Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Cristina Iclozan"'
Autor:
Nadine Nelson, Karoly Szekeres, Cristina Iclozan, Ivannie Ortiz Rivera, Andrew McGill, Gbemisola Johnson, Onyekachi Nwogu, Tomar Ghansah
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170197 (2017)
Pancreatic cancer (PC) evades immune destruction by favoring the development of regulatory T cells (Tregs) that inhibit effector T cells. The transcription factor Ikaros is critical for lymphocyte development, especially T cells. We have previously s
Externí odkaz:
https://doaj.org/article/f422de9d25b14847933d98db26bac17a
Autor:
Dmitry I. Gabrilovich, Ji-Hyun Lee, Bhupendra Rawal, Karen T. Liby, Michael B. Sporn, Scott Antonia, Mayer Fishman, Carlos R. Becerra, Colin Meyer, Matthew J. Cotter, Lily Lu, Cristina Iclozan, Hannah Weber, Je-In Youn, Srinivas Nagaraj
Supplementary Data from Anti-inflammatory Triterpenoid Blocks Immune Suppressive Function of MDSCs and Improves Immune Response in Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf02a6b966399f455c3be3999b58867
https://doi.org/10.1158/1078-0432.22442984
https://doi.org/10.1158/1078-0432.22442984
Autor:
Dmitry I. Gabrilovich, Ji-Hyun Lee, Bhupendra Rawal, Karen T. Liby, Michael B. Sporn, Scott Antonia, Mayer Fishman, Carlos R. Becerra, Colin Meyer, Matthew J. Cotter, Lily Lu, Cristina Iclozan, Hannah Weber, Je-In Youn, Srinivas Nagaraj
Purpose: Myeloid-derived suppressor cells (MDSC) are one of the major factors responsible for immune suppression in cancer. Therefore, it would be important to identify effective therapeutic means to modulate these cells.Experimental Design: We evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754fcf863b7be5a65ae611d96ca7c4a6
https://doi.org/10.1158/1078-0432.c.6519602.v1
https://doi.org/10.1158/1078-0432.c.6519602.v1
Autor:
Scott J. Antonia, Robert W. Engelman, Sungjune Kim, Min Liu, Jiqiang Yao, Anders Berglund, John M. Koomen, James J. Mulé, Ben C. Creelan, Min-Hsuan Wang, Nayoung Kim, Bin Fang, Lin Zhang, Jose R. Conejo-Garcia, Cristina Iclozan, Imene Hamaidi, Sean Yoder
Publikováno v:
Regular and young investigator award abstracts.
Background The majority of cancer patients remain refractory to existing cancer immunotherapies. Despite the growing evidence that dysregulated metabolism contributes to the exhaustion of tumor-infiltrating T lymphocytes (TILs) and the loss of their
Autor:
Ben C. Creelan, Lin Zhang, Nayoung Kim, Anders Berglund, John M. Koomen, Scott J. Antonia, Sungjune Kim, Sean J. Yoder, Robert W. Engelman, Jose R. Conejo-Garcia, Jiqiang Yao, Min Hsuan Wang, James J. Mulé, Imene Hamaidi, Min Liu, Bin Fang, Cristina Iclozan
Publikováno v:
Cancer Research. 81:1635-1635
Background: The majority of cancer patients remain refractory to existing cancer immunotherapies. Despite the growing evidence that dysregulated metabolism contributes to the exhaustion of tumor-infiltrating T lymphocytes (TILs) and the loss of their
Autor:
Min-Hsuan Wang, Ben C. Creelan, Lin Zhang, Cristina Iclozan, Bin Fang, Imene Hamaidi, Robert W. Engelman, Min Liu, Nayoung Kim, Anders Berglund, Scott J. Antonia, James J. Mulé, Sungjune Kim, Sean J. Yoder, Jose R. Conejo-Garcia, John M. Koomen, Jiqiang Yao
Publikováno v:
Cell Metab
Summary Dysregulated metabolism is a key driver of maladaptive tumor-reactive T lymphocytes within the tumor microenvironment. Actionable targets that rescue the effector activity of antitumor T cells remain elusive. Here, we report that the Sirtuin-
Publikováno v:
Cancer Immunology, Immunotherapy. 62:909-918
Myeloid-derived suppressor cells (MDSC) are one of the major factors limiting the efficacy of immune therapy. In a clinical trial of patients with extensive stage small cell lung cancer (SCLC), we tested the possibility that targeting MDSC can improv
Autor:
Nadine Nelson, Ivannie Ortiz Rivera, Tomar Ghansah, Gbemisola Johnson, Onyekachi Nwogu, Andrew R. McGill, Cristina Iclozan, Karoly Szekeres
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 2, p e0170197 (2017)
PLoS ONE, Vol 12, Iss 2, p e0170197 (2017)
Pancreatic cancer (PC) evades immune destruction by favoring the development of regulatory T cells (Tregs) that inhibit effector T cells. The transcription factor Ikaros is critical for lymphocyte development, especially T cells. We have previously s
Autor:
David Cheong, G. Douglas Letson, Brianna Lenox, Cristina Iclozan, Ricardo J. Gonzalez, Claudia Berman, Steven E. Finkelstein, Rupal Ramakrishnan, Scott J. Antonia, Vernon K. Sondak, David Noyes, Jamil Ahmed, William J. Janssen, Dmitry I. Gabrilovich, Jonathan S. Zager, Randy V. Heysek, Marilyn M. Bui, Matthew J. Cotter
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 82:924-932
Purpose The goal of this study was to determine the effect of combination of intratumoral administration of dendritic cells (DC) and fractionated external beam radiation (EBRT) on tumor-specific immune responses in patients with soft-tissue sarcoma (
Autor:
Carlos Becerra, Dmitry I. Gabrilovich, Mayer Fishman, Michael B. Sporn, Ji-Hyun Lee, Je In Youn, Lily Lu, Bhupendra Rawal, Hannah Weber, Karen T. Liby, Scott J. Antonia, Matthew J. Cotter, Colin J. Meyer, Srinivas Nagaraj, Cristina Iclozan
Publikováno v:
Clinical Cancer Research. 16:1812-1823
Purpose: Myeloid-derived suppressor cells (MDSC) are one of the major factors responsible for immune suppression in cancer. Therefore, it would be important to identify effective therapeutic means to modulate these cells. Experimental Design: We eval