Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Cristina Moldovan Loomis"'
Autor:
Theodore J. Price, Amanda Avona, Gregory Dussor, Marina Motina, Jacob Lackovic, Lilyana Quigley, Carolina C. Burgos-Vega, Bianca N. Mason, Armen N. Akopian, Leon F. Garcia-Martinez, Cristina Moldovan Loomis, Naureen Wajahat
Publikováno v:
Pain
Migraine is one of the most disabling disorders worldwide but the underlying mechanisms are poorly understood. Stress is consistently reported as a common trigger of migraine attacks. Here, we show that repeated stress in mice causes migraine-like be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c723d466254360429224230ecb1fd3c2
https://doi.org/10.1097/j.pain.0000000000001953
https://doi.org/10.1097/j.pain.0000000000001953
Autor:
Brian Baker, Dan Scott Allison, Lee Hendrix, David Jurchen, Susan Pederson, Heidi Boshaw, Sam Marzolf, Jens J. Billgren, John A. Latham, Vanessa Lisbeth Rubin, Gayle Kwon, Cristina Moldovan Loomis, Leon F. Garcia-Martinez, Pei Fan, Roger Cady, Erica Stewart, Ethan W. Ojala, Charlie Karasek, Jenny Mulligan, Michelle Scalley-Kim, Lisa Perrino McCulloch, Benjamin H. Dutzar
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 369:26-36
Migraine is a debilitating disease that affects almost 15% of the population worldwide and is the first cause of disability in people under 50 years of age, yet its etiology and pathophysiology remain incompletely understood. Recently, small molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e3f8852a602b73f4e4c6293c6e0865
https://doi.org/10.1124/jpet.118.253443
https://doi.org/10.1124/jpet.118.253443
Autor:
Levi P. Sowers, Cristina Moldovan Loomis, Alyssa S. Reis, Anne-Sophie Wattiez, Leon F. Garcia-Martinez, Benjamin Hing, Adisa Kuburas, Andrew F. Russo, Bianca N. Mason
Publikováno v:
J Neurosci
The neuropeptides CGRP (calcitonin gene-related peptide) and PACAP (pituitary adenylate cyclase-activating polypeptide) have emerged as mediators of migraine, yet the potential overlap of their mechanisms remains unknown. Infusion of PACAP, like CGRP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668b0a1fa4bd8cd206655ed3fcad2571
https://pubmed.ncbi.nlm.nih.gov/33846231
https://pubmed.ncbi.nlm.nih.gov/33846231
Autor:
Bianca N. Mason, Levi P. Sowers, Cristina Moldovan Loomis, Alyssa S. Reis, Andrew F. Russo, Leon F. Garcia-Martinez, Benjamin Hing, Adisa Kuburas
The neuropeptides CGRP and PACAP have emerged as mediators of migraine, yet the potential overlap of their mechanisms remains unknown. Infusion of PACAP, like CGRP, can cause migraine in people, and both peptides share similar vasodilatory and nocice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3be26cd72469d373a5fb74c67f1e7d3b
https://doi.org/10.1101/2020.08.20.255968
https://doi.org/10.1101/2020.08.20.255968
Autor:
Aaron M. Fairbanks, Maria-Cristina Moldovan-Loomis, Leon F. Garcia-Martinez, Pieter Poolman, Jayme S Waite, Levi P. Sowers, Cameron J Brown, Bennett R Robertson, Andrew F. Russo, William C Castonguay, Bianca N. Mason, Chantel M Schmidt, Johannes Ledolter, Anne-Sophie Wattiez, Randy H. Kardon, Brandon J. Rea
Publikováno v:
Pain. 159:2306-2317
Migraine is the third most common disease in the world (behind dental caries and tension-type headache) with an estimated global prevalence of 15%, yet its etiology remains poorly understood. Recent clinical trials have heralded the potential of ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bbf3ccfd4cc25f1765b0047ce55f351
https://doi.org/10.1097/j.pain.0000000000001337
https://doi.org/10.1097/j.pain.0000000000001337
Autor:
