Zobrazeno 1 - 10 of 481 pro vyhledávání: '"Criswell La"'
1
The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression
Autor: Hung, T, Pratt, GA, Sundararaman, B, Townsend, MJ, Chaivorapol, C, Bhangale, T, Graham, RR, Ortmann, W, Criswell, LA, Yeo, GW, Behrens, TW
Publikováno v: Science (New York, N.Y.), vol 350, iss 6259
Autoantibodies target the RNA binding protein Ro60 in systemic lupus erythematosus (SLE) and Sjögren's syndrome. However, it is unclear whether Ro60 and its associated RNAs contribute to disease pathogenesis. We catalogued the Ro60-associated RNAs i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::af0aee56843c520b3ca5a306435e76aa
https://escholarship.org/uc/item/8kk9514h
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2
Genome-wide assessment of differential DNA methylation associated with autoantibody production in systemic lupus erythematosus
Autor: Criswell, Lindsey, Chung, Sharon, Chung, SA, Nititham, J, Elboudwarej, E, Quach, HL, Taylor, KE, Barcellos, LF, Criswell, LA
Publikováno v: Criswell, Lindsey; Chung, Sharon; Chung, SA; Nititham, J; Elboudwarej, E; Quach, HL; et al.(2015). Genome-wide assessment of differential DNA methylation associated with autoantibody production in systemic lupus erythematosus. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/0rk528jk
© 2015 Chung et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::d70a062128ab556738d7634c11752988
http://www.escholarship.org/uc/item/0rk528jk
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3
Recent Advances in the Genetics of Systemic Sclerosis: Toward Biological and Clinical Significance
Autor: Criswell, Lindsey, Korman, BD, Criswell, LA
Publikováno v: Criswell, Lindsey; Korman, BD; & Criswell, LA. (2015). Recent Advances in the Genetics of Systemic Sclerosis: Toward Biological and Clinical Significance. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/98t88981
© 2015, The Author(s).Significant advances have been made in understanding the genetic basis of systemic sclerosis (SSc) in recent years. Genomewide association and other large-scale genetic studies have identified 30 largely immunity-related genes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::d92dbec54505e572e6653be0be3fb64f
http://www.escholarship.org/uc/item/98t88981
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4
Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus
Autor: Criswell, Lindsey, Kariuki, SN, Ghodke-Puranik, Y, Dorschner, JM, Chrabot, BS, Kelly, JA, Tsao, BP, Kimberly, RP, Alarcón-Riquelme, ME, Jacob, CO, Criswell, LA
Publikováno v: Criswell, Lindsey; Kariuki, SN; Ghodke-Puranik, Y; Dorschner, JM; Chrabot, BS; Kelly, JA; et al.(2014). Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/2w55w7h0
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by inflammation of multiple organ systems and dysregulated interferon responses. SLE is both genetically and phenotypically heterogeneous, greatly reducing the power of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::0e55997e44e7d33caaf92f8d26934cba
http://www.escholarship.org/uc/item/2w55w7h0
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5
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region
Autor: Criswell, Lindsey, Armstrong, DL, Zidovetzki, R, Alarcón-Riquelme, ME, Tsao, BP, Criswell, LA, Kimberly, RP, Harley, JB, Sivils, KL, Vyse, TJ, Gaffney, PM
Publikováno v: Criswell, Lindsey; Armstrong, DL; Zidovetzki, R; Alarcón-Riquelme, ME; Tsao, BP; Criswell, LA; et al.(2014). GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/07f1r0h5
In a genome-wide association study (GWAS) of individuals of European ancestry afflicted with systemic lupus erythematosus (SLE) the extensive utilization of imputation, step-wise multiple regression, lasso regularization and increasing study power by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::7cbce16e2ed4a7d2884a9a4b8f585a81
http://www.escholarship.org/uc/item/07f1r0h5
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6
The influence of polygenic risk scores on heritability of anti-CCP level in RA
Autor: Criswell, Lindsey, Cui, J, Taylor, KE, Lee, YC, Källberg, H, Weinblatt, ME, Coblyn, JS, Klareskog, L, Criswell, LA, Gregersen, PK, Shadick, NA
Publikováno v: Criswell, Lindsey; Cui, J; Taylor, KE; Lee, YC; Källberg, H; Weinblatt, ME; et al.(2014). The influence of polygenic risk scores on heritability of anti-CCP level in RA. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/51k8z4zz
The objective of this study was to study genetic factors that influence quantitative anticyclic citrullinated peptide (anti-CCP) antibody levels in RA patients. We carried out a genome-wide association study (GWAS) meta-analysis using 1975 anti-CCP+
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::0e2b6f80ba68415c64fecb864267e3ee
http://www.escholarship.org/uc/item/51k8z4zz
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7
Trans-Ancestral Studies Fine Map the SLE-Susceptibility Locus TNFSF4
Autor: Criswell, Lindsey, Manku, H, Langefeld, CD, Guerra, SG, Malik, TH, Alarcon-Riquelme, M, Anaya, JM, Bae, SC, Boackle, SA, Brown, EE, Criswell, LA
Publikováno v: Criswell, Lindsey; Manku, H; Langefeld, CD; Guerra, SG; Malik, TH; Alarcon-Riquelme, M; et al.(2013). Trans-Ancestral Studies Fine Map the SLE-Susceptibility Locus TNFSF4. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/3m73501p
We previously established an 80 kb haplotype upstream of TNFSF4 as a susceptibility locus in the autoimmune disease SLE. SLE-associated alleles at this locus are associated with inflammatory disorders, including atherosclerosis and ischaemic stroke.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::d62d450b6a2faee685b598765a56bbef
http://www.escholarship.org/uc/item/3m73501p
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8
Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus
Autor: Criswell, Lindsey, McCune, Joseph, Sacre, K, Criswell, LA, McCune, JM
Publikováno v: Criswell, Lindsey; McCune, Joseph; Sacre, K; Criswell, LA; & McCune, JM. (2012). Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/9qv8s4pc
Introduction: Plasmacytoid dendritic cells (pDCs) constitutively express two members of the Toll-like receptor (TLR) family, TLR-9 and TLR-7, through which they can be stimulated to produce high levels of interferon (IFN)-α, a key mediator of the pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::7929bfa113baa3a36546ee57f9273ffd
http://www.escholarship.org/uc/item/9qv8s4pc
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10
Factor V Leiden and thrombosis in patients with systemic lupus erythematosus: a meta-analysis
Autor: Kaiser, R, Barton, JL, Chang, M, Catanese, JJ, Li, Y, Begovich, AB, Criswell, LA
Publikováno v: Genes and immunity, vol 10, iss 5
The aim of this study was to perform a meta-analysis of the association between the factor V Leiden polymorphism (FVL) and thrombosis among patients with systemic lupus erythematosus (SLE) and/or antiphospholipid antibody (aPL) positivity. Included s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::832930a4b9e9bb3976eaf05d2143d7ba
https://escholarship.org/uc/item/7d0408qn
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