Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Cristina Gardelli"'
Autor:
Simon T. Barry, Stephen E. Fawell, Teresa Klinowska, Susan E. Critchlow, Cristina Gardelli, Pablo Morentin Gutierrez, Michele Moschetta, Maneesh Singh, Danielle Carroll, Neha Wali, Antonio Ramos-Montoya, Yanjun Wang, Theresa A. Proia, Sigourney Bell, Adina M. Hughes, Anna M.L. Coenen-Stass, Matthew King, Molly A. Taylor, Larissa S. Carnevalli
Suppressive myeloid cells mediate resistance to immune checkpoint blockade. PI3Kγ inhibition can target suppressive macrophages, and enhance efficacy of immune checkpoint inhibitors. However, how PI3Kγ inhibitors function in different tumor microen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5db27890affeab7375808ed1468dea
https://doi.org/10.1158/1535-7163.c.6543334
https://doi.org/10.1158/1535-7163.c.6543334
Autor:
Simon T. Barry, Stephen E. Fawell, Teresa Klinowska, Susan E. Critchlow, Cristina Gardelli, Pablo Morentin Gutierrez, Michele Moschetta, Maneesh Singh, Danielle Carroll, Neha Wali, Antonio Ramos-Montoya, Yanjun Wang, Theresa A. Proia, Sigourney Bell, Adina M. Hughes, Anna M.L. Coenen-Stass, Matthew King, Molly A. Taylor, Larissa S. Carnevalli
Supplementary Figure 1. Pharmacokinetic (PK) properties of AZD3458 in mouse. Supplementary Figure 2. In vivo pharmacodynamic properties of AZD3458 in mouse neutrophils. Supp Fig 3. PI3K-�/mTOR pathway regulates expression of IL-10/IL-12 via LPS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948d7693e031fd14364c926a362ec350
https://doi.org/10.1158/1535-7163.22522333.v1
https://doi.org/10.1158/1535-7163.22522333.v1
Autor:
Simon T. Barry, Stephen E. Fawell, Teresa Klinowska, Susan E. Critchlow, Cristina Gardelli, Pablo Morentin Gutierrez, Michele Moschetta, Maneesh Singh, Danielle Carroll, Neha Wali, Antonio Ramos-Montoya, Yanjun Wang, Theresa A. Proia, Sigourney Bell, Adina M. Hughes, Anna M.L. Coenen-Stass, Matthew King, Molly A. Taylor, Larissa S. Carnevalli
Supplementary Materials and Methods. Suplementary Table 1. Tumor Immuno-phenotyping. Suplementary Table 2. Flow cytometry panels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e4df3e39a49aa5d8ff897330704dc2
https://doi.org/10.1158/1535-7163.22522330
https://doi.org/10.1158/1535-7163.22522330
Autor:
Ulf Sivars, Richard J. Lewis, Moya Caffrey, Leif Hultin, Antonio Llinas, Karin Gedda, Peter Hansen, Asim K. Ray, Ulf Andersson, Sara Lundqvist, Hiroki Wada, Lisa Jinton, Tina Jellesmark Jensen, Igor L. Shamovsky, Cristina Gardelli, Stina Sjödin, Nina Krutrök, Cooper Martin, Paul S. Jansson
Publikováno v:
Journal of Medicinal Chemistry. 63:9705-9730
Muscle atrophy and cachexia are common comorbidities among patients suffering from cancer, chronic obstructive pulmonary disease, and several other chronic diseases. The peptide hormone ghrelin exerts pleiotropic effects including the stimulation of
Autor:
Yanjun Wang, Sigourney Bell, A. Hughes, Theresa Proia, Neha Wali, Pablo Morentin Gutierrez, Matthew A. King, Larissa S. Carnevalli, Molly A. Taylor, Danielle Carroll, Michele Moschetta, Maneesh Singh, Antonio Ramos-Montoya, Cristina Gardelli, Stephen Fawell, Simon T. Barry, Anna M. L. Coenen-Stass, Teresa Klinowska, Susan E. Critchlow
Publikováno v:
Molecular cancer therapeutics. 20(6)
Suppressive myeloid cells mediate resistance to immune checkpoint blockade. PI3Kγ inhibition can target suppressive macrophages, and enhance efficacy of immune checkpoint inhibitors. However, how PI3Kγ inhibitors function in different tumor microen
Publikováno v:
Organic Process Research & Development. 22:1174-1187
A linear 14-step sequence was developed for the synthesis of an oxaspirocyclic cyclopentane-based candidate drug 1 containing four chiral centers. Compared with the first-generation synthesis with an overall yield of 0.7%, which also included several
Autor:
Kostas Karabelas, Ulf Andersson, Lisa Jinton, Ulf Sivars, Leif Hultin, Joakim Larsson, Cristina Gardelli, Brith Leidvik, Karin Gedda, Marie Rydén Landergren, Igor L. Shamovsky, Hiroki Wada, Kristina Stenvall, Asim K. Ray, Moya Caffrey, Hitesh J. Sanganee, Joakim Tholander, Antonio Llinas
Publikováno v:
Journal of Medicinal Chemistry. 61:5974-5987
Cachexia and muscle wasting are very common among patients suffering from cancer, chronic obstructive pulmonary disease, and other chronic diseases. Ghrelin stimulates growth hormone secretion via the ghrelin receptor, which subsequently leads to inc
Autor:
Nils Pemberton, Cristina Gardelli, Jens Petersen, Neil S. Holden, Helena Lindmark, Pavol Zlatoidsky, Sandra Rodrigo Blomqvist, Annika Westin Eriksson, Rhona J. Cox, Linda Öster, Christian Tyrchan, Susanne Arlbrandt, Sarah Lever, Perry Matthew, Bold Peter, Mickael Mogemark, Matthew F. Thomas, A. Monica Norberg, Kostas Karabelas, Johan Karlsson, Xueshan Li
Publikováno v:
'Journal of Medicinal Chemistry ', vol: 61, pages: 5435-5441 (2018)
In this paper, we describe the discovery and optimization of a new chemotype of isoform selective PI3Kγ inhibitors. Starting from an HTS hit, potency and physicochemical properties could be improved to give compounds such as 15, which is a potent an
Autor:
Danielle Carrol, Antonio Ramos Montoya, Cristina Gardelli, Larissa S. Carnevalli, Simon T. Barry, A. Hughes, Teresa Klinowska, Michele Moschetta, Matthew A. King, Molly A. Taylor, Pablo Morentin Gutierrez
Publikováno v:
Cancer Research. 79:100-100
The PI3Kγ isoform is a key regulator of immune cell proliferation, survival, migration and activation. PI3Kγ inhibitors have the potential to treat a variety of diseases including respiratory, inflammatory, metabolic disorders and cancer. In the co
Autor:
Michael Rowley, Cristina Gardelli, Vincent Brett Cooper, Vincenzo Pucci, Frank Narjes, Claudio Giuliano, Pearce Gareth Edward Stephen, Fabrizio Fiore, Edith Monteagudo, Ralph Laufer, Simona Cianetti, Barbara Attenni
Publikováno v:
Drug Delivery. 17:214-222
The purpose of this study was to investigate the in vivo absorption enhancement of a nucleoside (phosphoramidate prodrug of 2'-methyl-cytidine) anti-viral agent of proven efficacy by means of intestinal permeation enhancers. Natural nucleosides are h