Benjamin H. Dutzar, Robert Bader, Cristina Moldovan Loomis, Yulia Ovechkina, Shawn P. Iadonato, Remington Lance, David Peckham, Emily Frazier, Shaarwari Sridhar, Nathan Eyde, David Jurchen, Jeff Posakony, Mei Xu, Kurt Lustig, Thierry Guillaudeux, Eric J. Tarcha
Publikováno v:
Cancer Research. 81:1637-1637
V-domain Immunoglobulin Suppressor of T cell Activation (VISTA/PD-1H) is an immune checkpoint regulator of the B7 family. VISTA can be found on the cell surface of some tumor types, however for the majority of cancers, VISTA is highly expressed in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ee702bca20eca3a99485a9ca6c51c69
https://doi.org/10.1158/1538-7445.am2021-1637
https://doi.org/10.1158/1538-7445.am2021-1637
Autor:
Jeff Posakony, Thierry Guillaudeux, Robert Bader, Kurt Lustig, Remington Lance, Shawn P. Iadonato, Emily Frazier, Mei Xu, David Peckham, Benjamin H. Dutzar, Shaarwari Sridhar, Eric J. Tarcha, Nathan Eyde, Yulia Ovechkina, Cristina Moldovan Loomis, David Jurchen
Publikováno v:
Cancer Immunology Research. 9:PR005-PR005
V-domain Immunoglobulin Suppressor of T cell Activation (VISTA/PD-1H) is a B7 family ligand expressed on circulating and intratumoural myeloid cells as well as Treg and NK cells. It has been shown to inhibit T cell responses in vitro and in preclinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a2f8cd7cd450498892c61ad923317dc
https://doi.org/10.1158/2326-6074.tumimm20-pr005
https://doi.org/10.1158/2326-6074.tumimm20-pr005
Autor:
Ben Preston, Jie Liu, Michelle R. Kuhne, Amie Pham, Sharline Chen, Diann Blanset, Chetana Rao-Naik, Haichun Huang, Pina M. Cardarelli, Chin Pan, Alison Witte, Maria-Cristina Moldovan-Loomis, David J. King, David Passmore
Publikováno v:
Cancer Immunology, Immunotherapy. 59:257-265
A human anti-CD19 antibody was expressed in fucosyltransferase-deficient CHO cells to generate nonfucosylated MDX-1342. Binding of MDX-1342 to human CD19-expressing cells was similar to its fucosylated parental antibody. However, MDX-1342 exhibited i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e507b0ec0016da8d1cb8e542eb58f9
https://doi.org/10.1007/s00262-009-0746-z
https://doi.org/10.1007/s00262-009-0746-z
Autor:
Michelle Kuhne, Robert Graziano, David J. King, Alison Witte, Maria-Cristina Moldovan-Loomis, Jie Liu, Ben Preston, Tseng-Hui Chen, Mohan Srinivasan, Sharline Chen, David Passmore, Pina M. Cardarelli, Albert Assad, Amelia Black
Publikováno v:
Clinical Cancer Research. 15:3376-3383
Purpose: This study was undertaken to evaluate the effects of MDX-1401, a nonfucosylated fully human monoclonal antibody that binds to human CD30, and to determine whether it exhibits greater in vitro and in vivo activity than its parental antibody.E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47203ab9d7f7846e6a34ab97b7411be2
https://doi.org/10.1158/1078-0432.ccr-08-3222
https://doi.org/10.1158/1078-0432.ccr-08-3222
Autor:
John R. Gasdaska, Jeffrey T. Regan, Jason D. Sterling, Lynn F. Dickey, Kevin M. Cox, David Passmore, Pina M. Cardarelli, Mohan Srinivasan, Amelia Black, Charles G. Peele, Cristina Moldovan-Loomis, Karen K Frantz, Severino Cuison
Publikováno v:
Nature Biotechnology. 24:1591-1597
N-glycosylation is critical to the function of monoclonal antibodies (mAbs) and distinguishes various systems used for their production. We expressed human mAbs in the small aquatic plant Lemna minor, which offers several advantages for manufacturing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c21b7245fdaa01cae70856916f8f65
https://doi.org/10.1038/nbt1260
https://doi.org/10.1038/nbt1260