Discovery of ginisortamab, a potent and novel anti-gremlin-1 antibody in clinical development for the treatment of cancer

Autor: Gareth C. G. Davies, Neesha Dedi, Paul S. Jones, Lara Kevorkian, David McMillan, Cristina Ottone, Monika-Sarah E. D. Schulze, Anthony Scott-Tucker, Roohi Tewari, Shauna West, Michael Wright, Tania F. Rowley

Publikováno v: mAbs, Vol 15, Iss 1 (2023)

ABSTRACTGremlin-1, a high-affinity antagonist of bone morphogenetic proteins (BMP)-2, −4, and −7, is implicated in tumor initiation and progression. Increased gremlin-1 expression, and therefore suppressed BMP signaling, correlates with poor prog

Externí odkaz: https://doaj.org/article/b953f7c54c694fe2b318ac8406c9743d

Multifaceted control of adult SVZ neurogenesis by the vascular niche

Autor: Cristina Ottone, Simona Parrinello

Publikováno v: Cell Cycle. 14:2222-2225

The subventricular zone is one of the 2 germinal niches of the adult brain where neural stem cells (NSC) generate new neurons and glia throughout life. NSC behavior is controlled by the integration of intrinsic signals and extrinsic cues provided by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf1c8fa6a9e4290e3ea8fa164873774
https://doi.org/10.1080/15384101.2015.1049785

EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells

Autor: Sanjay Khadayate, Cristina Ottone, Huang Lieven, Benjamin Krusche, Ewan Johnstone, Azhaar Ashraf, Vincenzo De Paola, Melanie Clements, Tim K. Davies, Katrin Goetsch, Poonam Singh, Simona Parrinello, Jorge L. Martínez-Torrecuadrada, Steven M. Pollard, Paul Bertone, Silvia G Mota, Federico Roncaroli

Publikováno v: Krusche, B, Ottone, C, Clements, M P, Johnstone, E R, Goetsch, K, Lieven, H, Mota, S G, Singh, P, Khadayate, S, Ashraf, A, Davies, T, Pollard, S M, De Paola, V, Roncaroli, F, Martinez-torrecuadrada, J, Bertone, P & Parrinello, S 2016, ' EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells ', eLIFE, vol. 5 . https://doi.org/10.7554/eLife.14845
eLife, Vol 5 (2016)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Europe PubMed Central
eLife
Krusche, B, Ottone, C, Clements, M P, Johnstone, E R, Goetsch, K, Lieven, H, Mota, S G, Singh, P, Khadayate, S, Ashraf, A, Davies, T, Pollard, S M, De Paola, V, Roncaroli, F, Martinez-Torrecuadrada, J, Bertone, P & Parrinello, S 2016, ' EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells ', eLife, vol. 5, e14845 . https://doi.org/10.7554/eLife.14845.001

Glioblastomas (GBM) are aggressive and therapy-resistant brain tumours, which contain a subpopulation of tumour-propagating glioblastoma stem-like cells (GSC) thought to drive progression and recurrence. Diffuse invasion of the brain parenchyma, incl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7b1270bd2d5cb34af1f9fce682a2b5
https://hdl.handle.net/20.500.11820/66eaef89-cd0f-422b-82f8-f76623dc354b

The translational repressor Cup is required for germ cell development in Drosophila

Autor: Angela Giangrande, Cristina Ottone, Silvia Gigliotti, Franco Graziani, Arturo Verrotti di Pianella

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2012, ⟨10.1242/jcs.095208⟩
Journal of cell science 125 (2012): 3114–3123. doi:10.1242/jcs.095208
info:cnr-pdr/source/autori:Ottone C.; Gigliotti S.; Giangrande A.; Graziani, F.; di Pianella A.V./titolo:The translational repressor Cup is required for germ cell development in Drosophila/doi:10.1242%2Fjcs.095208/rivista:Journal of cell science/anno:2012/pagina_da:3114/pagina_a:3123/intervallo_pagine:3114–3123/volume:125

International audience; In Drosophila, germ cell formation depends on inherited maternal factors localized in the posterior pole region of oocytes and early embryos, known as germ plasm. Here, we report that heterozygous cup mutant ovaries and embryo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c5c8d815d071bae3f23c24c4c2c97c
https://hal.archives-ouvertes.fr/hal-03447894

The translational repressor Cup associates with the adaptor protein Miranda and the mRNA carrier Staufen at multiple time-points during Drosophila oogenesis

Autor: Paola Brescia, Alessia Galasso, Federica Piccioni, Gabriella Siciliano, Cristina Ottone, Silvia Gigliotti, Arturo C. Verrotti, Franco Graziani, Viviana Pisa

Publikováno v: Gene (Amst.) 428 (2009): 47–52. doi:10.1016/j.gene.2008.09.019
info:cnr-pdr/source/autori:Piccioni F.; Ottone C.; Brescia P.; Pisa V.; Siciliano G.; Galasso A.; Gigliotti S.; Graziani F.; Verrotti A.C./titolo:The translational repressor Cup associates with the adaptor protein Miranda and the mRNA carrier Staufen at multiple time-points during Drosophila oogenesis/doi:10.1016%2Fj.gene.2008.09.019/rivista:Gene (Amst.)/anno:2009/pagina_da:47/pagina_a:52/intervallo_pagine:47–52/volume:428

In Drosophila melanogaster, Cup acts as a translational regulator during oocyte maturation and early embryogenesis. In this report, we show that Cup associates with Miranda, an adaptor protein involved in localization of specific mRNA complexes in bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ac3ac1e5f2778b93649da6735a297c
https://publications.cnr.it/doc/26792