Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Cristina Fernández-Valle"'
Autor:
Isabelle E. Logan, Kyle T. Nguyen, Tilottama Chatterjee, Bhagyashree Manivannan, Ngozi P. Paul, Sharon R. Kim, Evelyn M. Sixta, Lydia P. Bastian, Carrie Marean-Reardon, Matthias A. Karajannis, Cristina Fernández-Valle, Alvaro G. Estevez, Maria Clara Franco
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103249- (2024)
Tumors develop in an oxidative environment characterized by peroxynitrite production and downstream protein tyrosine (Y) nitration. We showed that tyrosine nitration supports schwannoma cell proliferation and regulates cell metabolism in the inherita
Externí odkaz:
https://doaj.org/article/a8cffb2357254133802d9cb6592576c9
Autor:
Isabelle E. Logan, Sharon Kim, Kyle Nguyen, Evelyn Sixta, Lydia Bastian, Cristina Fernández‐Valle, Alvaro Estevez, Maria Franco
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::600aaa11e21acffe2ab0a994278c0983
https://doi.org/10.1096/fasebj.2022.36.s1.r4036
https://doi.org/10.1096/fasebj.2022.36.s1.r4036
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1739
Schwannomas are benign nerve tumors that occur sporadically in the general population and in those with neurofibromatosis type 2 (NF2), a tumor predisposition genetic disorder. NF2-associated schwannomas and most sporadic schwannomas are caused by in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::761359cbbd3c264c19e3894c4d53fa93
https://pubmed.ncbi.nlm.nih.gov/29546707
https://pubmed.ncbi.nlm.nih.gov/29546707
Autor:
Eric Nisenbaum MD, Carly Misztal, Mikhaylo Szczupak MD, Torin Thielhelm, Stefanie Peña MD, Christine Mei MD, Stefania Goncalves MD, Olena Bracho, Ruixuan Ma MS, Michael E. Ivan MD, Jacques Morcos MD, Fred Telischi MD, Xue-Zhong Liu MD, PhD, Cristina Fernandez-Valle PhD, Christine T. Dinh MD
Publikováno v:
OTO Open, Vol 5 (2021)
Objective (1) Characterize the distribution of M1 and M2 macrophages in vestibular schwannomas by hearing status. (2) Develop assays to assess monocyte migration and macrophage polarization in cocultures with vestibular schwannoma cells. Study Design
Externí odkaz:
https://doaj.org/article/98cd671eb85e4952aaf95eab47c96934
Autor:
Aida Nourbakhsh, Nicholas C. Gosstola, Cristina Fernandez-Valle, Derek M. Dykxhoorn, Xue Zhong Liu
Publikováno v:
Stem Cell Research, Vol 55, Iss , Pp 102474- (2021)
The UMi031-A-2 hiPSC line contains a CRISPR-induced homozygous, Neurofibromatosis Type 2 (NF2) mutation (L64P (CTG > CCG)) in the NF2 gene that encodes a merlin tumor suppressor. This line was generated from an unaffected iPSC line using CRISPR techn
Externí odkaz:
https://doaj.org/article/4dec461c3db043138b78ad4f9361b379
Autor:
Long-Sheng Chang, Janet L Oblinger, Abbi E Smith, Marc Ferrer, Steven P Angus, Eric Hawley, Alejandra M Petrilli, Roberta L Beauchamp, Lars Björn Riecken, Serkan Erdin, Ming Poi, Jie Huang, Waylan K Bessler, Xiaohu Zhang, Rajarshi Guha, Craig Thomas, Sarah S Burns, Thomas S K Gilbert, Li Jiang, Xiaohong Li, Qingbo Lu, Jin Yuan, Yongzheng He, Shelley A H Dixon, Andrea Masters, David R Jones, Charles W Yates, Stephen J Haggarty, Salvatore La Rosa, D Bradley Welling, Anat O Stemmer-Rachamimov, Scott R Plotkin, James F Gusella, Justin Guinney, Helen Morrison, Vijaya Ramesh, Cristina Fernandez-Valle, Gary L Johnson, Jaishri O Blakeley, D Wade Clapp, Synodos for NF2 Consortium
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0252048 (2021)
Neurofibromatosis Type 2 (NF2) is an autosomal dominant genetic syndrome caused by mutations in the NF2 tumor suppressor gene resulting in multiple schwannomas and meningiomas. There are no FDA approved therapies for these tumors and their relentless
Externí odkaz:
https://doaj.org/article/d5cdd322a442449ebaffcbfad82ea6a3
Autor:
Synodos for NF2 Consortium, Robert Allaway, Steve P Angus, Roberta L Beauchamp, Jaishri O Blakeley, Marga Bott, Sarah S Burns, Annemarie Carlstedt, Long-Sheng Chang, Xin Chen, D Wade Clapp, Patrick A Desouza, Serkan Erdin, Cristina Fernandez-Valle, Justin Guinney, James F Gusella, Stephen J Haggarty, Gary L Johnson, Salvatore La Rosa, Helen Morrison, Alejandra M Petrilli, Scott R Plotkin, Abhishek Pratap, Vijaya Ramesh, Noah Sciaky, Anat Stemmer-Rachamimov, Tim J Stuhlmiller, Michael E Talkowski, D Bradley Welling, Charles W Yates, Jon S Zawistowski, Wen-Ning Zhao
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197350 (2018)
Neurofibromatosis 2 (NF2) is a rare tumor suppressor syndrome that manifests with multiple schwannomas and meningiomas. There are no effective drug therapies for these benign tumors and conventional therapies have limited efficacy. Various model syst
Externí odkaz:
https://doaj.org/article/9827869b05b5455bb1789d9f8c1987f8
Autor:
Maria Elisa Manetti, Sandra Geden, Marga Bott, Nicklaus Sparrow, Stephen Lambert, Cristina Fernandez-Valle
Publikováno v:
Biology Open, Vol 1, Iss 10, Pp 949-957 (2012)
Summary The NF2 gene encodes a tumor suppressor protein known as merlin or schwannomin whose loss of function causes Neurofibromatosis Type 2 (NF2). NF2 is characterized by the development of benign tumors, predominantly schwannomas, in the periphera
Externí odkaz:
https://doaj.org/article/9b1e6c09fe864090b70d2b302239e814