Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Cristina Fernandez-Valle"'
Autor:
Eric Nisenbaum MD, Carly Misztal, Mikhaylo Szczupak MD, Torin Thielhelm, Stefanie Peña MD, Christine Mei MD, Stefania Goncalves MD, Olena Bracho, Ruixuan Ma MS, Michael E. Ivan MD, Jacques Morcos MD, Fred Telischi MD, Xue-Zhong Liu MD, PhD, Cristina Fernandez-Valle PhD, Christine T. Dinh MD
Publikováno v:
OTO Open, Vol 5 (2021)
Objective (1) Characterize the distribution of M1 and M2 macrophages in vestibular schwannomas by hearing status. (2) Develop assays to assess monocyte migration and macrophage polarization in cocultures with vestibular schwannoma cells. Study Design
Externí odkaz:
https://doaj.org/article/98cd671eb85e4952aaf95eab47c96934
Autor:
Aida Nourbakhsh, Nicholas C. Gosstola, Cristina Fernandez-Valle, Derek M. Dykxhoorn, Xue Zhong Liu
Publikováno v:
Stem Cell Research, Vol 55, Iss , Pp 102474- (2021)
The UMi031-A-2 hiPSC line contains a CRISPR-induced homozygous, Neurofibromatosis Type 2 (NF2) mutation (L64P (CTG > CCG)) in the NF2 gene that encodes a merlin tumor suppressor. This line was generated from an unaffected iPSC line using CRISPR techn
Externí odkaz:
https://doaj.org/article/4dec461c3db043138b78ad4f9361b379
Autor:
Long-Sheng Chang, Janet L Oblinger, Abbi E Smith, Marc Ferrer, Steven P Angus, Eric Hawley, Alejandra M Petrilli, Roberta L Beauchamp, Lars Björn Riecken, Serkan Erdin, Ming Poi, Jie Huang, Waylan K Bessler, Xiaohu Zhang, Rajarshi Guha, Craig Thomas, Sarah S Burns, Thomas S K Gilbert, Li Jiang, Xiaohong Li, Qingbo Lu, Jin Yuan, Yongzheng He, Shelley A H Dixon, Andrea Masters, David R Jones, Charles W Yates, Stephen J Haggarty, Salvatore La Rosa, D Bradley Welling, Anat O Stemmer-Rachamimov, Scott R Plotkin, James F Gusella, Justin Guinney, Helen Morrison, Vijaya Ramesh, Cristina Fernandez-Valle, Gary L Johnson, Jaishri O Blakeley, D Wade Clapp, Synodos for NF2 Consortium
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0252048 (2021)
Neurofibromatosis Type 2 (NF2) is an autosomal dominant genetic syndrome caused by mutations in the NF2 tumor suppressor gene resulting in multiple schwannomas and meningiomas. There are no FDA approved therapies for these tumors and their relentless
Externí odkaz:
https://doaj.org/article/d5cdd322a442449ebaffcbfad82ea6a3
Autor:
Synodos for NF2 Consortium, Robert Allaway, Steve P Angus, Roberta L Beauchamp, Jaishri O Blakeley, Marga Bott, Sarah S Burns, Annemarie Carlstedt, Long-Sheng Chang, Xin Chen, D Wade Clapp, Patrick A Desouza, Serkan Erdin, Cristina Fernandez-Valle, Justin Guinney, James F Gusella, Stephen J Haggarty, Gary L Johnson, Salvatore La Rosa, Helen Morrison, Alejandra M Petrilli, Scott R Plotkin, Abhishek Pratap, Vijaya Ramesh, Noah Sciaky, Anat Stemmer-Rachamimov, Tim J Stuhlmiller, Michael E Talkowski, D Bradley Welling, Charles W Yates, Jon S Zawistowski, Wen-Ning Zhao
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197350 (2018)
Neurofibromatosis 2 (NF2) is a rare tumor suppressor syndrome that manifests with multiple schwannomas and meningiomas. There are no effective drug therapies for these benign tumors and conventional therapies have limited efficacy. Various model syst
Externí odkaz:
https://doaj.org/article/9827869b05b5455bb1789d9f8c1987f8
Autor:
Maria Elisa Manetti, Sandra Geden, Marga Bott, Nicklaus Sparrow, Stephen Lambert, Cristina Fernandez-Valle
Publikováno v:
