Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Crohn disease/genetics"'
Autor:
W. A. Bemelman, Jochem H. Bernink, Lisette Krabbendam, Christianne J. Buskens, Chantal M. A. Kradolfer, Nienke J. E. Haverkate, Hergen Spits, M Becker, Balthasar A. Heesters
Publikováno v:
Nature communications, 12(1):5841. Nature Publishing Group
Nature Communications, 12(1):5841. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications, 12(1), 1. Nature Publishing Group
Nature Communications, 12(1):5841. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications, 12(1), 1. Nature Publishing Group
Phenotypic definition of helper ILC1 and NK cells is problematic due to overlapping markers. Recently we showed the identification of cytotoxic ILC3s characterized by expression of CD94. Here we analyse CD127+ ILCs and NK cells in intestinal lamina p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f083059747cc9d7bac97f9593c7a2022
https://pure.amc.nl/en/publications/cd127-cd94-innate-lymphoid-cells-expressing-granulysin-and-perforin-are-expanded-in-patients-with-crohns-disease(b96c4eec-38f0-428b-992c-5963bbe26c6d).html
https://pure.amc.nl/en/publications/cd127-cd94-innate-lymphoid-cells-expressing-granulysin-and-perforin-are-expanded-in-patients-with-crohns-disease(b96c4eec-38f0-428b-992c-5963bbe26c6d).html
Autor:
Grant W. Montgomery, Naomi R. Wray, Peter M. Visscher, Gillian Mahy, Graham L. Radford-Smith, Gerhard Moser, Sang Hong Lee, Lisa Bowdler, Jane M. Andrews, Krupa Krishnaprasad, Sally Bell, Guo-Bo Chen, Alissa Walsh, Ian C. Lawrance, Peter A. Bampton, Richard B. Gearry, Miles P. Sparrow, Lisa A. Simms, Susan J. Connor
Publikováno v:
BMC Medical Genetics, Vol 18, Iss 1, Pp 1-11 (2017)
International IBD Genetics Consortium & Andersen, V 2017, ' Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method ', BMC Medical Genetics, vol. 18, 94 . https://doi.org/10.1186/s12881-017-0451-2
BMC Medical Genetics
International IBD Genetics Consortium & Andersen, V 2017, ' Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method ', BMC Medical Genetics, vol. 18, 94 . https://doi.org/10.1186/s12881-017-0451-2
BMC Medical Genetics
Background Predicting risk of disease from genotypes is being increasingly proposed for a variety of diagnostic and prognostic purposes. Genome-wide association studies (GWAS) have identified a large number of genome-wide significant susceptibility l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f689475ccd6149a04efe94edaf5e53
http://link.springer.com/article/10.1186/s12881-017-0451-2
http://link.springer.com/article/10.1186/s12881-017-0451-2
Publikováno v:
The International IBD Genetics Consortium 2018, ' IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes ', Nature Communications, vol. 9, 2427 . https://doi.org/10.1038/s41467-018-04365-8
GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are perturbed by these variants, we generate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3062::e3fa251d337254dd71a55a25a8eb3d34
https://findresearcher.sdu.dk:8443/ws/files/141681759/IBD_risk_loci_are_enriched_in_multigenic_regulatory_modules_encompassing_putative_causative_genes.pdf
https://findresearcher.sdu.dk:8443/ws/files/141681759/IBD_risk_loci_are_enriched_in_multigenic_regulatory_modules_encompassing_putative_causative_genes.pdf
Publikováno v:
Nature Communications. 9
GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are perturbed by these variants, we generate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od________83::3be6efce47604f5760a2de246ff3c5e9
https://cris.maastrichtuniversity.nl/en/publications/bc2341b2-d3da-4a43-9fae-a4f70bd5b2ee
https://cris.maastrichtuniversity.nl/en/publications/bc2341b2-d3da-4a43-9fae-a4f70bd5b2ee
Autor:
Momozawa, Yukihide, Dmitrieva, Julia, Théâtre, Emilie, Deffontaine, Valérie, Rahmouni, Souad, Charloteaux, Benoît, Crins, François, Docampo, Elisa, Elansary, Mahmoud, Gori, Ann Stephan, Lecut, Christelle, Mariman, Rob, Mni, Myriam, Oury, Cécile, Altukhov, Ilya, Alexeev, Dmitry, Aulchenko, Yuri, Amininejad, Leila, Bouma, Gerd, Hoentjen, Frank, Löwenberg, Mark, Oldenburg, Bas, Pierik, Marieke J., Vander Meulen-De Jong, Andrea E., Van Der Woude, C. Janneke, Visschedijk, Marijn C., Lathrop, Mark, Hugot, Jean Pierre, Weersma, Rinse K., De Vos, Martine, Franchimont, Denis, Vermeire, Severine, Kubo, Michiaki, Louis, Edouard, Georges, Michel, Abraham, Clara, Achkar, Jean Paul, Ahmad, Tariq, Ananthakrishnan, Ashwin N., Andersen, Vibeke, Anderson, Carl A., Andrews, Jane M., Annese, Vito, Aumais, Guy, Baidoo, Leonard, Baldassano, Robert N., Bampton, Peter A., Barclay, Murray, Barrett, Jeffrey C., Bayless, Theodore M.
