Tracking matricellular protein SPARC in extracellular vesicles as a non-destructive method to evaluate lipid-based antifibrotic treatments

Autor: Cristina Zivko, Kathrin Fuhrmann, Gregor Fuhrmann, Paola Luciani

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)

A method is developed to isolate and characterize extracellular vesicles (EVs) from human hepatic stellate cells and proteomics reveals that the matricellular protein SPARC may be used as an EV marker after lipid-based antifibrotic treatment.

Externí odkaz: https://doaj.org/article/0029307714494d988b114ca1080d79a8

Generation and Characterization of a Human-Derived and Induced Pluripotent Stem Cell (iPSC) Line from an Alzheimer’s Disease Patient with Neuropsychiatric Symptoms

Autor: Ram Sagar, Cristina Zivko, Ariadni Xydia, David C. Weisman, Constantine G. Lyketsos, Vasiliki Mahairaki

Publikováno v: Biomedicines, Vol 11, Iss 12, p 3313 (2023)

Agitation is one of the most eminent characteristics of neuropsychiatric symptoms (NPS) affecting people living with Alzheimer’s and Dementia and has serious consequences for patients and caregivers. The current consensus is that agitation results,

Externí odkaz: https://doaj.org/article/b7132e34c7844bf5a366703f7539e940

Lipid-based nanoparticles and RNA as innovative neuro-therapeutics

Autor: Maria Tsakiri, Cristina Zivko, Costas Demetzos, Vasiliki Mahairaki

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

RNA-delivery is a promising tool to develop therapies for difficult to treat diseases such as neurological disorders, by silencing pathological genes or expressing therapeutic proteins. However, in many cases RNA delivery requires a vesicle that coul

Externí odkaz: https://doaj.org/article/933d022c048c4d1c95795ac56e722295

Formulating elafibranor and obeticholic acid with phospholipids decreases drug-induced association of SPARC to extracellular vesicles from LX-2 human hepatic stellate cells

Autor: Cristina Zivko, Finja Witt, Andreas Koeberle, Gregor Fuhrmann, Paola Luciani

Publikováno v: Zivko, Cristina; Witt, Finja; Koeberle, Andreas; Fuhrmann, Gregor; Luciani, Paola (2023). Formulating elafibranor and obeticholic acid with phospholipids decreases drug-induced association of SPARC to extracellular vesicles from LX-2 human hepatic stellate cells. European journal of pharmaceutics and biopharmaceutics, 182, pp. 32-40. Elsevier 10.1016/j.ejpb.2022.11.025

Chronic hepatic diseases often compromise liver function and are directly responsible for up to two million yearly deaths world-wide. There are yet no treatment options to solve this global medical need. Experimental drugs elafibranor (Ela) and obeti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde5892cb9a58a070bf1138b6d623510

Synergy of Phospholipid—Drug Formulations Significantly Deactivates Profibrogenic Human Hepatic Stellate Cells

Autor: Florian Weber, Cristina Zivko, Gina Valentino, Lorine Brülisauer, Paola Luciani

Publikováno v: Valentino, Gina; Zivko, Cristina; Weber, Florian; Brülisauer, Lorine; Luciani, Paola (2019). Synergy of Phospholipid—Drug Formulations Significantly Deactivates Profibrogenic Human Hepatic Stellate Cells. Pharmaceutics, 11(12) MDPI 10.3390/pharmaceutics11120676
Pharmaceutics
Volume 11
Issue 12

The pivotal role of hepatic stellate cells (HSCs) in orchestrating the bidirectional process of progression and regression of liver fibrosis makes them an ideal target for exploring new antifibrotic therapies. Essential phospholipids (EPLs), with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f7e00a6bf4872f7b96d3db43d82dfa
https://boris.unibe.ch/137020/1/pharmaceutics-11-00676.pdf