Biology Open, Vol 1, Iss 10, Pp 949-957 (2012)
Summary The NF2 gene encodes a tumor suppressor protein known as merlin or schwannomin whose loss of function causes Neurofibromatosis Type 2 (NF2). NF2 is characterized by the development of benign tumors, predominantly schwannomas, in the periphera
Externí odkaz:
https://doaj.org/article/9b1e6c09fe864090b70d2b302239e814
Autor:
Julianne, Huegel, Christine T, Dinh, Maria, Martinelli, Olena, Bracho, Rosa, Rosario, Haley, Hardin, Michael, Estivill, Anthony, Griswold, Sakir, Gultekin, Xue-Zhong, Liu, Cristina, Fernandez-Valle
Publikováno v:
Oncotarget. 13:890-904
Neurofibromatosis Type 2 (NF2) is a rare tumor disorder caused by pathogenic variants of the merlin tumor suppressor encoded by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a30b205060119e641bddbe7d137026
https://doi.org/10.18632/oncotarget.28254
https://doi.org/10.18632/oncotarget.28254
Autor:
Cristina Fernandez-Valle, Maria Clara Franco, Long-Sheng Chang, Fred F. Telischi, Xue Zhong Liu, Alicja J. Copik, Julia N. Soulakova, Rulong Shen, Rahul Mittal, Denise Yan, Olena Bracho, Christine T. Dinh, Sarah S. Burns, Stephani Klingeman Plati, Marisa A. Fuse
Neurofibromatosis type 2 (NF2) is a nervous system tumor disorder caused by inactivation of the merlin tumor suppressor encoded by the NF2 gene. Bilateral vestibular schwannomas are a diagnostic hallmark of NF2. Mainstream treatment options for NF2-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2082edda612e31101b4c151aaef003
https://doi.org/10.1158/1535-7163.c.6538786.v1
https://doi.org/10.1158/1535-7163.c.6538786.v1
Autor:
Cristina Fernandez-Valle, Maria Clara Franco, Long-Sheng Chang, Fred F. Telischi, Xue Zhong Liu, Alicja J. Copik, Julia N. Soulakova, Rulong Shen, Rahul Mittal, Denise Yan, Olena Bracho, Christine T. Dinh, Sarah S. Burns, Stephani Klingeman Plati, Marisa A. Fuse
All supplementary data - four figures and supplementary methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89058016f44c9a449071bff09a3eb168
https://doi.org/10.1158/1535-7163.22507780.v1
https://doi.org/10.1158/1535-7163.22507780.v1
Autor:
Torin P. Thielhelm, Aida Nourbakhsh, Scott M. Welford, Eric A. Mellon, Olena Bracho, Michael E. Ivan, Fred Telischi, Cristina Fernandez‐Valle, Christine T. Dinh
Publikováno v:
Otolaryngology–Head and Neck Surgery. 167:860-868
To describe the RAD51 response (DNA repair) to radiation-induced DNA damage in patient-derived vestibular schwannoma (VS) cells and investigate the utility of RAD51 inhibitor (RI-1) in enhancing radiation toxicity.Basic and translational science.Tert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09604dc02ca02fc9851ab0914f2d56c0
https://doi.org/10.1177/01945998221083506
https://doi.org/10.1177/01945998221083506
Autor:
Torin P Thielhelm, Cristina Fernandez-Valle, Olena Bracho, Christine T. Dinh, Michael E. Ivan, Clifford S. Brown, Stefania Goncalves, Eric A. Mellon, Fred F. Telischi, Michael Estivill, Scott M. Welford, Jacques J. Morcos
Publikováno v:
Otol Neurotol
HYPOTHESIS: Vestibular Schwannoma (VS) can avoid cell death following radiation injury by entering cell cycle arrest and activating RAD51-related DNA repair. BACKGROUND: Although the radiobiology of various cancers is well-studied, the radiobiologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00022775f0f80f082b39b4455f90871c
https://doi.org/10.1097/mao.0000000000003322
https://doi.org/10.1097/mao.0000000000003322