Publikováno v:
Nature Communications, 9:2427. Nature Publishing Group
Nature communications, 9(1):2427. Nature Publishing Group
Nature Communications, 9(1). Nature Publishing Group
Nature communications, 9(1):2427. Nature Publishing Group
Nature Communications, 9(1). Nature Publishing Group
GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are perturbed by these variants, we generate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9cad49a486ee429002b9525a7db72b49
https://cris.maastrichtuniversity.nl/en/publications/bc2341b2-d3da-4a43-9fae-a4f70bd5b2ee
https://cris.maastrichtuniversity.nl/en/publications/bc2341b2-d3da-4a43-9fae-a4f70bd5b2ee
Autor:
Renata D'Incà, Vlatka Zoldoš, Aleksandar Vojta, Jerko Štambuk, Gordan Lauc, Paula Dobrinić, Nicholas A. Kennedy, Ivana Samaržija, Mirna Šimurina, Genadij Razdorov, Jack Satsangi, Ana M. Dias, Marija Klasić, Dora Markulin, Nicholas T. Ventham, Anna Latiano, Ivan Biruš, Vito Annese, Salomé S. Pinho, Irena Trbojević-Akmačić
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-14 (2018)
2018, ' Promoter methylation of the MGAT3 and BACH2 genes correlates with the composition of the immunoglobulin G glycome in inflammatory bowel disease ', Clinical Epigenetics, vol. 10, pp. 75 . https://doi.org/10.1186/s13148-018-0507-y
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-14 (2018)
2018, ' Promoter methylation of the MGAT3 and BACH2 genes correlates with the composition of the immunoglobulin G glycome in inflammatory bowel disease ', Clinical Epigenetics, vol. 10, pp. 75 . https://doi.org/10.1186/s13148-018-0507-y
Background: Many genome- and epigenome-wide association studies (GWAS and EWAS) and studies of promoter methylation of candidate genes for inflammatory bowel disease (IBD) have demonstrated significant associations between genetic and epigenetic chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2520fd6d4006eba55ecd3e9fbea8c2c
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Richard Apps, Simon Mallal, Zabrina L. Brumme, Kelly A. Soderberg, Chanson J. Brumme, Ashley Moffett, Nelson L. Michael, Xue Zeng, James J. Goedert, Steven M. Wolinsky, Jonathan M. Carlson, Greg Q. Del Prete, Haoyan Chen, M. Anthony Moody, Yuko Yuki, Mina John, Susan Buchbinder, Jingyuan Fang, Gregory D. Kirk, Amy C. Weintrob, Steven G. Deeks, Florencia Pereyra, Xiaojiang Gao, Ronald J. Bosch, Thomas N. Denny, Jacques Fellay, Wilson Liao, George W. Nelson, Philip J. R. Goulder, Judy L. Stein, David Heckerman, Rasmi Thomas, Paul J. McLaren, Ying Qi, Jeffrey D. Lifson, Bruce D. Walker, Mary Carrington
Publikováno v:
Science, vol. 340, no. 6128, pp. 87-91
Science (New York, N.Y.), vol 340, iss 6128
Science (New York, N.Y.), vol 340, iss 6128
Thwarting HIV Multiple genome-wide association studies have revealed that human leukocyte antigen (HLA) genes of the major histocompatibility complex locus have the strongest impact on HIV. In particular, a single-nucleotide polymorphism 35 base pair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9f631ad271b89170e5d18f3042deb5
https://ora.ox.ac.uk/objects/uuid:91e91a3a-bc20-4503-948e-488edc324579
https://ora.ox.ac.uk/objects/uuid:91e91a3a-bc20-4503-948e-488edc324579
Autor:
Paal Skytt Andersen, Steffen Bank, Hans Jürgen Hoffmann, Natalia Pedersen, Johan Burisch, Jacob Sode, Stine Roug, Vibeke Andersen, Stine Ydegaard Turino, Ulla Vogel, Britt Kaiser Rasmussen, Sara Avlund, Julie Galsgaard, Shaista Rashid, Bjørn A. Nexø, Jacob Broder Brodersen, Thomas Bastholm Olesen
