Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Cristopher Z. Schneider"'
Autor:
Diógenes Santiago Santos, Zilpa Adriana Sánchez-Quitian, Luiz Augusto Basso, Carlos Bloch Junior, Walter Filgueira de Azevedo Junior, Cristopher Z. Schneider, Rodrigo G. Ducati
Publikováno v:
Journal of Structural Biology. 169:413-423
The emergence of drug-resistant strains of Mycobacterium tuberculosis , the causative agent of tuberculosis, has exacerbated the treatment and control of this disease. Cytidine deaminase (CDA) is a pyrimidine salvage pathway enzyme that recycles cyti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9a65abe427d916bb825f321893459b
https://doi.org/10.1016/j.jsb.2009.12.019
https://doi.org/10.1016/j.jsb.2009.12.019
Autor:
Luiz Augusto Basso, Isabel Cristina Ribas Werlang, Mario Sergio Palma, Cristopher Z. Schneider, Diógenes Santiago Santos, Jordana Dutra de Mendonça
Publikováno v:
Microbiology. 155:2652-2663
Tuberculosis remains the major cause of mortality due to a bacterial pathogen,Mycobacterium tuberculosis. The molecular mechanisms of infection and persistence have not been completely elucidated for this pathogen. Studies involving nucleoid-associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a693df807d2826b47e38f6b750466b
https://doi.org/10.1099/mic.0.030148-0
https://doi.org/10.1099/mic.0.030148-0
Autor:
Walter Filgueira de Azevedo, Luiz Augusto Basso, Cristopher Z. Schneider, Ana Luiza Vivan, Rafael Andrade Caceres, Diógenes Santiago Santos, Luis Fernando Saraiva Macedo Timmers
Publikováno v:
Journal of Molecular Modeling. 14:427-434
Bacterial cytidylate kinase or cytidine monophosphate kinase (CMP kinase) catalyses the phosphoryl transfer from ATP to CMP and dCMP, resulting in the formation nucleoside diphosphates. In eukaryotes, CMP/UMP kinase catalyses the conversion of UMP an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86fe8e1ef138bc5b2eb516cca2102162
https://doi.org/10.1007/s00894-008-0291-2
https://doi.org/10.1007/s00894-008-0291-2
Autor:
Luiz Gonzaga de França Lopes, André dos Santos Junior, André Arigony Souto, Maria M. Campos, Cristopher Z. Schneider, Luiz Augusto Basso, Diógenes Santiago Santos, Valnês S. Rodrigues-Junior, João B. Calixto, Anderson Jader dos Santos, Eduardo H.S. Sousa
Publikováno v:
Repositório Institucional PUCRS
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
We have previously demonstrated a potent in vitro inhibitory activity for two pentacyano(isoniazid)ferrate(II) compounds, namely IQG-607 and IQG-639, against the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase enzyme. In this study, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07276417b3b02dbe46fe60c5708e0649
Autor:
Mario Sergio Palma, Cristopher Z. Schneider, Diógenes Santiago Santos, Luiz Augusto Basso, Gisele Biazus
Publikováno v:
Protein expression and purification. 66(2)
Human tuberculosis (TB) is a major cause of morbidity and mortality worldwide, especially in poor and developing countries. Moreover, the emergence of Mycobacterium tuberculosis strains resistant to first- and second-line anti-TB drugs raises the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9c6a27d7ef8eb4739e1c9d6026ab66
https://pubmed.ncbi.nlm.nih.gov/19362594
https://pubmed.ncbi.nlm.nih.gov/19362594
Autor:
Cristopher Z. Schneider, Diógenes Santiago Santos, Caroline Thum, Luiz Augusto Basso, Mario Sergio Palma
The Mycobacterium tuberculosis cmk gene, predicted to encode a CMP kinase (CMK), was cloned and expressed, and its product was purified to homogeneity. Steady-state kinetics confirmed that M. tuberculosis CMK is a monomer that preferentially phosphor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c415692839aae8e5ddd9f8ba62d979a
https://europepmc.org/articles/PMC2668428/
https://europepmc.org/articles/PMC2668428/
Publikováno v:
Journal of bacteriology. 190(1)
Chorismate mutase (CM) catalyzes the rearrangement of chorismate to prephenate in the biosynthetic pathway that forms phenylalanine and tyrosine in bacteria, fungi, plants, and apicomplexan parasites. Since this enzyme is absent from mammals, it repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3418a78712f3f3fad4339171adc3e6
https://pubmed.ncbi.nlm.nih.gov/17965159
https://pubmed.ncbi.nlm.nih.gov/17965159
Autor:
Diógenes Santiago Santos, Luiz Augusto Basso, Walter Filgueira de Azevedo, Cristopher Z. Schneider, Márcio Vinícius Bertacini Dias, Ana Luiza Vivan
Publikováno v:
Acta crystallographica. Section F, Structural biology and crystallization communications. 62(Pt 4)
Tuberculosis remains the leading cause of mortality arising from a bacterial pathogen (Mycobacterium tuberculosis). There is an urgent need for the development of new antimycobacterial agents. The aromatic amino-acid pathway is essential for the surv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796a8b3703d3c3fdc663eedc99a04ba4
https://pubmed.ncbi.nlm.nih.gov/16582484
https://pubmed.ncbi.nlm.nih.gov/16582484