LncRNA ARGI Contributes to Virus‐Induced Pancreatic β Cell Inflammation Through Transcriptional Activation of IFN‐Stimulated Genes

Autor: Itziar González‐Moro, Koldo Garcia‐Etxebarria, Luis Manuel Mendoza, Nora Fernández‐Jiménez, Jon Mentxaka, Ane Olazagoitia‐Garmendia, María Nicol Arroyo, Toshiaki Sawatani, Cristina Moreno‐Castro, Chiara Vinci, Anne Op de Beek, Miriam Cnop, Mariana Igoillo‐Esteve, Izortze Santin

Publikováno v: Advanced Science, Vol 10, Iss 25, Pp n/a-n/a (2023)

Abstract Type 1 diabetes (T1D) is a complex autoimmune disease that develops in genetically susceptible individuals. Most T1D‐associated single nucleotide polymorphisms (SNPs) are located in non‐coding regions of the human genome. Interestingly,

Externí odkaz: https://doaj.org/article/e0b08b72f8934629b39760d37febee3a

Innovative Therapeutic and Delivery Approaches Using Nanotechnology to Correct Splicing Defects Underlying Disease

Autor: Marc Suñé-Pou, María J. Limeres, Cristina Moreno-Castro, Cristina Hernández-Munain, Josep M. Suñé-Negre, María L. Cuestas, Carlos Suñé

Publikováno v: Frontiers in Genetics, Vol 11 (2020)

Alternative splicing of pre-mRNA contributes strongly to the diversity of cell- and tissue-specific protein expression patterns. Global transcriptome analyses have suggested that >90% of human multiexon genes are alternatively spliced. Alterations in

Externí odkaz: https://doaj.org/article/24b50357724844d5b9421be20eb53e2a

GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models

Autor: Vyron Gorgogietas, Bahareh Rajaei, Chae Heeyoung, Bruno J. Santacreu, Sandra Marín-Cañas, Paraskevi Salpea, Toshiaki Sawatani, Anyishai Musuaya, María N. Arroyo, Cristina Moreno-Castro, Khadija Benabdallah, Celine Demarez, Sanna Toivonen, Cristina Cosentino, Nathalie Pachera, Maria Lytrivi, Ying Cai, Lode Carnel, Cris Brown, Fumihiko Urano, Piero Marchetti, Patrick Gilon, Decio L. Eizirik, Miriam Cnop, Mariana Igoillo-Esteve

Publikováno v: Diabetologia, Vol. 66, no.7, p. 1306-1321 (2023)

Aims/hypothesis Wolfram syndrome is a rare autosomal recessive disorder caused by pathogenic variants in the WFS1 gene. It is characterised by insulin-dependent diabetes mellitus, optic nerve atrophy, diabetes insipidus, hearing loss and neurodegener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c323abf826fb8049db46bad1f9fe4197
https://hdl.handle.net/2078.1/275993

Innovative Therapeutic and Delivery Approaches Using Nanotechnology to Correct Splicing Defects Underlying Disease

Autor: María Luján Cuestas, Cristina Hernández-Munain, Cristina Moreno-Castro, Marc Suñé-Pou, Josep M. Suñé-Negre, Carlos Suñé, María J. Limeres

Publikováno v: Frontiers in Genetics, Vol 11 (2020)
Dipòsit Digital de la UB
Universidad de Barcelona
Frontiers in Genetics
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Alternative splicing of pre-mRNA contributes strongly to the diversity of cell- and tissue-specific protein expression patterns. Global transcriptome analyses have suggested that >90% of human multiexon genes are alternatively spliced. Alterations in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f537e671ab99cd918b49e537a4ac7dc6
https://www.frontiersin.org/article/10.3389/fgene.2020.00731/full

Role for the splicing factor TCERG1 in Cajal body integrity and snRNP assembly

Autor: Cristina Moreno-Castro, Silvia Prieto-Sánchez, Cristina Hernández-Munain, Carlos Suñé, Noemí Sánchez-Hernández

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Este artículo ha sido seleccionado para su inclusión en la sección “Research Highlights” de la revista.
Cajal bodies are nuclear organelles involved in the nuclear phase ofsmall nuclear ribonucleoprotein (snRNP) biogenesis. In this study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc9326c9ddd0733fd8734c9b3ea302f
https://pubmed.ncbi.nlm.nih.gov/31636114