Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Cristina Perpiñá"'
Publikováno v:
ACS Pharmacology & Translational Science
The CXCL12 chemokine receptor CXCR4 belongs to the GPCR superfamily and is often overexpressed in cancer, being involved in tumor progression and metastasis. How CXCR4 signaling integrates with other relevant oncogenic transduction pathways and the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d46ef34b760c3b5d91e9dff92ba7e1
http://europepmc.org/articles/PMC7553016
http://europepmc.org/articles/PMC7553016
Autor:
Asuka Inoue, Paolo Annibale, Carsten Hoffmann, Cristina Perpiñá-Viciano, Jan Möller, Raimond Heukers, Chris de Graaf, Vladimir Bobkov, Martin J. Lohse, Martine J. Smit, Marta Arimont, Ali Işbilir
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 117(46), 29144-29154. National Acad Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proc Natl Acad Sci U S A.
Işbilir, A, Möller, J, Arimont, M, Bobkov, V, Perpiñá-Viciano, C, Hoffmann, C, Inoue, A, Heukers, R, de Graaf, C, Smit, M J, Annibale, P & Lohse, M J 2020, ' Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 46, pp. 29144-29154 . https://doi.org/10.1073/pnas.2013319117
Proceedings of the National Academy of Sciences of the United States of America
Proc Natl Acad Sci U S A.
Işbilir, A, Möller, J, Arimont, M, Bobkov, V, Perpiñá-Viciano, C, Hoffmann, C, Inoue, A, Heukers, R, de Graaf, C, Smit, M J, Annibale, P & Lohse, M J 2020, ' Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 46, pp. 29144-29154 . https://doi.org/10.1073/pnas.2013319117
Significance Class A G protein−coupled receptors (GPCRs) can form dimers and oligomers via poorly understood mechanisms. We show here that the chemokine receptor CXCR4, which is a major pharmacological target, has an oligomerization behavior modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51bf326bb90e8fd6b8daa43a3b711005
https://hdl.handle.net/10023/24657
https://hdl.handle.net/10023/24657
Autor:
Stephen J. Hill, Carsten Hoffmann, Ali Işbilir, Cristina Perpiñá-Viciano, Birgit Caspar, Martine J. Smit, Martin J. Lohse, Laura E. Kilpatrick, Aurélien Zarca
Publikováno v:
Molecular Pharmacology, 98(2), 72-87. American Society for Pharmacology and Experimental Therapeutics
Molecular Pharmacology
Perpiñá-Viciano, C, Işbilir, A, Zarca, A, Caspar, B, Kilpatrick, L E, Hill, S J, Smit, M J, Lohse, M J & Hoffmann, C 2020, ' Kinetic analysis of the early signaling steps of the human chemokine receptor CXCR4 ', Molecular Pharmacology, vol. 98, no. 2, pp. 72-87 . https://doi.org/10.1124/MOL.119.118448
Molecular Pharmacology
Perpiñá-Viciano, C, Işbilir, A, Zarca, A, Caspar, B, Kilpatrick, L E, Hill, S J, Smit, M J, Lohse, M J & Hoffmann, C 2020, ' Kinetic analysis of the early signaling steps of the human chemokine receptor CXCR4 ', Molecular Pharmacology, vol. 98, no. 2, pp. 72-87 . https://doi.org/10.1124/MOL.119.118448
G protein-coupled receptors (GPCRs) are biologic switches that transduce extracellular stimuli into intracellular responses in the cell. Temporally resolving GPCR transduction pathways is key to understanding how cell signaling occurs. Here, we inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f545a3ec6c48d3a361720872e1533c8
https://research.vu.nl/en/publications/ed31ddab-155e-4b2e-a3d0-9039bad482e7
https://research.vu.nl/en/publications/ed31ddab-155e-4b2e-a3d0-9039bad482e7
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
María I. Martínez-Jiménez, Cristina Perpiñá, Luis Blanco, Patricia A. Calvo, Susana Guerra, Guillermo Sastre-Moreno
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
PrimPol is a human primase/polymerase specialized in downstream repriming of stalled forks during both nuclear and mitochondrial DNA replication. Like most primases and polymerases, PrimPol requires divalent metal cations, as Mg2+ or Mn2+, used as co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21e0be56b77c90e44bcde7dca15332d
http://hdl.handle.net/10261/246714
http://hdl.handle.net/10261/246714
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Elke Butt, Katrin Stempfle, Lorenz Lister, Felix Wolf, Marcella Kraft, Andreas B. Herrmann, Cristina Perpina Viciano, Christian Weber, Andreas Hochhaus, Thomas Ernst, Carsten Hoffmann, Alma Zernecke, Jochen J. Frietsch
Publikováno v:
Cells, Vol 9, Iss 2, p 444 (2020)
The serine/threonine protein kinase AKT1 is a downstream target of the chemokine receptor 4 (CXCR4), and both proteins play a central role in the modulation of diverse cellular processes, including proliferation and cell survival. While in chronic my
Externí odkaz:
https://doaj.org/article/8ef30b034a774bc998ea77561cb82d7b
Autor:
Beatrice Oehler, Milad Mohammadi, Cristina Perpina Viciano, Dagmar Hackel, Carsten Hoffmann, Alexander Brack, Heike L. Rittner
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Antinociceptive pathways are activated in the periphery in inflammatory pain, for instance resolvins and opioid peptides. Resolvins are biosynthesized from omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid. Re
Externí odkaz:
https://doaj.org/article/ca92544efbd8408ba8bd7a53fac11bd1