Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Cristina Frusteri"'
Autor:
Antonella Rigo, Tiziana Vaisitti, Carlo Laudanna, Eleonora Terrabuio, Matilde Micillo, Cristina Frusteri, Beatrice D’Ulivo, Flavia Merigo, Andrea Sbarbati, Kevin Mellert, Peter Möeller, Alessio Montresor, Arianna Di Napoli, Roberto Cirombella, Elena Butturini, Massimo Massaia, Gabriela Constantin, Fabrizio Vinante, Silvia Deaglio, Isacco Ferrarini
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-15 (2024)
Abstract Richter’s syndrome (RS) is the transformation of chronic lymphocytic leukemia (CLL) into a high-grade B-cell malignancy. Molecular and functional studies have pointed out that CLL cells are close to the apoptotic threshold and dependent on
Externí odkaz:
https://doaj.org/article/611bace9a8024c29978a49892c3b1f93
Autor:
Annalisa Adamo, Cristina Frusteri, Sara Pilotto, Simone Caligola, Lorenzo Belluomini, Ornella Poffe, Luca Giacobazzi, Silvia Dusi, Chiara Musiu, Yushu Hu, Tian Wang, Davide Rizzini, Antonio Vella, Stefania Canè, Giulia Sartori, Jessica Insolda, Marco Sposito, Ursula Cesta Incani, Carmine Carbone, Geny Piro, Francesca Pettinella, Fang Qi, Dali Wang, Silvia Sartoris, Francesco De Sanctis, Patrizia Scapini, Stefano Dusi, Marco Antonio Cassatella, Emilio Bria, Michele Milella, Vincenzo Bronte, Stefano Ugel
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTCancer cells favor the generation of myeloid cells with immunosuppressive and inflammatory features, including myeloid-derived suppressor cells (MDSCs), which support tumor progression. The anti-apoptotic molecule, cellular FLICE (FADD-like i
Externí odkaz:
https://doaj.org/article/5801fb8ef0cd4ae58a3140fe2943e55c
Autor:
Vincenzo Salemme, Mauro Vedelago, Alessandro Sarcinella, Federico Moietta, Alessio Piccolantonio, Enrico Moiso, Giorgia Centonze, Marta Manco, Andrea Guala, Alessia Lamolinara, Costanza Angelini, Alessandro Morellato, Dora Natalini, Raffaele Calogero, Danny Incarnato, Salvatore Oliviero, Laura Conti, Manuela Iezzi, Daniela Tosoni, Giovanni Bertalot, Stefano Freddi, Francesco A. Tucci, Francesco De Sanctis, Cristina Frusteri, Stefano Ugel, Vincenzo Bronte, Federica Cavallo, Paolo Provero, Marta Gai, Daniela Taverna, Emilia Turco, Salvatore Pece, Paola Defilippi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract The p140Cap adaptor protein is a tumor suppressor in breast cancer associated with a favorable prognosis. Here we highlight a function of p140Cap in orchestrating local and systemic tumor-extrinsic events that eventually result in inhibition
Externí odkaz:
https://doaj.org/article/6ef08fc8d1c74047923f8519dfa3b883
Autor:
Giulio Fracasso, Elisabetta Falvo, Giada Tisci, Gianluca Sala, Gianni Colotti, Sara Cingarlini, Claudia Tito, Sandra Bibbo, Cristina Frusteri, Elisa Tremante, Elena Giordani, Patrizio Giacomini, Pierpaolo Ceci
Publikováno v:
Heliyon, Vol 9, Iss 10, Pp e20770- (2023)
Background: Cancer is still among the leading causes of death all over the world. Improving chemotherapy and minimizing associated toxicities are major unmet medical needs. Recently, we provided a preliminary preclinical evaluation of a human ferriti
Externí odkaz:
https://doaj.org/article/25b7226ed4974a9dbaadcf2acec008ae
Autor:
Matteo Fassan, David A Tuveson, Claudio Bassi, Salvatore Paiella, Stefano Ugel, Francesco De Sanctis, Vincenzo Bronte, Roberto Salvia, Lorenzo Piemonti, Stefania Canè, Rita Teresa Lawlor, Vincenzo Corbo, Alessia Lamolinara, Federico Boschi, Chiara Musiu, Simone Caligola, Rosalinda Trovato, Alessandra Fiore, Cristina Frusteri, Cristina Anselmi, Ornella Poffe, Tiziana Cestari, Silvia Sartoris, Rosalba Giugno, Giulia Del Rosario, Barbara Zappacosta, Francesco Del Pizzo, Erica Dugnani, Emanuela Bottani, Ilaria Decimo, Youngkyu Park, Manuela Iezzi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/158bd16e6e4747a8942905e28c98f147
Autor:
