Is prokaryotic complexity limited by accelerated growth in regulatory overhead?

Autor: Croft, Larry J., Lercher, Martin J., Gagen, Michael J., Mattick, John S.

Increased biological complexity is generally associated with the addition of new genetic information, which must be integrated into the existing regulatory network that operates within the cell. General arguments on network control, as well as severa

Externí odkaz: http://arxiv.org/abs/q-bio/0311021

A transcriptional sketch of a primary human breast cancer by 454 deep sequencing

Autor: Pesole Graziano, Mignone Flavio, Callari Maurizio, Bonnal Raoul J, Askarian-Amiri Marjan, Rizzi Ermanno, Taft Ryan J, Croft Larry J, Soldà Giulia, Kim Namshin, Pelucchi Paride, Iacono Michele, Guffanti Alessandro, Bertalot Giovanni, Bernardi Luigi, Albertini Alberto, Lee Christopher, Mattick John S, Zucchi Ileana, De Bellis Gianluca

Publikováno v: BMC Genomics, Vol 10, Iss 1, p 163 (2009)

Abstract Background The cancer transcriptome is difficult to explore due to the heterogeneity of quantitative and qualitative changes in gene expression linked to the disease status. An increasing number of "unconventional" transcripts, such as novel

Externí odkaz: https://doaj.org/article/ee26970694194d49bf871f0ccca860ab

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The genome of the Wollemi pine, a critically endangered "living fossil" unchanged since the Cretaceous, reveals extensive ancient transposon activity.

Autor: Stevenson DW; The New York Botanical Garden, 2900 Southern Boulevard, Bronx, NY 10458, USA., Ramakrishnan S; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA., de Santis Alves C; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.; Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Coelho LA; Department of Epidemiology and Biostatistics, School of Public Health; Institute for Genomics in Health; Division of Infectious Diseases, Department of Medicine, and Department of Cell Biology, College of Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY 11203-2098, USA., Kramer M; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA., Goodwin S; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA., Ramos OM; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA., Eshel G; Center for Genomics & Systems Biology, New York University, New York, NY 10003, USA., Sondervan VM; Center for Genomics & Systems Biology, New York University, New York, NY 10003, USA., Frangos S; Center for Genomics & Systems Biology, New York University, New York, NY 10003, USA., Zumajo-Cardona C; The New York Botanical Garden, 2900 Southern Boulevard, Bronx, NY 10458, USA., Jenike K; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA., Ou S; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA.; Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA., Wang X; Purdue University, 610 Purdue Mall, West Lafayette, IN 47907, USA., Lee YP; Charles River Laboratories Australia, 17-19 Hi-Tech Ct, Kilsyth VIC 3137, Australia., Loke S; Charles River Laboratories Australia, 17-19 Hi-Tech Ct, Kilsyth VIC 3137, Australia., Rossetto M; Research Centre for Ecosystem Resilience, Royal Botanic Garden Sydney, Sydney, NSW 2000, Australia., McPherson H; National Herbarium of New South Wales, Australian Botanic Garden, Mount Annan, NSW 2567, Australia., Nigris S; Dipartimento di Biologia, Università degli studi di Padova, via U. Bassi 58/B, 35131 Padova, Italy; and Botanical Garden, Università degli studi di Padova, via Orto Botanico 15, 35123 Padova, Italy., Moschin S; Dipartimento di Biologia, Università degli studi di Padova, via U. Bassi 58/B, 35131 Padova, Italy; and Botanical Garden, Università degli studi di Padova, via Orto Botanico 15, 35123 Padova, Italy., Little DP; The New York Botanical Garden, 2900 Southern Boulevard, Bronx, NY 10458, USA., Katari MS; Center for Genomics & Systems Biology, New York University, New York, NY 10003, USA., Varala K; Purdue University, 610 Purdue Mall, West Lafayette, IN 47907, USA., Kolokotronis SO; Department of Epidemiology and Biostatistics, School of Public Health; Institute for Genomics in Health; Division of Infectious Diseases, Department of Medicine, and Department of Cell Biology, College of Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY 11203-2098, USA., Ambrose B; The New York Botanical Garden, 2900 Southern Boulevard, Bronx, NY 10458, USA., Croft LJ; School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia., Coruzzi GM; Center for Genomics & Systems Biology, New York University, New York, NY 10003, USA., Schatz M; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA., McCombie WR; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA., Martienssen RA; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.; Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 24. Date of Electronic Publication: 2023 Aug 24.