Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19

Autor: Jesús F. Bermejo-Martin, Milagros González-Rivera, Raquel Almansa, Dariela Micheloud, Ana P. Tedim, Marta Domínguez-Gil, Salvador Resino, Marta Martín-Fernández, Pablo Ryan Murua, Felipe Pérez-García, Luis Tamayo, Raúl Lopez-Izquierdo, Elena Bustamante, César Aldecoa, José Manuel Gómez, Jesús Rico-Feijoo, Antonio Orduña, Raúl Méndez, Isabel Fernández Natal, Gregoria Megías, Montserrat González-Estecha, Demetrio Carriedo, Cristina Doncel, Noelia Jorge, Alicia Ortega, Amanda de la Fuente, Félix del Campo, José Antonio Fernández-Ratero, Wysali Trapiello, Paula González-Jiménez, Guadalupe Ruiz, Alyson A. Kelvin, Ali Toloue Ostadgavahi, Ruth Oneizat, Luz María Ruiz, Iria Miguéns, Esther Gargallo, Ioana Muñoz, Sara Pelegrin, Silvia Martín, Pablo García Olivares, Jamil Antonio Cedeño, Tomás Ruiz Albi, Carolina Puertas, Jose Ángel Berezo, Gloria Renedo, Rubén Herrán, Juan Bustamante-Munguira, Pedro Enríquez, Ramón Cicuendez, Jesús Blanco, Jesica Abadia, Julia Gómez Barquero, Nuria Mamolar, Natalia Blanca-López, Luis Jorge Valdivia, Belén Fernández Caso, María Ángeles Mantecón, Anna Motos, Laia Fernandez-Barat, Ricard Ferrer, Ferrán Barbé, Antoni Torres, Rosario Menéndez, José María Eiros, David J. Kelvin

Publikováno v: Critical Care, Vol 24, Iss 1, Pp 1-13 (2020)

Abstract Background COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-19 is characterized by a dysregulated host response to this virus.

Externí odkaz: https://doaj.org/article/60fc039a753643adae89671cf2ace0f6

Regulation of cell wall synthesis by the clathrin light chain is essential for viability in Schizosaccharomyces pombe.

Autor: Nagore de León, Mohammad Reza Sharifmoghadam, Marta Hoya, M-Ángeles Curto, Cristina Doncel, M-Henar Valdivieso

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e71510 (2013)

The regulation of cell wall synthesis by the clathrin light chain has been addressed. Schizosaccharomyces pombe clc1Δ mutant was inviable in the absence of osmotic stabilization; when grown in sorbitol-supplemented medium clc1Δ cells grew slowly, f

Externí odkaz: https://doaj.org/article/546763bed0b640e9b8a9e0d0afdc6572

The integrity of the cytokinesis machinery under stress conditions requires the glucan synthase Bgs1p and its regulator Cfh3p.

Autor: Mohammad Reza Sharifmoghadam, M-Ángeles Curto, Marta Hoya, Nagore de León, Rebeca Martin-Garcia, Cristina Doncel, M-Henar Valdivieso

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e42726 (2012)

In yeast, cytokinesis requires coordination between nuclear division, acto-myosin ring contraction, and septum synthesis. We studied the role of the Schizosaccharomyces pombe Bgs1p and Cfh3p proteins during cytokinesis under stress conditions. Cfh3p

Externí odkaz: https://doaj.org/article/4dffc9ac2add46ba87c42cbc59592d67

Endothelial dysfunction is an early indicator of sepsis and neutrophil degranulation of septic shock in surgical patients

Autor: J.M. Calvo-Vecino, Luis Mario Vaquero-Roncero, Elisa Sanchez-Barrado, Raquel Almansa, Estefanía Gómez-Pesquera, Mario Lorenzo-López, Esther Zarca, Agustin Díaz-Alvarez, Marta Aragón, Carmen González-Sánchez, Marta Martín-Fernández, José Ignacio Gómez-Herreras, Jesús Rico-Feijoo, Eduardo Tamayo, C. Abad‐Molina, Cristina Doncel, Maria Carmen Esteban-Velasco, Alberto Ríos-Llorente, Esther Gómez-Sánchez, Silvia Martín, Jesus F. Bermejo-Martin, D. Álvarez, Cesar Aldecoa, Alicia Ortega, María Heredia-Rodríguez, Dolores Calvo, José María Rodríguez López, Luis Muñoz-Bellvís, David Andaluz-Ojeda, P. Ruiz-Granado

Publikováno v: BJS Open
BJS Open, Vol 4, Iss 3, Pp 524-534 (2020)
UVaDOC: Repositorio Documental de la Universidad de Valladolid
Universidad de Valladolid
UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname

Producción Científica
Background: Stratification of the severity of infection is currently based on the Sequential Organ Failure Assessment (SOFA) score, which is difficult to calculate outside the ICU. Biomarkers could help to stratify the se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382fd7a5cd8a5be564afb3aad9f97ab5
https://doi.org/10.1002/bjs5.50265

C-Reactive protein and SOFA score as early predictors of critical care requirement in patients with COVID-19 pneumonia in Spain

Autor: Luis Mario Vaquero-Roncero, Elisa Sánchez-Barrado, Daniel Escobar-Macias, Pilar Arribas-Pérez, Jose Ramón Gonzalez-Porras, Jesús F Bermejo-Martín, Cristina Doncel, JM Bastida, Azucena Hernández-Valero, Carolina Jambrina-García Montoto, José Sánchez-Crespo, Pablo Alonso-Hernández, Domingo Bustos-García, Antonio Rodríguez-Calvo, Gerardo Riesco-Galache, Raúl Alzibeíro, Alberto Hernández-Sánchez, Rocío Eiros, M Carmen Vargas, María Ángeles Martín, Teresa López, José Alfonso Sastre, José Carlos Garzón, Mar Fernández, Belén García, M Magdalena Muñoz, María Isabel Martínez, Gonzalo García, Agustín Díaz, Edgar Marcano, Víctor Sagredo-Meneses, Miguel Vicente Sánchez-Hernandez

BackgroundSome patients infected by SARS-CoV-2 in the recent pandemic have required critical care, becoming one of the main limitations of the health systems. Our objective has been to identify potential markers at admission predicting the need for c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2ab17febc34c41f251725d8eaaa8f3
https://doi.org/10.1101/2020.05.22.20110429