Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Cristina M, Furdui"'
Autor:
Flavio R. Palma, Diego R. Coelho, Kirthi Pulakanti, Marcelo J. Sakiyama, Yunping Huang, Fernando T. Ogata, Jeanne M. Danes, Alison Meyer, Cristina M. Furdui, Douglas R. Spitz, Ana P. Gomes, Benjamin N. Gantner, Sridhar Rao, Vadim Backman, Marcelo G. Bonini
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114415- (2024)
Externí odkaz:
https://doaj.org/article/425e2d4d57dd43c7b3fb3e7ae2f1fbd1
Autor:
Morgan C. Pait, Sarah D. Kaye, Yixin Su, Ashish Kumar, Sangeeta Singh, Stephen C. Gironda, Samantha Vincent, Maria Anwar, Caitlin M. Carroll, James Andy Snipes, Jingyun Lee, Cristina M. Furdui, Gagan Deep, Shannon L. Macauley
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 1, Pp n/a-n/a (2024)
Abstract Brain‐derived extracellular vesicles (EVs) play an active role in Alzheimer's disease (AD), relaying important physiological information about their host tissues. The internal cargo of EVs is protected from degradation, making EVs attracti
Externí odkaz:
https://doaj.org/article/5903d2405b69485391b6d5b52d9d7a03
Autor:
Kimberly M. Burcher, Chance H. Bloomer, Elena Gavrila, John M. Kalada, Mark J. Chang, Rediet R. Gebeyehu, Alexander H. Song, Lara M. Khoury, Thomas W. Lycan, Rebecca Kinney, Ralph D’Agostino, Paul M. Bunch, Kirtikar Shukla, Pierre Triozzi, Cristina M. Furdui, Wei Zhang, Mercedes Porosnicu
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Background: Immunotherapy with programmed death receptor-1 (PD-1) inhibitors, as a single agent or in combination with chemotherapy, is the standard first-line treatment for recurrent or metastatic head and neck squamous cell cancer (R/M HNSCC). Unfo
Externí odkaz:
https://doaj.org/article/4b2b3487d94347f3b131d6d499c50ee5
Autor:
Maithily S. Nanadikar, Ana M. Vergel Leon, Jia Guo, Gijsbert J. van Belle, Aline Jatho, Elvina S. Philip, Astrid F. Brandner, Rainer A. Böckmann, Runzhu Shi, Anke Zieseniss, Carla M. Siemssen, Katja Dettmer, Susanne Brodesser, Marlen Schmidtendorf, Jingyun Lee, Hanzhi Wu, Cristina M. Furdui, Sören Brandenburg, Joseph R. Burgoyne, Ivan Bogeski, Jan Riemer, Arpita Chowdhury, Peter Rehling, Tobias Bruegmann, Vsevolod V. Belousov, Dörthe M. Katschinski
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Redox signaling and cardiac function are tightly linked. However, it is largely unknown which protein targets are affected by hydrogen peroxide (H2O2) in cardiomyocytes that underly impaired inotropic effects during oxidative stress. Here, w
Externí odkaz:
https://doaj.org/article/46b0dc091943496094992a4e0a96de5f
Autor:
Anthony E. Postiglione, Laquaundra L. Adams, Ese S. Ekhator, Anuoluwapo E. Odelade, Supriya Patwardhan, Meenal Chaudhari, Avery S. Pardue, Anjali Kumari, William A. LeFever, Olivia P. Tornow, Tamer S. Kaoud, Johnathan Neiswinger, Jun Seop Jeong, Derek Parsonage, Kimberly J. Nelson, Dukka B. Kc, Cristina M. Furdui, Heng Zhu, Andrew J. Wommack, Kevin N. Dalby, Ming Dong, Leslie B. Poole, Jeremiah D. Keyes, Robert H. Newman
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107817- (2023)
Summary: Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are dysregulated in many pervasive diseases. Recently, we discovered that ERK1/2 is oxidized by signal-generated hydrogen peroxide in various cell types. Since the putative sites of oxi
