, Hannah K., Gaulin, Jeffrey, Bouchard, Patricia, Villarreal, Alex R., Penningroth, Mitchell R., Crone, Kathryn K., Vogt, Grace A., Gilbertsen, Adam J., Ayotte, Yann, Coutinho de Oliveira, Luciana, Serrano-Wu, Michael H., Drouin, Nathalie, Hung, Deborah T., Hunter, Ryan C., Carlson, Erin E.

Publikováno v: In Bioorganic Chemistry December 2024 153

An Extracellular, Ca²⁺‐Activated Nuclease (EcnA) Mediates Transformation in a Naturally Competent Archaeon.

Autor: Fonseca, Dallas R., Day, Leslie A., Crone, Kathryn K., Costa, Kyle C.

Publikováno v: Molecular Microbiology; Oct2024, Vol. 122 Issue 4, p477-490, 14p

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Evaluation of Expanded 2-Aminobenzothiazole Library for Inhibition of Pseudomonas aeruginosa Virulence Phenotypes.

Autor: Fihn CA; Department of Medicinal Chemistry, University of Minnesota, 308 Harvard Street SE, Minneapolis, Minnesota 55455, United States., Lembke HK; Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55454, United States., Gaulin J; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States., Bouchard P; NMX Research and Solution Inc., 500 Cartier Boulevard W., Suite 6000, Laval, Quebec, Canada, H1Y 2R1., Villarreal AR; Department of Microbiology & Immunology, University of Minnesota, 689 23rd Ave Se Minneapolis, Minnesota 55455, United States., Penningroth MR; Department of Microbiology & Immunology, University of Minnesota, 689 23rd Ave Se Minneapolis, Minnesota 55455, United States., Crone KK; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 321 Church Street SE, Minneapolis, Minnesota 55455, United States., Vogt GA; Department of Microbiology & Immunology, University of Minnesota, 689 23rd Ave Se Minneapolis, Minnesota 55455, United States., Gilbertsen AJ; Department of Microbiology & Immunology, University of Minnesota, 689 23rd Ave Se Minneapolis, Minnesota 55455, United States., Ayotte Y; NMX Research and Solution Inc., 500 Cartier Boulevard W., Suite 6000, Laval, Quebec, Canada, H1Y 2R1., de Oliveira LC; NMX Research and Solution Inc., 500 Cartier Boulevard W., Suite 6000, Laval, Quebec, Canada, H1Y 2R1., Serrano-Wu MH; 3 Point Bio LLC, 245 Main Street, Cambridge, Massachusetts 02142, United States., Drouin N; NMX Research and Solution Inc., 500 Cartier Boulevard W., Suite 6000, Laval, Quebec, Canada, H1Y 2R1., Hung DT; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States., Hunter RC; Department of Microbiology & Immunology, University of Minnesota, 689 23rd Ave Se Minneapolis, Minnesota 55455, United States., Carlson EE; Department of Medicinal Chemistry, University of Minnesota, 308 Harvard Street SE, Minneapolis, Minnesota 55455, United States.; Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55454, United States.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 321 Church Street SE, Minneapolis, Minnesota 55455, United States.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 10. Date of Electronic Publication: 2024 Jan 10.