Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Cristina Lecci"'
Autor:
Stephen G. Davies, Angela J. Russell, Enrico Emer, Sarah E. Squire, Maria Chatzopoulou, Francis Xavier Wilson, Lee Moir, Anne-Sophie Casagrande, Kay E. Davies, Jessica A. Rowley, Graham Michael Wynne, Cristina Lecci, Shawn Harriman
Publikováno v:
ACS Med Chem Lett
[Image: see text] Utrophin modulation is a disease-modifying therapeutic strategy for Duchenne muscular dystrophy that would be applicable to all patient populations. To improve the suboptimal profile of ezutromid, the first-in-class clinical candida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f034da3591b87b632ce8c2271cfa3f61
https://doi.org/10.1021/acsmedchemlett.0c00405
https://doi.org/10.1021/acsmedchemlett.0c00405
Autor:
Arran Babbs, Jessica A. Rowley, Stephen G. Davies, Adam Berg, Benjamin Edwards, Simon Guiraud, Graham Michael Wynne, Cristina Lecci, Maria Chatzopoulou, Lee Moir, Enrico Emer, Shawn Harriman, Neil Robinson, Francis Xavier Wilson, David Peters, Sarah E. Squire, D. Elsey, Kay E. Davies, Angela J. Russell, Jonathon M. Tinsley
Publikováno v:
Journal of Medicinal Chemistry. 63:7880-7891
Utrophin modulation is a promising therapeutic strategy for Duchenne muscular dystrophy (DMD), which should be applicable to all patient populations. Following on from ezutromid, the first-generation utrophin modulator, we describe the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da6ec2d0aa4a2f0a1bb2337a0bf820b5
https://doi.org/10.1021/acs.jmedchem.0c00807
https://doi.org/10.1021/acs.jmedchem.0c00807
Autor:
Arran, Babbs, Adam, Berg, Maria, Chatzopoulou, Kay E, Davies, Stephen G, Davies, Benjamin, Edwards, David J, Elsey, Enrico, Emer, Simon, Guiraud, Shawn, Harriman, Cristina, Lecci, Lee, Moir, David, Peters, Neil, Robinson, Jessica A, Rowley, Angela J, Russell, Sarah E, Squire, Jonathon M, Tinsley, Francis X, Wilson, Graham M, Wynne
Publikováno v:
Journal of medicinal chemistry. 63(14)
Utrophin modulation is a promising therapeutic strategy for Duchenne muscular dystrophy (DMD), which should be applicable to all patient populations. Following on from ezutromid, the first-generation utrophin modulator, we describe the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00bb576fc166748a4bd8bff6394c6d01
https://pubmed.ncbi.nlm.nih.gov/32551645
https://pubmed.ncbi.nlm.nih.gov/32551645
Autor:
Carole Eliane Andree Maillol, Richard Storer, Severine Danielle Poignant, Peter David Johnson, Renate van Well, Stephen Paul Wren, Jonathon M. Tinsley, Adam G. Lambert, Gary Nugent, Francis Xavier Wilson, Fraser J. Wilkes, Colin Richard Dorgan, Richard Vickers, Graham Michael Wynne, Cristina Lecci, Richard Joseph Pye, Olivier De Moor, Paul Damien Price
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4828-4831
Families of 2-arylbenzotriazoles and 2-arylindazoles that show positive effects in screens predictive of endogenous utrophin upregulation have been identified. Synthesis and structure-activity relationships are described leading to compounds with att
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88eb43eff53eb7246db535b17fe5fdd3
https://doi.org/10.1016/j.bmcl.2011.06.047
https://doi.org/10.1016/j.bmcl.2011.06.047
Autor:
Severine Danielle Poignant, Fraser J. Wilkes, Kay E. Davies, Adam G. Lambert, J Vile, P J Middleton, Francis Xavier Wilson, Peter David Johnson, Stephen Paul Wren, Carole Eliane Andree Maillol, Richard Storer, Chancellor, D Lawrence, Collin Richard Dorgan, Richard Vickers, Graham Michael Wynne, A Potter, Cristina Lecci, Paul Damien Price, Gary Nugent, O De Moor, Richard Joseph Pye, R van Well, Jonathon M. Tinsley
Publikováno v:
Journal of Medicinal Chemistry. 54:3241-3250
A series of novel 2-arylbenzoxazoles that upregulate the production of utrophin in murine H2K cells, as assessed using a luciferase reporter linked assay, have been identified. This compound class appears to hold considerable promise as a potential t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7d5e973d1a9516da52e0847a018b37
https://doi.org/10.1021/jm200135z
https://doi.org/10.1021/jm200135z
Autor:
Anna Iuliano, Cristina Lecci
Publikováno v:
Biomedical Chromatography. 19:439-446
A s-triazine scaffold bearing a free and a protected amino group was used for connecting two different chiral auxiliaries, whose enantiodiscriminating capabilities in enantioselective chromatography are well documented. A biselector system was synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a60bd24bee0e02b434aff3d20c03a8d
https://doi.org/10.1002/bmc.503
https://doi.org/10.1002/bmc.503
Publikováno v:
Tetrahedron: Asymmetry. 14:1345-1353
An s-triazine scaffold bearing a free and a protected amino group was synthesised and used for connecting two different and differently derivatised aminoacids. Two diastereoisomeric chiral systems were obtained and, once linked to silica gel, they we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a2b2c785ef55d83a01ddca42a59ef0a
https://doi.org/10.1016/s0957-4166(03)00203-9
https://doi.org/10.1016/s0957-4166(03)00203-9
Publikováno v:
ChemInform. 38
A double Heck reaction is the key step in a straightforward and versatile synthesis of nitrogen-rich macrocycles, including one which X-ray crystallography has revealed forms a tube-like structure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d5224e06f9dd1f1427a08d7ff1664e
https://doi.org/10.1002/chin.200713190
https://doi.org/10.1002/chin.200713190
Autor:
Susan E. Gibson, Cristina Lecci
Publikováno v:
ChemInform. 37
The synthesis, structure, and physical properties of macrocycles have fascinated chemists for many years. Their inherent properties make them useful in areas as diverse as ion transport across membranes, development of new antibiotics, and catalysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17c5f3c061c5bdd4700fbdab8dfd12da
https://doi.org/10.1002/chin.200620254
https://doi.org/10.1002/chin.200620254
Autor:
Susan E. Gibson, Cristina Lecci
Publikováno v:
Angewandte Chemie; Feb2006, Vol. 118 Issue 9, p1392-1405, 14p