Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Cristina Panuzzo"'
Autor:
Pietro Poggio, Stefania Rocca, Federica Fusella, Roberta Ferretti, Ugo Ala, Flora D’Anna, Emilia Giugliano, Cristina Panuzzo, Diletta Fontana, Valeria Palumbo, Giovanna Carrà, Daniela Taverna, Carlo Gambacorti-Passerini, Giuseppe Saglio, Carmen Fava, Rocco Piazza, Alessandro Morotti, Francesca Orso, Mara Brancaccio
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Morgana is a ubiquitous HSP90 co-chaperone protein coded by the CHORDC1 gene. Morgana heterozygous mice develop with age a myeloid malignancy resembling human atypical myeloid leukemia (aCML), now renamed MDS/MPN with neutrophilia. Patients
Externí odkaz:
https://doaj.org/article/6c827363c8c04882b2a5e5aa1fda4491
Publikováno v:
Biophysica, Vol 2, Iss 3, Pp 174-183 (2022)
From yeast to mammalian cells, ubiquitination is one of the most conserved, and reversible, eukaryotic post-translational modifications (PTMs) responsible for controlling nearly all cellular processes. Potentially, every single eukaryotic cell can ac
Externí odkaz:
https://doaj.org/article/cba7ec58aa7940dc9e3dd1f386c04ea5
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13069 (2023)
In the era of personalized medicine greatly improved by molecular diagnosis and tailor-made therapies, the survival rate of acute myeloid leukemia (AML) at 5 years remains unfortunately low. Indeed, the high heterogeneity of AML clones with distinct
Externí odkaz:
https://doaj.org/article/be56f00260e941e88437fe9ae9b62920
Autor:
Cristina Panuzzo, Lucrezia Pironi, Alessandro Maglione, Simone Rocco, Serena Stanga, Chiara Riganti, Joanna Kopecka, Muhammad Shahzad Ali, Barbara Pergolizzi, Enrico Bracco, Daniela Cilloni
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1234 (2023)
Hypoxia is a critical condition that governs survival, self-renewal, quiescence, metabolic shift and refractoriness to leukemic stem cell (LSC) therapy. The present study aims to investigate the hypoxia-driven regulation of the mammalian Target of th
Externí odkaz:
https://doaj.org/article/c5a5a0ab9e314f21973a8a9481fc9d3d
Autor:
Marta Biondo, Cristina Panuzzo, Shahzad M. Ali, Salvatore Bozzaro, Matteo Osella, Enrico Bracco, Barbara Pergolizzi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
In aerobic organisms, oxygen is essential for efficient energy production, and it acts as the last acceptor of the mitochondrial electron transport chain and as regulator of gene expression. However, excessive oxygen can lead to production of deleter
Externí odkaz:
https://doaj.org/article/1da648d9d26742279a7e89b99b0a6359
Autor:
Chiara Calabrese, Cristina Panuzzo, Serena Stanga, Giacomo Andreani, Silvia Ravera, Alessandro Maglione, Lucrezia Pironi, Jessica Petiti, Muhammad Shahzad Ali, Patrizia Scaravaglio, Francesca Napoli, Carmen Fava, Marco De Gobbi, Francesco Frassoni, Giuseppe Saglio, Enrico Bracco, Barbara Pergolizzi, Daniela Cilloni
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7674 (2020)
Iron is crucial to satisfy several mitochondrial functions including energy metabolism and oxidative phosphorylation. Patients affected by Myelodysplastic Syndromes (MDS) and acute myeloid leukemia (AML) are frequently characterized by iron overload
Externí odkaz:
https://doaj.org/article/5aa53958631e4bb6a5f58dcc36f456f1
Autor:
Cristina Panuzzo, Aleksandar Jovanovski, Barbara Pergolizzi, Lucrezia Pironi, Serena Stanga, Carmen Fava, Daniela Cilloni
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 3928 (2020)
Mitochondria are the main fascinating energetic source into the cells. Their number, shape, and dynamism are controlled by the cell’s type and current behavior. The perturbation of the mitochondrial inward system via stress response and/or oncogeni
Externí odkaz:
https://doaj.org/article/4ace3f3a872a49edb0928789fd2f24e3
Autor:
Alessandro Morotti, Cristina Panuzzo, Sabrina Crivellaro, Giovanna Carra', Davide Torti, Angelo Guerrasio, Giuseppe Saglio
Publikováno v:
Hematology Reports, Vol 7, Iss 4 (2015)
PTEN deletion in the mouse and in the zebrafish highlights the essential role of this tumor suppressor in the development of myeloid malignancies, in particular acute myeloid leukemia and myeloproliferative disorders. In humans, extensive genetic seq
Externí odkaz:
https://doaj.org/article/430527d8096e4c639dd263f39d00d01f
Autor:
Alessandro Morotti, Giovanna Carrà, Cristina Panuzzo, Sabrina Crivellaro, Riccardo Taulli, Angelo Guerrasio, Giuseppe Saglio
Publikováno v:
Advances in Hematology, Vol 2015 (2015)
BCR-ABL-mediated leukemias, either Chronic Myeloid Leukemia (CML) or Philadelphia positive Acute Lymphoblastic Leukemia (ALL), are the paradigm of targeted molecular therapy of cancer due to the impressive clinical responses obtained with BCR-ABL spe
Externí odkaz:
https://doaj.org/article/2f0e0c12d4bc4753bf96afd54d1a805b
Autor:
Cristina Panuzzo, Sabrina Crivellaro, Giovanna Carrà, Angelo Guerrasio, Giuseppe Saglio, Alessandro Morotti
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110682 (2014)
Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the t(9;22) translocation coding for the chimeric protein p210 BCR-ABL. The tumor suppressor PTEN plays a critical role in the pathogenesis of CML chronic phase, through
Externí odkaz:
https://doaj.org/article/6ae88d0da46641cb94deb626f7db34a5