Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Cristina Ramondetti"'
Autor:
Stefano Sainas, Marta Giorgis, Paola Circosta, Giulio Poli, Marta Alberti, Alice Passoni, Valentina Gaidano, Agnese C. Pippione, Nicoletta Vitale, Davide Bonanni, Barbara Rolando, Alessandro Cignetti, Cristina Ramondetti, Alessia Lanno, Davide M. Ferraris, Barbara Canepa, Barbara Buccinnà, Marco Piccinini, Menico Rizzi, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Riccardo Miggiano, Tiziano Tuccinardi, Marco L. Lolli
Publikováno v:
Journal of Medicinal Chemistry. 65:12701-12724
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e61aeadeb5c771296d71bc58f9453a
https://doi.org/10.1021/acs.jmedchem.2c00496
https://doi.org/10.1021/acs.jmedchem.2c00496
Autor:
Stefano, Sainas, Marta, Giorgis, Paola, Circosta, Giulio, Poli, Marta, Alberti, Alice, Passoni, Valentina, Gaidano, Agnese C, Pippione, Nicoletta, Vitale, Davide, Bonanni, Barbara, Rolando, Alessandro, Cignetti, Cristina, Ramondetti, Alessia, Lanno, Davide M, Ferraris, Barbara, Canepa, Barbara, Buccinnà, Marco, Piccinini, Menico, Rizzi, Giuseppe, Saglio, Salam, Al-Karadaghi, Donatella, Boschi, Riccardo, Miggiano, Tiziano, Tuccinardi, Marco L, Lolli
Publikováno v:
Journal of medicinal chemistry. 65(19)
In recent years, human dihydroorotate dehydrogenase inhibitors have been associated with acute myelogenous leukemia as well as studied as potent host targeting antivirals. Starting from MEDS433 (IC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6dcbf865bb1c31de62ba0891a7377431
https://pubmed.ncbi.nlm.nih.gov/36162075
https://pubmed.ncbi.nlm.nih.gov/36162075
Publikováno v:
Biochemical pharmacology. 204
Lapatinib is a highly selective reversible inhibitor of the tyrosine kinase domains of HER2 and EGFR, approved for the treatment of advanced stage HER2-overexpressing breast cancers. Although targeted therapy with lapatinib provides initial clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8bfd3f808cf1445492719b676075c06
https://pubmed.ncbi.nlm.nih.gov/36007575
https://pubmed.ncbi.nlm.nih.gov/36007575
Autor:
Marta Giorgis, Donatella Boschi, Barbara Buccinnà, Stefano Sainas, Mariia Mishina, Davide Bonanni, Alice Passoni, Salam Al-Karadaghi, Yaqi Qiu, Cristina Ramondetti, Paola Circosta, Giuseppe Saglio, Marco Piccinini, Valentina Gaidano, Mohammad Houshmand, Alessandro Bona, Alessandro Cignetti, Enrico Giraudo, Carina Florina Cojocaru, Marco Lucio Lolli, Barbara Rolando, Renzo Bagnati, Agnese Chiara Pippione, Barbara Canepa
Publikováno v:
Journal of Medicinal Chemistry. 64:5404-5428
The connection with acute myelogenous leukemia (AML) of dihydroorotate dehydrogenase (hDHODH), a key enzyme in pyrimidine biosynthesis, has attracted significant interest from pharma as a possible AML therapeutic target. We recently discovered compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281c81addc6474b683c17e342be6dc2c
https://doi.org/10.1021/acs.jmedchem.0c01549
https://doi.org/10.1021/acs.jmedchem.0c01549
Autor:
Stefano, Sainas, Marta, Giorgis, Paola, Circosta, Valentina, Gaidano, Davide, Bonanni, Agnese C, Pippione, Renzo, Bagnati, Alice, Passoni, Yaqi, Qiu, Carina Florina, Cojocaru, Barbara, Canepa, Alessandro, Bona, Barbara, Rolando, Mariia, Mishina, Cristina, Ramondetti, Barbara, Buccinnà, Marco, Piccinini, Mohammad, Houshmand, Alessandro, Cignetti, Enrico, Giraudo, Salam, Al-Karadaghi, Donatella, Boschi, Giuseppe, Saglio, Marco L, Lolli
Publikováno v:
Journal of Medicinal Chemistry
