Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Cristina Visentin"'
Autor:
Javier Garcia-Pardo, Andrea Bartolomé-Nafría, Antonio Chaves-Sanjuan, Marcos Gil-Garcia, Cristina Visentin, Martino Bolognesi, Stefano Ricagno, Salvador Ventura
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
The authors report the Cryo-EM of hnRNPDL-2 fibrils. The structure highlights features of a functional amyloid associated with limb-girdle muscular dystrophy-3 and explains how alternative splicing controls the assembly of this ribonucleoprotein.
Externí odkaz:
https://doaj.org/article/0400f8a9115f463985ae38d8abefa7e7
Autor:
Stefano Rosa, Andrea Tagliani, Chiara Bertaso, Luca Tadini, Cristina Visentin, Louise Jane Gourlay, Sabrina Pricl, Lucia Feni, Sara Pellegrino, Paolo Pesaresi, Simona Masiero
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Genetically-encoded combinatorial peptide libraries are convenient tools to identify peptides to be used as therapeutics, antimicrobials and functional synthetic biology modules. Here, we report the identification and characterization of a cyclic pep
Externí odkaz:
https://doaj.org/article/856190be0ecb44fb812a33bb4087f433
Autor:
Diletta Ami, Barbara Sciandrone, Paolo Mereghetti, Jacopo Falvo, Tiziano Catelani, Cristina Visentin, Paolo Tortora, Salvador Ventura, Antonino Natalello, Maria Elena Regonesi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 943 (2021)
Amyloid aggregation of human ataxin-3 (ATX3) is responsible for spinocerebellar ataxia type 3, which belongs to the class of polyglutamine neurodegenerative disorders. It is widely accepted that the formation of toxic oligomeric species is primarily
Externí odkaz:
https://doaj.org/article/25dd008cda1b4f47b771c5d2fdb42316
Autor:
Cristina Visentin, Loana Musso, Luca Broggini, Francesca Bonato, Rosaria Russo, Claudia Moriconi, Martino Bolognesi, Elena Miranda, Sabrina Dallavalle, Daniele Passarella, Stefano Ricagno
Publikováno v:
Life, Vol 10, Iss 7, p 111 (2020)
Familial encephalopathy with neuroserpin inclusion bodies (FENIB) is a severe and lethal neurodegenerative disease. Upon specific point mutations in the SERPINI1gene-coding for the human protein neuroserpin (NS) the resulting pathologic NS variants p
Externí odkaz:
https://doaj.org/article/fdb1d61078384b278802ad76ea67ae50
Autor:
Cristina Visentin, Luca Broggini, Benedetta Maria Sala, Rosaria Russo, Alberto Barbiroli, Carlo Santambrogio, Simona Nonnis, Anatoly Dubnovitsky, Martino Bolognesi, Elena Miranda, Adnane Achour, Stefano Ricagno
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9, p 3235 (2020)
Neuroserpin (NS) is a member of the serine protease inhibitors superfamily. Specific point mutations are responsible for its accumulation in the endoplasmic reticulum of neurons that leads to a pathological condition named familial encephalopathy wit
Externí odkaz:
https://doaj.org/article/b4f1f4887daf4073bafdfe98de5943d7
Autor:
Cristina Visentin, Susanna Navarro, Gianvito Grasso, Maria Elena Regonesi, Marco Agostino Deriu, Paolo Tortora, Salvador Ventura
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2151 (2018)
The protein ataxin-3 contains a polyglutamine stretch that triggers amyloid aggregation when it is expanded beyond a critical threshold. This results in the onset of the spinocerebellar ataxia type 3. The protein consists of the globular N-terminal J
Externí odkaz:
https://doaj.org/article/7cb5f567fb6f4d6086fc020d31fafafa
Autor:
Marcella Bonanomi, Cristina Visentin, Gaetano Invernizzi, Paolo Tortora, Maria Elena Regonesi
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129727 (2015)
Ataxin-3 (AT3) is a deubiquitinating enzyme that triggers an inherited neurodegenerative disorder, spinocerebellar ataxia type 3, when its polyglutamine (polyQ) stretch close to the C-terminus exceeds a critical length. AT3 variants carrying the expa
Externí odkaz:
https://doaj.org/article/55b061f9a2d2470b9997acc290be4a3b
Autor:
Stefano Ricagno, Cristina Visentin, Annamaria Fra, Elena Miranda, Giovanna Galliciotti, Emanuela D'Acunto, Mauro Manno
Publikováno v:
Cellular and Molecular Life Sciences
Neuroserpin is a serine protease inhibitor identified in a search for proteins implicated in neuronal axon growth and synapse formation. Since its discovery over 30 years ago, it has been the focus of active research. Many efforts have concentrated i
Autor:
Cristina Visentin, Antonio Chaves-Sanjuan, Javier Garcia-Pardo, Andrea Bartolomé-Nafría, Salvador Ventura, Martino Bolognesi, Stefano Ricagno, Marcos Gil-Garcia
hnRNPDL is a ribonucleoprotein (RNP) involved in transcription and RNA-processing, with missense mutations causing limb-girdle muscular dystrophy-3 (LGMDD3). Mammalian-specific alternative splicing (AS) renders three natural isoforms, hnRNPDL-2 being
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b8b6e2cbce5195983e32b4f25a114ae
https://doi.org/10.1101/2022.08.24.503855
https://doi.org/10.1101/2022.08.24.503855
Autor:
Emanuele Scalone, Luca Broggini, Cristina Visentin, Davide Erba, Fran Bačić Toplek, Kaliroi Peqini, Sara Pellegrino, Stefano Ricagno, Cristina Paissoni, Carlo Camilloni
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Protein aggregation into amyloid fibrils is the archetype of aberrant biomolecular self-assembly processes, with more than 50 associated diseases that are mostly uncurable. Understanding aggregation mechanisms is thus of fundamental importance and go