Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Cristina S J Rocha"'
Autor:
Helen Bergquist, Cristina S J Rocha, Rubén Álvarez-Asencio, Chi-Hung Nguyen, Mark W Rutland, C I Edvard Smith, Liam Good, Peter E Nielsen, Rula Zain
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0165788 (2016)
Expansion of (GAA)n repeats in the first intron of the Frataxin gene is associated with reduced mRNA and protein levels and the development of Friedreich's ataxia. (GAA)n expansions form non-canonical structures, including intramolecular triplex (H-D
Externí odkaz:
https://doaj.org/article/31f002a6d0df4a0a874c8cb555cdc41c
Autor:
Yoshitsugu Aoki, Cristina S. J. Rocha, Taavi Lehto, Shouta Miyatake, Henrik Johansson, Yasumasa Hashimoto, Joel Z. Nordin, Imre Mager, Misako Aoki, McClorey Graham, Chaitra Sathyaprakash, Thomas C. Roberts, Matthew J. A. Wood, Mark A. Behlke, Samir El Andaloussi
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Splice-switching antisense oligonucleotide- (SSO-) mediated correction of framedisrupting mutation-containing premessenger RNA (mRNA) transcripts using exon skipping is a highly promising treatment method for muscular diseases such as Duchenne muscul
Externí odkaz:
https://doaj.org/article/0ea4440e5f7542ee82645e95690437a3
Autor:
Catarina Nilsson, Rosanne M. Crooke, Nigel Davies, Birgitta Rosengren, Brett P. Monia, Eva Hurt-Camejo, Cristina S. J. Rocha, Tina Rydén-Bergsten, Stan Riney, Daniel Lindén, Rosie Z. Yu, Yanfeng Wang, Peter Gennemark, Anna Tivesten, Dorota Kakol-Palm, Ulf Andersson, Lloyd G. Tillman, Marie Elebring, Björn Carlsson, Mikko Hölttä, Jane Knöchel, Linda Wernevik, Rasmus Jansson-Löfmark, Niclas Clemmensen, Rikard Isaksson, Katrin Walter, Richard S. Geary, Dinko Rekić
Publikováno v:
Science Translational Medicine. 13
Inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9) reduce low-density lipoprotein (LDL) cholesterol and are used for treatment of dyslipidemia. Current PCSK9 inhibitors are administered via subcutaneous injection. We present a highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197948bccc867454748627a58e0b6234
https://doi.org/10.1126/scitranslmed.abe9117
https://doi.org/10.1126/scitranslmed.abe9117
Autor:
Yanfeng Wang, Anna Tivesten, Niclas Clemmensen, Dinko Rekić, Mikko Hölttä, Marie Elebring, Lloyd G. Tillman, Catarina Nilsson, Björn Carlsson, stanley riney, Rosie Z. Yu, Kristina Ryden-Bergsten, Brett P. Monia, Rosanne M. Crooke, Daniel Lindén, Jane Knoechel, Katrin Walter, Eva Hurt-Camejo, Rasmus Jansson-Löfmark, Cristina S. J. Rocha, Peter Gennemark, Ulf Andersson, Nigel Davies
Publikováno v:
Circulation. 142
Current PCSK9 inhibitors are administered via subcutaneous (SC) injection. Here, we present a highly potent, chemically modified PCSK9 antisense oligonucleotide (ASO) with potential for oral delivery. Past attempts at oral delivery using earlier ASO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9933060a0f89627c4a1483b9e72cb980
https://doi.org/10.1161/circ.142.suppl_3.13307
https://doi.org/10.1161/circ.142.suppl_3.13307
Autor:
Cristina S J, Rocha
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2036
Today, there are emerging numbers of oligonucleotide therapies being approved by the governmental authorities. These types of therapies present a different mode of action when compared to the traditional small molecules, acting at the RNA level inste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47a57602903766b6282d3f9ea98ad5d3
https://pubmed.ncbi.nlm.nih.gov/31410791
https://pubmed.ncbi.nlm.nih.gov/31410791
Autor:
Cristina S. J. Rocha
Publikováno v:
Methods in Molecular Biology ISBN: 9781493996698
Today, there are emerging numbers of oligonucleotide therapies being approved by the governmental authorities. These types of therapies present a different mode of action when compared to the traditional small molecules, acting at the RNA level inste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da2810f23f888e7f7517baba74de9539
