Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Cristina Sisu"'
Autor:
Denise Ragusa, Ylenia Cicirò, Concetta Federico, Salvatore Saccone, Francesca Bruno, Reza Saeedi, Cristina Sisu, Cristina Pina, Arturo Sala, Sabrina Tosi
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-7 (2022)
Abstract Acute myeloid leukaemia carrying the translocation t(7;12)(q36;p13) is an adverse-risk leukaemia uniquely observed in infants. Despite constituting up to 30% of cases in under 2-year-olds, it remains poorly understood. Known molecular featur
Externí odkaz:
https://doaj.org/article/5e65c05896734882813936b8b25d5ac4
Autor:
Rachel Kerslake, Birhanu Belay, Suzana Panfilov, Marcia Hall, Ioannis Kyrou, Harpal S. Randeva, Jari Hyttinen, Emmanouil Karteris, Cristina Sisu
Publikováno v:
Cancers, Vol 15, Iss 13, p 3350 (2023)
Three-dimensional (3D) cancer models are revolutionising research, allowing for the recapitulation of an in vivo-like response through the use of an in vitro system, which is more complex and physiologically relevant than traditional monolayer cultur
Externí odkaz:
https://doaj.org/article/ffc8e1958a6d43e19f893fd259cef6fe
Autor:
Cristina Sisu, Paul Muir, Adam Frankish, Ian Fiddes, Mark Diekhans, David Thybert, Duncan T. Odom, Paul Flicek, Thomas M. Keane, Tim Hubbard, Jennifer Harrow, Mark Gerstein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Pseudogenes are key markers of genome remodelling processes. Here the authors present genome-wide annotation of the pseudogenes in the mouse reference genome and 18 inbred mouse strains, update human pseudogene annotations, and characterise the trans
Externí odkaz:
https://doaj.org/article/bc3bf2d1f24949899d576df8a558a91e
Publikováno v:
Cells, Vol 11, Iss 22, p 3577 (2022)
The identification of diagnostic and prognostic biomarkers is a major objective in improving clinical outcomes in cancer, which has been facilitated by the availability of high-throughput gene expression data. A growing interest in non-coding genomic
Externí odkaz:
https://doaj.org/article/36c23c3945a24da08394a4bac8d9be64
Autor:
Rachel Kerslake, Cristina Sisu, Suzana Panfilov, Marcia Hall, Nabeel Khan, Jeyarooban Jeyaneethi, Harpal Randeva, Ioannis Kyrou, Emmanouil Karteris
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 19, p 5942 (2022)
Background: Ovarian cancer (OvCa) is one of the most lethal forms of gynaecological malignancy. Altered energy metabolism and increased aerobic glycolysis in OvCa are hallmarks that demand attention. The glucogenic hormone asprosin is often dysregula
Externí odkaz:
https://doaj.org/article/4f53fb2fa3994969b6f2024f6df8c5d3
Autor:
Aeman Zahra, Rachel Kerslake, Ioannis Kyrou, Harpal S. Randeva, Cristina Sisu, Emmanouil Karteris
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5334 (2022)
Endocrine-disrupting chemicals (EDCs), including the xenoestrogen Bisphenol A (BPA), can interfere with hormonal signalling. Despite increasing reports of adverse health effects associated with exposure to EDCs, there are limited data on the effect o
Externí odkaz:
https://doaj.org/article/869d847100854a7ea44faa0107746249
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1725 (2022)
Background: Recently, we have shown that seven genes, namely GBP5, IRS2, KRT4, LINCOO707, MRPL55, RRS1 and SLC4A11, have prognostic power for the overall survival in ovarian cancer (OC). Methods: We present an analysis on the association of these gen
Externí odkaz:
https://doaj.org/article/b3e8acd3539a45bd99fd5aaeb3725a52
Autor:
Alice Filipe, Periklis Katopodis, Dimple Chudasama, Rachel Kerslake, Jeyarooban Jeyaneethi, Vladimir Anikin, Elisabete Silva, Ioannis Kyrou, Harpal S. Randeva, Cristina Sisu, Marcia Hall, Emmanouil Karteris
Publikováno v:
Journal of Personalized Medicine, Vol 12, Iss 2, p 201 (2022)
Background: DNA double strand breaks can affect genome integrity potentially leading to cancer. RAD51-associated protein 1 (RAD51AP1), an accessory protein to RAD51, is critical for homologous recombination, a key DNA damage response pathway. Emergin
Externí odkaz:
https://doaj.org/article/8e3e52cf903f4dbc8d01e191510f7857
Autor:
Aeman Zahra, Qiduo Dong, Marcia Hall, Jeyarooban Jeyaneethi, Elisabete Silva, Emmanouil Karteris, Cristina Sisu
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 9, p 1979 (2021)
Endocrine-disrupting chemicals (EDCs) can exert multiple deleterious effects and have been implicated in carcinogenesis. The xenoestrogen Bisphenol A (BPA) that is found in various consumer products has been involved in the dysregulation of numerous
Externí odkaz:
https://doaj.org/article/3e66c206635e404c9fd578701b998cfb
Autor:
Periklis Katopodis, Qiduo Dong, Heerni Halai, Cristian I. Fratila, Andreas Polychronis, Vladimir Anikin, Cristina Sisu, Emmanouil Karteris
Publikováno v:
Cancers, Vol 12, Iss 12, p 3499 (2020)
Long non-coding RNAs (lncRNAs) perform a wide functional repertoire of roles in cell biology, ranging from RNA editing to gene regulation, as well as tumour genesis and tumour progression. The lncRNA X-inactive specific transcript (XIST) is involved
Externí odkaz:
https://doaj.org/article/704f0fa8d04a4a68bb72ed1e8b71ed62