Publikováno v:
Bank, S, Andersen, P S, Burisch, J, Pedersen, N, Roug, S, Galsgaard, J, Turino, S Y, Brodersen, J B, Rashid, S, Rasmussen, B K, Avlund, S, Olesen, T B, Hoffmann, H J, Nexø, B A, Sode, J, Vogel, U & Andersen, V 2018, ' Genetically determined high activity of IL-12 and IL-18 in ulcerative colitis and TLR5 in Crohns disease were associated with non-response to anti-TNF therapy ', Pharmacogenomics Journal, vol. 18, no. 1, pp. 87-97 . https://doi.org/10.1038/tpj.2016.84
Bank, S, Andersen, P S, Burisch, J, Pedersen, N, Roug, S, Galsgaard, J, Turino, S Y, Brodersen, J B, Rashid, S, Rasmussen, B K, Avlund, S, Olesen, T B, Hoffmann, H J, Nexø, B A, Sode, J, Vogel, U & Andersen, V 2018, ' Genetically determined high activity of IL-12 and IL-18 in ulcerative colitis and TLR5 in Crohns disease were associated with non-response to anti-TNF therapy ', The Pharmacogenomics Journal, vol. 18, no. 1, pp. 87–97 . https://doi.org/10.1038/tpj.2016.84
Bank, S, Andersen, P S, Burisch, J, Pedersen, N, Roug, S, Galsgaard, J, Turino, S Y, Brodersen, J B, Rashid, S, Rasmussen, B K, Avlund, S, Olesen, T B, Hoffmann, H J, Nexø, B A, Sode, J, Vogel, U & Andersen, V 2018, ' Genetically determined high activity of IL-12 and IL-18 in ulcerative colitis and TLR5 in Crohns disease were associated with non-response to anti-TNF therapy ', The Pharmacogenomics Journal, vol. 18, no. 1, pp. 87–97 . https://doi.org/10.1038/tpj.2016.84
Anti-tumour necrosis factor-α (TNF-α) is used for treatment of severe cases of inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). However, one-third of the patients do not respond to the treatment. A rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085208ec1ac4f711e4a8bd5116d91b50
https://pubmed.ncbi.nlm.nih.gov/28139755
https://pubmed.ncbi.nlm.nih.gov/28139755
Autor:
Marianne R Spalinger, Jonas Zeitz, Luc Biedermann, Jean-Benoit Rossel, Michael C Sulz, Pascal Frei, Sylvie Scharl, Stephan R Vavricka, Michael Fried, Gerhard Rogler, Michael Scharl, Swiss IBD Cohort Study Group
Publikováno v:
PloS one, vol. 11, no. 7, pp. e0160215
PLoS ONE, Vol 11, Iss 7, p e0160215 (2016)
PLoS ONE
Plos One
PLoS ONE, Vol 11, Iss 7, p e0160215 (2016)
PLoS ONE
Plos One
Background Protein tyrosine phosphatase non-receptor type 22 (PTPN22) plays an important role in immune cell function and intestinal homeostasis. The single nucleotide polymorphism (SNP) rs2476601 within the PTPN22 gene locus results in aberrant func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392888d0f316a39aee956b9a91e29984
https://serval.unil.ch/notice/serval:BIB_9A5DBA31FA9B
https://serval.unil.ch/notice/serval:BIB_9A5DBA31FA9B
Publikováno v:
Scandinavian journal of gastroenterology, 38(Suppl. 239), 63-68. Informa Healthcare
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 38, 63-68. Taylor & Francis Group
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 38, 63-68. Taylor & Francis Group
Background: Inflammatory bowel disease (IBD) is a complex disorder with an aetiology that is onlypartly understood. Apart from environmental factors, inheritance contributes to IBD. Review: Family studies show an increased risk among family members o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2575d3c1c445ecdc2252b2424637b3
https://doi.org/10.1080/00855920310002717
https://doi.org/10.1080/00855920310002717