Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Cristina M Alberini"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010239 (2022)
Key features of long-term memory (LTM), such as its stability and persistence, are acquired during processes collectively referred to as consolidation. The dynamics of biological changes during consolidation are complex. In adult rodents, consolidati
Externí odkaz:
https://doaj.org/article/ce84d98358414293bffdb05b0ef3b7f5
Publikováno v:
eLife, Vol 10 (2021)
The metabolic mechanisms underlying the formation of early-life episodic memories remain poorly characterized. Here, we assessed the metabolomic profile of the rat hippocampus at different developmental ages both at baseline and following episodic le
Externí odkaz:
https://doaj.org/article/0465be4af6d54d64acf1da9a14ec6e98
Publikováno v:
eLife, Vol 9 (2020)
Cation-independent mannose-6-phosphate receptor, also called insulin-like growth factor two receptor (CIM6P/IGF2R), plays important roles in growth and development, but is also extensively expressed in the mature nervous system, particularly in the h
Externí odkaz:
https://doaj.org/article/e5f165b492894513bdd49003434af638
Autor:
Maria Pascual‐Lucas, Silvia Viana da Silva, Marianna Di Scala, Carolina Garcia‐Barroso, Gloria González‐Aseguinolaza, Christophe Mulle, Cristina M Alberini, Mar Cuadrado‐Tejedor, Ana Garcia‐Osta
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 10, Pp 1246-1262 (2014)
Abstract Insulin‐like growth factor 2 (IGF2) was recently found to play a critical role in memory consolidation in rats and mice, and hippocampal or systemic administration of recombinant IGF2 enhances memory. Here, using a gene therapy‐based app
Externí odkaz:
https://doaj.org/article/912759b800874d93875faf0e67d55253
Publikováno v:
Frontiers in Integrative Neuroscience, Vol 10 (2016)
Long-term memory formation, the ability to retain information over time about an experience, is a complex function that affects multiple behaviors, and is an integral part of an individual’s identity. In the last 50 years many scientists have focus
Externí odkaz:
https://doaj.org/article/961cbfa17e064ebc92e573284eff7119
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141078 (2015)
Insulin like growth factor 2 (Igf2) is known as a maternally imprinted gene involved in growth and development. Recently, Igf2 was found to also be regulated and required in the adult rat hippocampus for long-term memory formation, raising the questi
Externí odkaz:
https://doaj.org/article/113b47fdddda4c3ca28b088dfa5c896c
Autor:
Cristina M Alberini
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 5 (2011)
It is becoming increasingly clear that the processes of memory formation and storage are exquisitely dynamic. Elucidating the nature and temporal evolution of the biological changes that accompany encoding, storage and retrieval is key to understand
Externí odkaz:
https://doaj.org/article/01c639d20b8e43a5b7524b43bcf927bc
Publikováno v:
PLoS Biology, Vol 3, Iss 9, p e293 (2005)
A new memory is initially labile and becomes stabilized through a process of consolidation, which depends on gene expression. Stable memories, however, can again become labile if reactivated by recall and require another phase of protein synthesis in
Externí odkaz:
https://doaj.org/article/9a9e073a607048f68665a4795bf58aa9
Autor:
Rocco Pizzarelli, Domenico Pimpinella, Christian Jacobs, Alice Tartacca, Uarda Kullolli, Hannah Monyer, Cristina M. Alberini, Marilena Griguoli
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2024)
Autism spectrum disorders (ASDs) comprise developmental disabilities characterized by impairments of social interaction and repetitive behavior, often associated with cognitive deficits. There is no current treatment that can ameliorate most of the A
Externí odkaz:
https://doaj.org/article/a8ad59e2860d48f0b783986ca701715f
Publikováno v:
Glia. 70:2207-2231
The consumption of glucose in the brain peaks during late childhood; yet, whether and how glucose metabolism is differentially regulated in the brain during childhood compared to adulthood remains to be understood. In particular, it remains to be det