Enhancer engagement sustains oncogenic transformation and progression of B-cell precursor acute lymphoblastic leukemia

Autor: Giacomo Corleone, Cristina Sorino, Matteo Caforio, Stefano Di Giovenale, Francesca De Nicola, Frauke Goeman, Valentina Bertaina, Angela Pitisci, Clelia Cortile, Franco Locatelli, Valentina Folgiero, Maurizio Fanciulli

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-19 (2024)

Abstract Background Enhancer reprogramming plays a significant role in the heterogeneity of cancer. However, we have limited knowledge about the impact of chromatin remodeling in B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) patients, and h

Externí odkaz: https://doaj.org/article/e6a90fbd8fa04cd28df478d56fad768a

AATF/Che-1 RNA polymerase II binding protein overexpression reduces the anti-tumor NK-cell cytotoxicity through activating receptors modulation

Autor: Matteo Caforio, Nicola Tumino, Cristina Sorino, Isabella Manni, Stefano Di Giovenale, Giulia Piaggio, Simona Iezzi, Georgios Strimpakos, Elisabetta Mattei, Lorenzo Moretta, M. Fanciulli, Paola Vacca, Franco Locatelli, Valentina Folgiero

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionAATF/Che-1 over-expression in different tumors is well known and its effect on tumorigenicity is mainly due to its central role demonstrated in the oncogenic pathways of solid tumors, where it controls proliferation and viability. The eff

Externí odkaz: https://doaj.org/article/f5115f9bf1b74bdf9a69050d6bb081ea

GD2 redirected CAR T and activated NK-cell-mediated secretion of IFNγ overcomes MYCN-dependent IDO1 inhibition, contributing to neuroblastoma cell immune escape

Autor: Valentina Folgiero, Maurizio Fanciulli, Rita De Vito, Matteo Caforio, Cristina Sorino, Antonio Camera, Loredana Cifaldi, Alessia Vitale, Bianca Maria Goffredo, Doriana Fruci

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)

Immune escape mechanisms employed by neuroblastoma (NB) cells include secretion of immunosuppressive factors disrupting effective antitumor immunity. The use of cellular therapy to treat solid tumors needs to be implemented. Killing activity of anti-

Externí odkaz: https://doaj.org/article/de8a4cc4f673418187670c278aec1d15

CK2-mediated phosphorylation of Che-1/AATF is required for its pro-proliferative activity

Autor: Silvia Matteoni, Cristina Sorino, Tiziana Bruno, Valeria Catena, Maurizio Fanciulli, Gianluca Damonte, Simona Iezzi, Annalisa Salis

Publikováno v: Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-14 (2021)

Background Che-1/AATF (Che-1) is an RNA polymerase II binding protein involved in several cellular processes, including proliferation, apoptosis and response to stress. We have recently demonstrated that Che-1 is able to promote cell proliferation by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea659c20ebecc2c41c11f14fc0170220
https://doi.org/10.1186/s13046-021-02038-x

Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma

Autor: Enrico P. Spugnini, Katja Höpker, Mario Cioce, Luca Baldini, Bruno Amadio, Giacomo Corleone, Svitlana Gumenyuk, Giancarlo Cortese, Giovanni Blandino, Giovanni Cigliana, Simona Iezzi, Francesca De Nicola, Maurizio Fanciulli, Matteo Pallocca, Aristide Floridi, Francesco Pisani, Cristina Sorino, Maria Rosaria Ricciardi, Frauke Goeman, Tiziana Bruno, Bruno Vincenzi, Andrea Mengarelli, Elisabetta Mattei, Maria Teresa Petrucci, Umberto Gianelli, Thomas Benzing, Valeria Catena, Alfonso Baldi, Roberta Merola, Claudio Passananti, Gianluca Bossi

Publikováno v: Blood Adv
Blood advances 4 (2020): 5616–5630. doi:10.1182/bloodadvances.2020002566
info:cnr-pdr/source/autori:Tiziana Bruno 1, Francesca De Nicola 1, Giacomo Corleone 1, Valeria Catena 1, Frauke Goeman 1, Matteo Pallocca 1, Cristina Sorino 1, Gianluca Bossi 2, Bruno Amadio 1, Giovanni Cigliana 3, Maria Rosaria Ricciardi 4, Maria Teresa Petrucci 5, Enrico Pierluigi Spugnini 1, Alfonso Baldi 6, Mario Cioce 2, Giancarlo Cortese 1, Elisabetta Mattei 7, Roberta Merola 3, Umberto Gianelli 8, Luca Baldini 8, Francesco Pisani 9, Svitlana Gumenyuk 9, Andrea Mengarelli 9, Katja Höpker 10, Thomas Benzing 10 11 12, Bruno Vincenzi 13, Aristide Floridi 1, Claudio Passananti 14, Giovanni Blandino 2, Simona Iezzi 1, Maurizio Fanciulli 1/titolo:Che-1%2FAATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma/doi:10.1182%2Fbloodadvances.2020002566/rivista:Blood advances/anno:2020/pagina_da:5616/pagina_a:5630/intervallo_pagine:5616–5630/volume:4

Multiple myeloma (MM) is a hematologic malignancy produced by a clonal expansion of plasma cells and characterized by abnormal production and secretion of monoclonal antibodies. This pathology exhibits an enormous heterogeneity resulting not only fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1af284419cc671558000110b541c9b
http://hdl.handle.net/11591/438908