Výsledky vyhledávání - "Cristina Sampedro"

Akademický článek

A Protein Misfolding Shaking Amplification-based method for the spontaneous generation of hundreds of bona fide prions

Autor: Hasier Eraña, Cristina Sampedro-Torres-Quevedo, Jorge M. Charco, Carlos M. Díaz-Domínguez, Francesca Peccati, Maitena San-Juan-Ansoleaga, Enric Vidal, Nuno Gonçalves-Anjo, Miguel A. Pérez-Castro, Ezequiel González-Miranda, Patricia Piñeiro, Leire Fernández-Veiga, Josu Galarza-Ahumada, Eva Fernández-Muñoz, Guiomar Perez de Nanclares, Glenn Telling, Mariví Geijo, Gonzalo Jiménez-Osés, Joaquín Castilla

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Prion diseases are a group of rapidly progressing neurodegenerative disorders caused by the misfolding of the endogenous prion protein (PrPC) into a pathogenic form (PrPSc). This process, despite being the central event underlying these diso

Externí odkaz: https://doaj.org/article/a04d98f58ccd4cb2b901a29e2c563eae

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Akademický článek

Understanding the key features of the spontaneous formation of bona fide prions through a novel methodology that enables their swift and consistent generation

Publikováno v: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-30 (2023)

Abstract Among transmissible spongiform encephalopathies or prion diseases affecting humans, sporadic forms such as sporadic Creutzfeldt–Jakob disease are the vast majority. Unlike genetic or acquired forms of the disease, these idiopathic forms oc

Externí odkaz: https://doaj.org/article/63c13fcaea6249e3a04b3b8cea76b3ad

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Akademický článek

Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans

Autor: María Eugenia Goya, Feng Xue, Cristina Sampedro-Torres-Quevedo, Sofia Arnaouteli, Lourdes Riquelme-Dominguez, Andrés Romanowski, Jack Brydon, Kathryn L. Ball, Nicola R. Stanley-Wall, Maria Doitsidou

Publikováno v: Cell Reports, Vol 30, Iss 2, Pp 367-380.e7 (2020)

Summary: Recent discoveries have implicated the gut microbiome in the progression and severity of Parkinson’s disease; however, how gut bacteria affect such neurodegenerative disorders remains unclear. Here, we report that the Bacillus subtilis pro

Externí odkaz: https://doaj.org/article/a87257da5bfb470a9a0549aa4440b32f

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Akademický článek

Design of Potential Antimalarial Agents Based on a Homology Model of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase

Autor: Caterina Pont, Nelson Alencar, Irene Sola, María Linares, Luca Di Palma, Carla Barbaraci, Cristina Sampedro, Jordi Juárez-Jiménez, Paloma Abad, Susana Pérez-Benavente, Jerónimo Lameira, José M. Bautista, F. Javier Luque, Diego Muñoz-Torrero

Publikováno v: Proceedings, Vol 1, Iss 6, p 665 (2017)

There currently exists a dire need for safe and inexpensive new antimalarial drugs, which are effective against multiple life cycle stages of Plasmodium falciparum, and act through mechanisms that differ from those of the available drugs to prevent d

Externí odkaz: https://doaj.org/article/f7924fcb0904490f8c4115706b902d34

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Akademický článek

Paisajes agrarios prehistóricos en la Meseta Peninsular: el caso de «Las Matillas» (Alcalá de Henares, Madrid)

Autor: Pedro Díaz-Del-Río, Susana Consuegra, Leonor Peña Chocarro, Belén Márquez, Cristina Sampedro, Ruth Moreno, Daniele Albertini, Beatriz Pino

Publikováno v: Trabajos de Prehistoria, Vol 54, Iss 2, Pp 93-111 (1997)

Presentamos los resultados de un proyecto interdisciplinar diseñado para las condiciones efímeras de una intervención de urgencia. La excavación de una formación arqueológica característica de la Prehistoria reciente de la Meseta peninsular, e

Externí odkaz: https://doaj.org/article/092c8e89de33407ba8baae13c17b1561

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Laboratory Identification of Prion Infections

Autor: Miguel A. Pérez-Castro, Juan Tasis-Galarza, Joaquín Castilla, Cristina Sampedro-Torres-Quevedo, Jorge M. Charco, Leire Fernández-Veiga, Carlos M. Díaz-Domínguez, Izaro Kortazar-Zubizarreta, Hasier Eraña

Publikováno v: Encyclopedia of Infection and Immunity ISBN: 9780323903035
Reference Module in Biomedical Sciences

Transmissible spongiform encephalopathies (TSE) or prion diseases are a group of rapidly progressing neurodegenerative diseases caused by uncommon pathogens, devoid of nucleic acids that affect several mammals including humans. These proteinaceous in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0109b73d5964b85cdbc5b48a4c1116
https://zenodo.org/record/5534101

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First homology model of Plasmodium falciparum glucose-6-phosphate dehydrogenase: Discovery of selective substrate analog-based inhibitors as novel antimalarial agents

Autor: F. Javier Luque, Cristina Sampedro, José M. Bautista, Antonio Viayna, Nelson Alencar, Jerônimo Lameira, Jordi Juárez-Jiménez, Diego Muñoz-Torrero, Caterina Pont, Irene Sola, Paloma Abad, David Vilchez, María Linares, Susana Pérez-Benavente

Publikováno v: European Journal of Medicinal Chemistry. 146:108-122

In Plasmodium falciparum the bifunctional enzyme glucose-6-phosphate dehydrogenase‒6-phosphogluconolactonase (PfG6PD‒6PGL) is involved in the catalysis of the first reaction of the pentose phosphate pathway. Since this enzyme has a key role in pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4149283f372b5293db5d9b1ed9d0808c
https://doi.org/10.1016/j.ejmech.2018.01.044

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Design of Potential Antimalarial Agents Based on a Homology Model of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase

Autor: Luca Di Palma, Caterina Pont, Nelson Alberto N. de Alencar, F. Javier Luque, Susana Pérez-Benavente, Jerônimo Lameira, José M. Bautista, María Linares, Cristina Sampedro, Paloma Abad, Irene Sola, Diego Muñoz-Torrero, Carla Barbaraci, Jordi Juárez-Jiménez

Publikováno v: Proceedings, Vol 1, Iss 6, p 665 (2017)
E-Prints Complutense. Archivo Institucional de la UCM
instname
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d093cba95a1e6b58a5c95eb245dd6141
https://www.mdpi.com/2504-3900/1/6/665

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Paisajes agrarios prehistóricos en la Meseta Peninsular: el caso de «Las Matillas» (Alcalá de Henares, Madrid)

Autor: Daniele Albertini, Belén Márquez, Beatriz Pino, Ruth Moreno, Cristina Sampedro, Susana Consuegra, Leonor Peña Chocarro, Pedro Díaz-del-Río

Publikováno v: Trabajos de Prehistoria, Vol 54, Iss 2, Pp 93-111 (1997)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Trabajos de Prehistoria; Vol 54, No 2 (1997); 93-111

[ES] Presentamos los resultados de un proyecto interdisciplinar diseñado para las condiciones efímeras de una intervención de urgencia. La excavación de una formación arqueológica característica de la Prehistoria reciente de la Meseta peninsul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71eeb6010fba9db5bb80e9e838beff0
http://tp.revistas.csic.es/index.php/tp/article/view/368/372

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