Protocol for a phase 3, randomised, active-control study of four-factor prothrombin complex concentrate versus frozen plasma in bleeding adult cardiac surgery patients requiring coagulation factor replacement: the LEX-211 (FARES-II) trial

Autor: Éric Dumont, Lusine Abrahamyan, Stuart Mccluskey, Angela Jerath, Humara Poonawala, Andrew Stevens, Jeannie Callum, Alan Tinmouth, Daniel Wong, Gianluigi Bisleri, Tarit Saha, David Mazer, Hilary Grocott, Jane Yang, Jeff Kinney, Yoan Lamarche, Damon Scales, George Tomlinson, Fuad Moussa, Andrew Shih, Michelle Zeller, Melanie Tokessy, Keyvan Karkouti, Vivek Rao, Summer Syed, Lilia Kaustov, Sophia Wong, Lani Lieberman, Kamrouz Ghadimi, Philippe Demers, Penny Johnson, Jerrold H Levy, Justyna Bartoszko, Miki Peer, Michael Law, Michelle Wong, Mackenzie Quantz, Antoine Rochon, Fraser Rubens, Shagun Jain, Yulia Lin, Katerina Pavenski, Deep Grewal, Deborah DuMerton, Darrin Payne, Saba Ansari, Robert Mayer, Rebecca Randall, Aftab Malik, Bethany Smethurst, Laura Molnar, Angela Sirosky-Yanyk, Mark Peterson, Christopher Harle, Etienne Couture, Diem Tran, Cristina Solomon, Sigurd Knaub, Kenichi A Tanaka, Blaine Achen, Sukhpal Brar, Matthew Coley, Dana Devine, Alana Flexman, Camila Machado de Souza, Maria Rosal Martins, Terri Sun, Rob Tanzola, Mathew Yan, Raffael Zamper, Jo Carrol, Nishanthi Liyanage, Simryn Selby, Reezanoor Kabir, Shelley Oliver, Alioska Escorcia, Susana Medic, Michelle Mozel, Ramanjot Kaur, Kelly Bizovie, Sarah Buchko, Raven Arly Gonzales, Korey Sutherland, Jenna Van Roekel, Alveena Babul, Ken Tanaka, Kofi Vandyck, Amir Butt, Hisako Okada, Robert Tanzola, Reegan Tod, Aiden Scholey, Wafaa Haider, Ester Cisneros-Aguilera, Alexandre Bergeron, Genevieve Belanger, Darren Mullane, Bevan Hughes, Sakara Hutspardol, Shirley Lim, Jian Mi, Debbie Kalar, Matthew Eang, Erick Lorenzana-Saldivar, Edward P Chen, Akash Gupta, Philip Lau, Pablo Perez D’Empaire, Chantal Armali, Amie Malkin, Connie Colavecchia, Harley Meirovich, Annie Bergeron, Francois Laforge, Kim Paradis, Nathalie Gagne, Marie Soleil Saillant, Marie-Claude Vézina, Olivier Royer, Marie-Ève Charest, Lee-Anne Fochesato, Yuxin Bai, Iqbal Jaffar, Nour Alhomsi, Janine Guevarra, Erin Jamula, Wan Chien (Betty) Hsu, Abbey Drew, Hakan Buyukdere, Drashtee Patel, Elizabeth Watt, Hadia Arabi Katbi, Kim Luciano, Amy Moorehead, Kamola Kasimova, Farzana Tasmin, Cielo Bingley, Victoria Barkley, Tob Reegan, Marianna Qu, Jessica Xiong, Sophie Robichaud, Christy Peterson, Manu Jairath, Mathew Tang, Jennita Aariaratnam, Leron DuMerton, Lucas Drew, Sahrish Masood, Toni Tidy, Elizabeth Krok

Publikováno v: BMJ Open, Vol 14, Iss 8 (2024)

Introduction Reduced thrombin generation is an important component of post cardiopulmonary bypass (CPB) coagulopathy. To replenish coagulation factors and enhance thrombin generation in bleeding surgical patients, frozen plasma (FP) and four-factor p

Externí odkaz: https://doaj.org/article/f4b23ce7268143bca04256dccb1c3cbf

Thromboelastometry profile in critically ill patients: A single-center, retrospective, observational study.

Autor: Tomaz Crochemore, Thiago Domingos Corrêa, Marcus D Lance, Cristina Solomon, Ary Serpa Neto, João Carlos de Campos Guerra, Priscila Scolmeister Lellis, Livia Muller Bernz, Natalia Nunes, Cassio Massashi Mancio, Ana Paula Hitomi Yokoyama, Eliézer Silva

Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0192965 (2018)

Transfusion therapy is associated with increased morbidity, mortality and costs. Conventional coagulation tests (CCT) are weak bleeding predictors, poorly reflecting coagulation in vivo. Thromboelastometry (ROTEM) provides early identification of coa

Externí odkaz: https://doaj.org/article/c34affb956a24f6b88f6a77334f745b7

Efficacy and safety of fibrinogen concentrate for perioperative prophylaxis of bleeding in adult, adolescent, and pediatric patients with congenital fibrinogen deficiency: FORMA ‐02 and FORMA ‐04 clinical trials

Autor: Claudia Djambas Khayat, Sunil Lohade, Omid Reza Zekavat, Irina Kruzhkova, Cristina Solomon, Flora Peyvandi

Publikováno v: Transfusion. 62:1871-1881

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b21b60c0fa6c05929195156b78d13a65
https://doi.org/10.1111/trf.17029

Atenativ, a Plasma-Derived Antithrombin Concentrate, Used in Patients with Congenital Antithrombin Deficiency Undergoing Surgery or Parturition: Study Description (NCT04918173)

Autor: Craig M. Kessler, Claudio Sandoval, Martina Jansen, Cristina Solomon, Sigurd Knaub, Michael D Tarantino

Publikováno v: Blood. 140:8548-8549

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fd2de0465286a4d59b5814241bc3bfb
https://doi.org/10.1182/blood-2022-166246

Human Fibrinogen Concentrate for Bleeding Prophylaxis During Surgery in Paediatric Patients with Congenital Fibrinogen Deficiency

Autor: Omid Reza Zekavat, FD Souza, LS Gowda, C. Djambas Khayat, Bruce A. Schwartz, SD Lohade, Flora Peyvandi, Irina Kruzhkova, Cristina Solomon

Publikováno v: 65th Annual Meeting of the Society of Thrombosis and Haemostasis Research.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::accd77ef18f222009647c4e4c8fa9ad0
https://doi.org/10.1055/s-0041-1728118