Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Cristina Miazzi"'
Autor:
Vera Bianchi, Peter Reichard, Paola Ferraro, Chiara Rampazzo, Giovanna Pontarin, Cristina Miazzi
Publikováno v:
The Journal of Biological Chemistry
Background: Genetic loss of SAMHD1, a catabolic enzyme preventing dNTP accumulation outside S phase, leads to disease in humans but not in mice. Results: Allosteric regulation by dNTPs works similarly in pure recombinant human and mouse SAMHD1. Concl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45969bba4ffbdba8356e7fc23e1b0eab
http://europepmc.org/articles/PMC4140260
http://europepmc.org/articles/PMC4140260
Autor:
Giovanna Pontarin, Vera Bianchi, Cristina Miazzi, Elisa Franzolin, Paola Ferraro, Peter Reichard, Chiara Rampazzo, Elisa Palumbo
Sterile alpha motif and HD-domain containing protein 1 (SAMHD1) is a triphosphohydrolase converting deoxynucleoside triphosphates (dNTPs) to deoxynucleosides. The enzyme was recently identified as a component of the human innate immune system that re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc426ddcd4251cb5758b2deff7cbce9
http://hdl.handle.net/11577/2667452
http://hdl.handle.net/11577/2667452
Autor:
Chiara Rampazzo, Elisa Franzolin, Vera Bianchi, Elisa Palumbo, Cristina Miazzi, Miriam Frangini
Publikováno v:
Experimental cell research. 318(17)
In cycling cells cytosolic de novo synthesis of deoxynucleotides is the main source of precursors for mitochondrial (mt) DNA synthesis. The transfer of deoxynucleotides across the inner mt membrane requires protein carriers. PNC1, a SLC25 family memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1a06a64f198e1a851636723218e387
https://pubmed.ncbi.nlm.nih.gov/22677043
https://pubmed.ncbi.nlm.nih.gov/22677043
Autor:
Miriam Frangini, Vera Bianchi, Peter Reichard, Paola Ferraro, Giovanna Pontarin, Cristina Miazzi, Chiara Rampazzo, Elisa Franzolin
Publikováno v:
Mutation research. 703(1)
Deoxyribonucleoside triphosphates (dNTPs) are the precursors used by DNA polymerases for replication and repair of nuclear and mitochondrial DNA in animal cells. Accurate DNA synthesis requires adequate amounts of each dNTP and appropriately balanced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20b1c923d65044d5c4e17713c052389
https://pubmed.ncbi.nlm.nih.gov/20561600
https://pubmed.ncbi.nlm.nih.gov/20561600
Publikováno v:
Experimental cell research. 316(20)
The deoxyguanosine (GdR) analog guanine-s-d-arabinofuranoside (araG) has a specific toxicity for T lymphocytes. Also GdR is toxic for T lymphocytes, provided its degradation by purine nucleoside phosphorylase (PNP) is prevented, by genetic loss of PN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a5c5c48653009f6a5389e59bd941fc
https://pubmed.ncbi.nlm.nih.gov/20603113
https://pubmed.ncbi.nlm.nih.gov/20603113