Annalisa Adamo, Cristina Frusteri, Maria Teresa Pallotta, Tracey Pirali, Silvia Sartoris, Stefano Ugel
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Plasticity and adaptation to environmental stress are the main features that tumor and immune system share. Except for intrinsic and high-defined properties, cancer and immune cells need to overcome the opponent’s defenses by activating more effect
Externí odkaz:
https://doaj.org/article/e4064987c7784fc9b2930cd29054270f
Autor:
Mads Hald Andersen, Vincenzo Bronte, Ayako Wakatsuki Pedersen, Daniel Hargbøll Madsen, Mai-Britt Zocca, Manuela Iezzi, Cristina Frusteri, Francesco De Sanctis, Annalisa Adamo, Marion Chapellier, Katharina Kopp, Evelina Martinenaite, Stine Emilie Weis-Banke, Maria Perez-Penco, Marco Carretta, Mie Linder Hübbe, Stefano Ugel, Mia Aaboe Jørgensen
Expression of the L-arginine catabolizing enzyme arginase 1 (ARG1) is a central immunosuppressive mechanism mediated by tumor-educated myeloid cells. Increased activity of ARG1 promotes the formation of an immunosuppressive microenvironment and leads
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666a35b5cf78d8cf2f4835377ed3e14d
https://doi.org/10.1158/2326-6066.c.6550574
https://doi.org/10.1158/2326-6066.c.6550574
Autor:
Francesca Lupo, Francesco Pezzini, Elena Fiorini, Annalisa Adamo, Lisa Veghini, Michele Bevere, Cristina Frusteri, Pietro Delfino, Sabrina D’Agosto, Silvia Andreani, Geny Piro, Antonia Malinova, Francesco De Sanctis, Davide Pasini, Rita T. Lawlor, Chang-il Hwang, Carmine Carbone, Ivano Amelio, Peter Bailey, Vincenzo Bronte, David Tuveson, Aldo Scarpa, Stefano Ugel, Vincenzo Corbo
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with few available therapeutic options. Two transcriptional cancer cell states have been consistently reported in PDAC, with the basal-like/squamous phenotype displaying a more aggressive bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6039dd8c6af07f1f4302630d17bce71b
https://doi.org/10.1101/2023.02.25.529923
https://doi.org/10.1101/2023.02.25.529923
Autor:
Francesco De Sanctis, Alessia Lamolinara, Federico Boschi, Chiara Musiu, Simone Caligola, Rosalinda Trovato, Alessandra Fiore, Cristina Frusteri, Cristina Anselmi, Ornella Poffe, Tiziana Cestari, Stefania Canè, Silvia Sartoris, Rosalba Giugno, Giulia Del Rosario, Barbara Zappacosta, Francesco Del Pizzo, Matteo Fassan, Erica Dugnani, Lorenzo Piemonti, Emanuela Bottani, Ilaria Decimo, Salvatore Paiella, Roberto Salvia, Rita Teresa Lawlor, Vincenzo Corbo, Youngkyu Park, David A Tuveson, Claudio Bassi, Aldo Scarpa, Manuela Iezzi, Stefano Ugel, Vincenzo Bronte
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
BackgroundPancreatic ductal adenocarcinoma (PDAC) is one of the deadliest tumors owing to its robust desmoplasia, low immunogenicity, and recruitment of cancer-conditioned, immunoregulatory myeloid cells. These features strongly limit the success of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661325dd16670be67fc4f48b109f0734
http://hdl.handle.net/11577/3421154
http://hdl.handle.net/11577/3421154
Autor:
Manuela Iezzi, Katia Donadello, Zheng-Li Shi, Stefano Ugel, Stefania Canè, Ying Chen, Marco Chilosi, Ido Amit, Peter J. Murray, Vincenzo Bronte, Francesca Hofer, Enrico Polati, Evelina Tacconelli, Piera Amelia Iezzi, Andrea Capece, Francesco De Sanctis, Alessandra Fiore, Francesco Domenico Del Pizzo, Leonardo Gottin, Serena Zilio, Silvio Bicciato, Chiara Musiu, Simone Caligola, Roza Maria Barouni, Alessia Lamolinara, Domenico Angelucci, Ildo Polidoro, Paolo Serafini, Cristina Frusteri, Andrea Grilli, Annalisa Adamo, Domenico Girelli
Publikováno v:
Cell Death and Differentiation
Inflammatory responses rapidly detect pathogen invasion and mount a regulated reaction. However, dysregulated anti-pathogen immune responses can provoke life-threatening inflammatory pathologies collectively known as cytokine release syndrome (CRS),