Externí odkaz:
https://doaj.org/article/f86f308d6824464da8ac7565dac3a50d
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 8, Pp 100405- (2023)
Alpha/beta hydrolase domain-containing protein 4 (ABHD4) catalyzes the deacylation of N-acyl phosphatidyl-ethanolamine (NAPE) and lyso-NAPE to produce glycerophospho-N-acyl ethanolamine (GP-NAE). Through a variety of metabolic enzymes, NAPE, lyso-NAP
Externí odkaz:
https://doaj.org/article/a53e4e26bdd644f1b32f7c705220fdac
Autor:
Allison K. Meyers, Zhan Wang, Wenzheng Han, Qingxia Zhao, Manal Zabalawi, Likun Duan, Juan Liu, Qianyi Zhang, Rajesh K. Manne, Felipe Lorenzo, Matthew A. Quinn, Qianqian Song, Daping Fan, Hui-Kuan Lin, Cristina M. Furdui, Jason W. Locasale, Charles E. McCall, Xuewei Zhu
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111941- (2023)
Summary: Activating the macrophage NLRP3 inflammasome can promote excessive inflammation with severe cell and tissue damage and organ dysfunction. Here, we show that pharmacological or genetic inhibition of pyruvate dehydrogenase kinase (PDHK) signif
Externí odkaz:
https://doaj.org/article/9e44575ee34a4202a7a3e462e4561170
Autor:
Zhiwei Ji, Jade Moore, Nelmi O. Devarie-Baez, Joshua Lewis, Hanzhi Wu, Kirtikar Shukla, Elsa I. Silva Lopez, Victor Vitvitsky, Chia-Chi Chuang Key, Mercedes Porosnicu, Melissa L. Kemp, Ruma Banerjee, John S. Parks, Allen W. Tsang, Xiaobo Zhou, Cristina M. Furdui
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
Redox metabolism is increasingly investigated in cancer as driving regulator of tumor progression, response to therapies and long-term patients’ quality of life. Well-established cancer therapies, such as radiotherapy, either directly impact redox
Externí odkaz:
https://doaj.org/article/c75a8e2c322c48399549133e5108b486
Autor:
Monica M. Rohde, Christina M. Snyder, John Sloop, Shane R. Solst, George L. Donati, Douglas R. Spitz, Cristina M. Furdui, Ravi Singh
Publikováno v:
Particle and Fibre Toxicology, Vol 18, Iss 1, Pp 1-24 (2021)
Abstract Background Precisely how silver nanoparticles (AgNPs) kill mammalian cells still is not fully understood. It is not clear if AgNP-induced damage differs from silver cation (Ag+), nor is it known how AgNP damage is transmitted from cell membr
Externí odkaz:
https://doaj.org/article/a5a5b61ac5444a9fb713424c28b1ddae
Autor:
Anna Bianchi-Smiraglia, David W. Wolff, Daniel J. Marston, Zhiyong Deng, Zhannan Han, Sudha Moparthy, Rebecca M. Wombacher, Ashley L. Mussell, Shichen Shen, Jialin Chen, Dong-Hyun Yun, Anderson O’Brien Cox, Cristina M. Furdui, Edward Hurley, Maria Laura Feltri, Jun Qu, Thomas Hollis, Jules Berlin Nde Kengne, Bernard Fongang, Rui J. Sousa, Mikhail E. Kandel, Eugene S. Kandel, Klaus M. Hahn, Mikhail A. Nikiforov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Changes in intracellular GTP levels are not considered as a regulatory event in RAC1 activation in live cells since total GTP levels are substantially higher than the RAC1 GTP dissociation constant determined in vitro. Here, the authors demonstrate t
Externí odkaz:
https://doaj.org/article/8aee079d643942f4a47c971818bffc85