Memory stem T cells modified with a redesigned CD30‐chimeric antigen receptor show an enhanced antitumor effect in Hodgkin lymphoma

Autor: Carmen Alvarez‐Fernández, Laura Escribà‐Garcia, AC Caballero, Eva Escudero‐López, Cristina Ujaldón‐Miró, Rosanna Montserrat‐Torres, Paula Pujol‐Fernández, Jorge Sierra, Javier Briones

Publikováno v: Clinical & Translational Immunology, Vol 10, Iss 4, Pp n/a-n/a (2021)

Abstract Objectives Adoptive cell therapy (ACT) with mature T cells modified with a chimeric antigen receptor has demonstrated improved outcome for B‐cell malignancies. However, its application for others such as Hodgkin lymphoma remains a clinical

Externí odkaz: https://doaj.org/article/b79e9363db8f4e288e1a2e4cc450e55f

High CAR intensity of expression confers enhanced antitumor effect against lymphoma without functional exhaustion

Autor: Ana Carolina Caballero, Laura Escribà-Garcia, Paula Pujol-Fernández, Eva Escudero-López, Cristina Ujaldón-Miró, Rosanna Montserrat-Torres, Jorge Sierra, Carmen Alvarez-Fernández, Javier Briones

Publikováno v: CANCER GENE THERAPY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Identifying factors that ameliorates clinical outcomes following CART therapy represents an unmet need. We hypothesized that CAR expression level would have a significant impact on CART efficacy and tested this with CAR30(+) T-SCM(-)LIKE enriched cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de1e2add5ffa3d890fe7e8a3f1aaa4c
https://pubmed.ncbi.nlm.nih.gov/36460806

CAR-T Cells with High CAR Expression Intensity Have Improved In Vitro and In Vivo Anti-Lymphoma Effect without Functional Exhaustion

Autor: Paula Pujol-Fernández, Rosanna Montserrat, Laura Escribà-Garcia, Carmen Alvarez-Fernández, Jorge Sierra, Ana Carolina Carolina Caballero González, Eva Escudero-López, Cristina Ujaldón-Miró, Javier Briones

Publikováno v: Blood. 136:34-34

Background While immunotherapy with anti-CD19 chimeric antigen receptor (CAR) T cells has shown significant efficacy in B-cell malignancies, CAR T cells directed against CD30 (CAR30) for the treatment of Hodgkin lymphoma (HL) showed modest antitumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b438ab79f3ce7d5af44179dfcc76a63
https://doi.org/10.1182/blood-2020-139546

SUPRESSIVE EFFECT OF MESENCHYMAL STEM CELLS ON AIRWAY REMODELING IN VITRO

Autor: Ruben Osuna Gomez, Vicente Plaza Moral, Cristina Ujaldón Miró, Eder Fredy Mateus, David Ramos Barbón

Publikováno v: Allergy and immunology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17cc205949aca858d61fe5c599488fd8
https://doi.org/10.1183/13993003.congress-2018.pa1121