Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors

Autor: Monica-Cornelia Sardaru, Anda Mihaela Craciun, Cristina-Maria Al Matarneh, Isabela Andreea Sandu, Roxana Maria Amarandi, Lacramioara Popovici, Catalina Ionica Ciobanu, Dragos Peptanariu, Mariana Pinteala, Ionel I. Mangalagiu, Ramona Danac

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1581-1595 (2020)

A potential microtubule destabilising series of new indolizine derivatives was synthesised and tested for their anticancer activity against a panel of 60 human cancer cell lines. Compounds 11a, 11b, 15a, and 15j showed a broad spectrum of growth inhi

Externí odkaz: https://doaj.org/article/991624767b6e4e398dd822986eb52e4d

Design, Synthesis, Molecular Modelling and Anticancer Activities of New Fused Phenanthrolines

Autor: Cristina Maria Al Matarneh, Roxana Maria Amarandi, Anda Mihaela Craciun, Ionel I. Mangalagiu, Gheorghita Zbancioc, Ramona Danac

Publikováno v: Molecules, Vol 25, Iss 3, p 527 (2020)

Three series of fused pyrrolophenanthroline derivatives were designed as analogues of phenstatin and synthesized in two steps starting with 1,7-phenanthroline, 4,7-phenanthroline and 1,10-phenanthroline, respectively. Two (Compounds 8a and 11c) of th

Externí odkaz: https://doaj.org/article/48871a6278184bd48a119ecb4868ff4e

Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors

Autor: Catalina Ionica Ciobanu, Ionel I. Mangalagiu, Lacramioara Popovici, Monica-Cornelia Sardaru, Ramona Danac, Mariana Pinteala, Dragos Peptanariu, Anda Mihaela Craciun, Isabela Andreea Sandu, Cristina-Maria Al Matarneh, Roxana Maria Amarandi

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1581-1595 (2020)

A potential microtubule destabilising series of new indolizine derivatives was synthesised and tested for their anticancer activity against a panel of 60 human cancer cell lines. Compounds 11a, 11b, 15a, and 15j showed a broad spectrum of growth inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b833b8ad50cd6f730714b31d63c534
https://doi.org/10.1080/14756366.2020.1801671

Fused pyrrolo-pyridines and pyrrolo-(iso)quinoline as anticancer agents

Autor: Dorina Amariucai-Mantu, Vasilichia Antoci, Monica Cornelia Sardaru, Cristina Maria Al Matarneh, Ionel Mangalagiu, Ramona Danac

Publikováno v: Physical Sciences Reviews.

This work emphasizes the synthesis strategies and antiproliferative related properties of fused pyrrolo-pyridine (including indolizine and azaindoles) and pyrrolo-(iso)quinoline derivatives recently reported in literature.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5030c8b31436d89a51e3d7e356cabe2
https://doi.org/10.1515/psr-2021-0030

New Library of Iodo-Quinoline Derivatives Obtained by an Alternative Synthetic Pathway and Their Antimicrobial Activity

Autor: Cristina Maria Al-Matarneh, Alina Nicolescu, Ioana Cristina Marinaş, Mădalina Diana Găboreanu, Sergiu Shova, Andrei Dascălu, Mihaela Silion, Mariana Pinteală

Publikováno v: Molecules, Vol 29, Iss 4, p 772 (2024)

6-Iodo-substituted carboxy-quinolines were obtained using a one-pot, three-component method with trifluoroacetic acid as a catalyst under acidic conditions. Iodo-aniline, pyruvic acid and 22 phenyl-substituted aldehydes (we varied the type and number

Externí odkaz: https://doaj.org/article/54381c090dd54bb7ac8daaa8d6225d61