Glutamate neurotransmission from leptin receptor cells is required for typical puberty and reproductive function in female mice

Autor: Cristina Sáenz de Miera, Nicole Bellefontaine, Susan J Allen, Martin G Myers, Carol F Elias

Publikováno v: eLife, Vol 13 (2024)

The hypothalamic ventral premammillary nucleus (PMv) is a glutamatergic nucleus essential for the metabolic control of reproduction. However, conditional deletion of leptin receptor long form (LepRb) in vesicular glutamate transporter 2 (Vglut2) expr

Externí odkaz: https://doaj.org/article/814f8f7c34ea4f118394c7ffcd2b5a69

An Intact Krüppel-like factor 9 Gene Is Required for Acute Liver Period 1 mRNA Response to Restraint Stress

Autor: Robert J. Denver, Joseph R. Knoedler, Cristina Sáenz de Miera, Arasakumar Subramani

Publikováno v: Endocrinology

The clock protein period 1 (PER1) is a central component of the core transcription-translation feedback loop governing cell-autonomous circadian rhythms in animals. Transcription of Per1 is directly regulated by the glucocorticoid (GC) receptor (GR),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6943ab155d17e11dd3022433a2b9169f
https://doi.org/10.1210/endocr/bqab083

Modulation of hypothalamic S6K1 and S6K2 alters feeding behavior and systemic glucose metabolism

Autor: Isadora Carolina Betim Pavan, Fernando Moreira Simabuco, Cristina Sáenz de Miera, Marcio Alberto Torsoni, Mariana Rosolen Tavares, Thaís de Fante, Carol F. Elias, Rosangela Maria Neves Bezerra, Simone Ferreira Lemes, Patrícia O. Prada

Publikováno v: J Endocrinol

The mTOR/S6Ks signaling is one of the intracellular pathways important for metabolic control, acting both peripherally and centrally. In the hypothalamus, mTOR/S6Ks axis mediates the action of leptin and insulin and can modulate the expression of neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c12187fefe9d5b691a366d2ff67e582
https://europepmc.org/articles/PMC8010582/

An integrative view of mammalian seasonal neuroendocrinology

Autor: Cristina Sáenz de Miera, Francis J. P. Ebling, Shona H. Wood, Hugues Dardente

Publikováno v: Journal of Neuroendocrinology
9th International Congress of Neuroendocrinology
9th International Congress of Neuroendocrinology, Jul 2018, Toronto, Canada. pp.17, ⟨10.1111/jne.12729⟩

This is the peer reviewed version of the following article: Dardente, H., Wood, S.H., Ebling, F. & Sáenz de Miera, C. (2019). An integrative view of mammalian seasonal neuroendocrinology. Journal of neuroendocrinology. Journal of Neuroendocrinology,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1984ea714923fdadae8dca08848d530f
https://hal.inrae.fr/hal-02738063

Maternal photoperiod programs hypothalamic thyroid status via the fetal pituitary gland

Autor: David G. Hazlerigg, Catherine Jaeger, Béatrice Bothorel, Cristina Sáenz de Miera, Valérie Simonneaux

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (31), pp.8408-8413. ⟨10.1073/pnas.1702943114⟩

In wild mammals, offspring development must anticipate forthcoming metabolic demands and opportunities. Within species, different developmental strategies may be used, dependent on when in the year conception takes place. This phenotypic flexibility

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2fbfceb43b6f3507cbd874e4170cd16
https://hal.archives-ouvertes.fr/hal-02390103