https://doi.org/10.1007/978-1-4939-9670-4_4
https://doi.org/10.1007/978-1-4939-9670-4_4
Autor:
Cristina S. J. Rocha, Oscar P. B. Wiklander, Pedro Moreno, C. I. Edvard Smith, Lilian Larsson, Karin E. Lundin, Paolo Parini
Publikováno v:
Journal of Molecular and Cellular Cardiology. 82:186-193
Hypercholesterolemia is a medical condition often characterized by high levels of low-density lipoprotein cholesterol (LDL-C) in the blood. Despite the available therapies, not all patients show sufficient responses, especially those with very high l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90796cb84e46de90530f175400d55deb
Autor:
Cristina S. J. Rocha, Stefan Milton, Dmytro Honcharenko, Roger Strömberg, Pedro Moreno, C. I. Edvard Smith
Publikováno v:
Chemical Communications. 51:4044-4047
2'-O-AECM modified oligonucleotides provide an unusual combination of remarkable properties. This includes the combination of high resistance towards enzymatic degradation and the spontaneous cellular uptake of AECM oligonucleotides.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db661339ebec70f2360e3e9a7e799f1a
https://doi.org/10.1039/c4cc08837a
https://doi.org/10.1039/c4cc08837a
Autor:
Y. Vladimir Pabon, Burcu Bestas, Sylvain Geny, Samir El Andaloussi, Rula Zain, C. I. Edvard Smith, Per T. Jørgensen, Jesper Wengel, Eman M. Zaghloul, Cristina S. J. Rocha, Helen Bergquist, Iulian I. Oprea, Erik B. Pedersen, Pedro Moreno, Karin E. Lundin
Publikováno v:
Moreno, P M D, Geny, S, Pabon, Y V, Bergquist, H, Zaghloul, E M, Rocha, C S J, Oprea, I I, Bestas, B, Andaloussi, S E, Jørgensen, P T, Pedersen, E B, Lundin, K E, Zain, R, Wengel, J & Smith, C I E 2013, ' Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA ', Nucleic Acids Research, vol. 41, no. 5, pp. 3257-3273 . https://doi.org/10.1093/nar/gkt007
Nucleic Acids Research
Nucleic Acids Research; Vol 41
Nucleic Acids Research
Nucleic Acids Research; Vol 41
In spite of the many developments in synthetic oligonucleotide (ON) chemistry and design, invasion into double-stranded DNA (DSI) under physiological salt and pH conditions remains a challenge. In this work, we provide a new ON tool based on locked n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33c536d31a11df21278a74d1e527aa4
https://doi.org/10.1093/nar/gkt007
https://doi.org/10.1093/nar/gkt007
Autor:
Mark W. Rutland, Helen Bergquist, Cristina S. J. Rocha, C. I. Edvard Smith, Peter E. Nielsen, Chi-Hung Nguyen, Rubén Álvarez-Asencio, Liam Good, Rula Zain
Publikováno v:
PLoS One
Bergquist, H, Rocha, C S J, Alvarez-Asencio, R, Chi-Hung Nguyen, Rutland, M W, Smith, C I E, Good, L, Nielsen, P E & Zain, R 2016, ' Disruption of Higher Order DNA Structures in Friedreich's Ataxia (GAA)(n) Repeats by PNA or LNA Targeting ', P L o S One, vol. 11, no. 11, e0165788 . https://doi.org/10.1371/journal.pone.0165788
Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
instname
PLoS ONE, Vol 11, Iss 11, p e0165788 (2016)
PLoS ONE
Bergquist, H, Rocha, C S J, Alvarez-Asencio, R, Chi-Hung Nguyen, Rutland, M W, Smith, C I E, Good, L, Nielsen, P E & Zain, R 2016, ' Disruption of Higher Order DNA Structures in Friedreich's Ataxia (GAA)(n) Repeats by PNA or LNA Targeting ', P L o S One, vol. 11, no. 11, e0165788 . https://doi.org/10.1371/journal.pone.0165788
Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
instname
PLoS ONE, Vol 11, Iss 11, p e0165788 (2016)
PLoS ONE
Expansion of (GAA)(n) repeats in the first intron of the Frataxin gene is associated with reduced mRNA and protein levels and the development of Friedreich's ataxia. (GAA)(n) expansions form non-canonical structures, including intramolecular triplex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116779149fe0c756b689293ed9276dbb
http://hdl.handle.net/20.500.12614/379
http://hdl.handle.net/20.500.12614/379