Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Cristina di Giorgio"'
Autor:
Michele Biagioli, Cristina Di Giorgio, Elva Morretta, Rachele Bellini, Carmen Massa, Ginevra Urbani, Martina Bordoni, Silvia Marchianò, Ginevra Lachi, Valentina Sepe, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci
Publikováno v:
Pharmacological Research, Vol 208, Iss , Pp 107403- (2024)
Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are chronic disorders characterized by dysregulated immune response and persistent inflammation. Recent studies suggest that bile acid receptors, particularly GPBAR1
Externí odkaz:
https://doaj.org/article/d946a7733055458a933df16c259e76aa
Autor:
Claudia Finamore, Simona De Marino, Chiara Cassiano, Giuliano Napolitano, Pasquale Rapacciuolo, Silvia Marchianò, Michele Biagioli, Rosalinda Roselli, Cristina Di Giorgio, Carmen Festa, Stefano Fiorucci, Angela Zampella
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
BAR502, a bile acid analogue, is active as dual FXR/GPBAR1 agonist and represents a promising lead for the treatment of cholestasis and NASH. In this paper we report the synthesis and the biological evaluation of a library of hybrid compounds prepare
Externí odkaz:
https://doaj.org/article/66a1ede6d3ce454db68ec5a259f39f5f
Publikováno v:
Cells, Vol 13, Iss 19, p 1650 (2024)
Primary sclerosing cholangitis (PSC) is a rare, chronic liver disease with no approved therapies. The ursodeoxycholic acid (UDCA) has been widely used, although there is no evidence that the use of UDCA delays the time to liver transplant or increase
Externí odkaz:
https://doaj.org/article/8c33c16252b149838b750ac30deaed77
Publikováno v:
Cells, Vol 13, Iss 18, p 1580 (2024)
Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disorder characterized by progressive cholestatic that, if untreated, can progress to liver fibrosis, cirrhosis and liver decompensation requiring liver transplant. Although the pathogen
Externí odkaz:
https://doaj.org/article/61f7122acc434a168e237e668107b7ca
Autor:
Silvia Marchianò, Michele Biagioli, Martina Bordoni, Elva Morretta, Cristina Di Giorgio, Valentina Vellecco, Rosalinda Roselli, Rachele Bellini, Carmen Massa, Luigi Cari, Ginevra Urbani, Patrizia Ricci, Maria Chiara Monti, Antonino Giordano, Vincenzo Brancaleone, Mariarosaria Bucci, Angela Zampella, Eleonora Distrutti, Enrico Cieri, Giuseppe Cirino, Stefano Fiorucci
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 23 (2023)
Background Patients with nonalcoholic fatty liver disease are at increased risk to develop atherosclerotic cardiovascular diseases. FXR and GPBAR1 are 2 bile acid–activated receptors exploited in the treatment of nonalcoholic fatty liver disease: w
Externí odkaz:
https://doaj.org/article/e9d3bf92020f42c1aa2371c79a9f989c
Autor:
Silvia Marchianò, Michele Biagioli, Elva Morretta, Cristina Di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Ginevra Urbani, Carmen Massa, Maria Chiara Monti, Angela Zampella, Eleonora Distrutti, Stefano Fiorucci
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Non-alcoholic steatosis (NAFLD) and steatohepatitis (NASH) are two highly prevalent human disorders for which therapy remains suboptimal. Bile acids are signaling molecules acting on two main receptors the Farnesoid-x-receptor (FXR) and G pr
Externí odkaz:
https://doaj.org/article/61d1d9e67bd343308f5c4b385fc6c579
Autor:
Bianca Fiorillo, Rosalinda Roselli, Claudia Finamore, Michele Biagioli, Cristina di Giorgio, Martina Bordoni, Paolo Conflitti, Silvia Marchianò, Rachele Bellini, Pasquale Rapacciuolo, Chiara Cassiano, Vittorio Limongelli, Valentina Sepe, Bruno Catalanotti, Stefano Fiorucci, Angela Zampella
Publikováno v:
ACS Omega, Vol 8, Iss 47, Pp 45163-45163 (2023)
Externí odkaz:
https://doaj.org/article/0149ba2d1b3e46bdaa290fce321d9505
Autor:
Cristina Di Giorgio, Rachele Bellini, Antonio Lupia, Carmen Massa, Martina Bordoni, Silvia Marchianò, Rosalinda Rosselli, Valentina Sepe, Pasquale Rapacciuolo, Federica Moraca, Elva Morretta, Patrizia Ricci, Ginevra Urbani, Maria Chiara Monti, Michele Biagioli, Eleonora Distrutti, Bruno Catalanotti, Angela Zampella, Stefano Fiorucci
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionThe leukemia inhibitory factor (LIF), is a cytokine belonging to IL-6 family, whose overexpression correlate with poor prognosis in cancer patients, including pancreatic ductal adenocarcinoma (PDAC). LIF signaling is mediate by its bindin
Externí odkaz:
https://doaj.org/article/f1f478c3461f4a5a93b84a4cf5ca47e2
Autor:
Cristina Di Giorgio, Silvia Marchianò, Elisabetta Marino, Michele Biagioli, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Ginevra Urbani, Angela Zampella, Eleonora Distrutti, Annibale Donini, Luigina Graziosi, Stefano Fiorucci
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Gastric cancer (GC) is the third cause of cancer-related mortality worldwide. Nevertheless, because GC screening programs are not cost-effective, most patients receive diagnosis in the advanced stages, when surgical options are limited. Peritoneal di
Externí odkaz:
https://doaj.org/article/e1a292506417492fa1c83108bae4988b
Autor:
Stefano Fiorucci, Pasquale Rapacciuolo, Bianca Fiorillo, Rosalinda Roselli, Silvia Marchianò, Cristina Di Giorgio, Martina Bordoni, Rachele Bellini, Chiara Cassiano, Paolo Conflitti, Bruno Catalanotti, Vittorio Limongelli, Valentina Sepe, Michele Biagioli, Angela Zampella
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are two highly prevalent human diseases caused by excessive fat deposition in the liver. Although multiple approaches have been suggested, NAFLD/NASH remains an unmet cl
Externí odkaz:
https://doaj.org/article/a6792e07fe39402882b5e47cfb1a7855