The connection with acute myelogenous leukemia (AML) of dihydroorotate dehydrogenase (hDHODH), a key enzyme in pyrimidine biosynthesis, has attracted significant interest from pharma as a possible AML therapeutic target. We recently discovered compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::95d65008168d44ed9e2830b4469d53dd
https://pubmed.ncbi.nlm.nih.gov/33844533
https://pubmed.ncbi.nlm.nih.gov/33844533
Autor:
Parveen Goyal, Salam Al-Karadaghi, Rodolpho C. Braga, Carolina Horta Andrade, Marco Lucio Lolli, Stefano Sainas, Cristina Ramondetti, Ann Christin Moritzer, Stefano Mensa, Rosmarie Friemann, Elisa Lupino, Marco Piccinini, Agnese Chiara Pippione, Marta Giorgis, Mikael Andersson, Donatella Boschi, Barbara Buccinnà
Publikováno v:
European Journal of Medicinal Chemistry. 129:287-302
A new generation of potent hDHODH inhibitors designed by a scaffold-hopping replacement of the quinolinecarboxylate moiety of brequinar, one of the most potent known hDHODH inhibitors, is presented here. Their general structure is characterized by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98383820cbc5a04a1459d2702625af04
https://doi.org/10.1016/j.ejmech.2017.02.017
https://doi.org/10.1016/j.ejmech.2017.02.017
Autor:
Rosmarie Friemann, Marco Piccinini, Giuseppe Saglio, Davide Bonanni, Stefano Sainas, Salam Al-Karadaghi, Parveen Goyal, Marco Lucio Lolli, Mikael Andersson, Marta Giorgis, Alessandro Cignetti, Alex Ducime, Michael Järvå, Elisa Lupino, Valentina Gaidano, Paola Circosta, Cristina Ramondetti, Donatella Boschi, Barbara Buccinnà, Agnese Chiara Pippione, Barbara Rolando
Publikováno v:
Journal of medicinal chemistry. 61(14)
Human dihydroorotate dehydrogenase ( hDHODH) catalyzes the rate-limiting step in de novo pyrimidine biosynthesis, the conversion of dihydroorotate to orotate. hDHODH has recently been found to be associated with acute myelogenous leukemia, a disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3565aec1c31af186bfb5671286cf52e5
https://pubmed.ncbi.nlm.nih.gov/30694669
https://pubmed.ncbi.nlm.nih.gov/30694669
Publikováno v:
Biochemical Pharmacology. 92:235-250
Imatinib mesylate is a tyrosine kinase inhibitor with selectivity for abelson tyrosine-protein kinase 1 (c-Abl), breakpoint cluster region (Bcr)-Abl fusion protein (Bcr-Abl), mast/stem cell growth factor receptor Kit (c-Kit), and platelet-derived gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de682fd4b51388c08f7d0d331d0ced17
https://doi.org/10.1016/j.bcp.2014.09.016
https://doi.org/10.1016/j.bcp.2014.09.016
Autor:
Stefano Sainas, Agnese C. Pippione, Elisa Lupino, Marta Giorgis, Paola Circosta, Valentina Gaidano, Parveen Goyal, Davide Bonanni, Barbara Rolando, Alessandro Cignetti, Alex Ducime, Mikael Andersson, Michael Järvå, Rosmarie Friemann, Marco Piccinini, Cristina Ramondetti, Barbara Buccinnà, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco L. Lolli
Publikováno v:
Journal of Medicinal Chemistry. 62:1696-1696
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149b56909a6d3a5b2d58d781ea12ceda
https://doi.org/10.1021/acs.jmedchem.9b00057
https://doi.org/10.1021/acs.jmedchem.9b00057
Autor:
Paolo Tosco, Loretta Lazzarato, Alberto Gasco, Clara Cena, Elisa Lupino, Cristina Ramondetti, Elisabetta Marini, Roberta Fruttero, Marco Piccinini
Publikováno v:
ChemMedChem. 6:523-530
A recently described series of nitrooxyacyl derivatives of salicylic acid, displaying aspirin-like anti-inflammatory and platelet anti-aggregatory properties, were evaluated for their abilities to inhibit cyclooxygenase (COX). A number of these compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e6aa4d8d66c2ea685af12eb9549a44
https://doi.org/10.1002/cmdc.201000397
https://doi.org/10.1002/cmdc.201000397