Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Cristina Delgado-Martin"'
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Akademický článek
CRLF2 rearrangement in Ph-like acute lymphoblastic leukemia predicts relative glucocorticoid resistance that is overcome with MEK or Akt inhibition.
Autor: Lauren K Meyer, Cristina Delgado-Martin, Shannon L Maude, Kevin M Shannon, David T Teachey, Michelle L Hermiston
Publikováno v: PLoS ONE, Vol 14, Iss 7, p e0220026 (2019)
Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is a genetically heterogeneous subtype of B-cell ALL characterized by chromosomal rearrangements and mutations that result in aberrant cytokine receptor and kinase signaling. I
Externí odkaz: https://doaj.org/article/9fff0adeacea48399c88f30fc0e09e1d
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3
Inhibition of the Sec61 translocon overcomes cytokine‐induced glucocorticoid resistance in T‐cell acute lymphoblastic leukaemia
Autor: Lauren K. Meyer, Cristina Delgado‐Martin, Phillip P. Sharp, Benjamin J. Huang, Dustin McMinn, Tiffaney L. Vincent, Theresa Ryan, Terzah M. Horton, Brent L. Wood, David T. Teachey, Jack Taunton, Christopher J. Kirk, Michelle L. Hermiston
Publikováno v: British Journal of Haematology. 198:137-141
Glucocorticoid (GC) resistance is a poor prognostic factor in T-cell acute lymphoblastic leukaemia (T-ALL). Interleukin-7 (IL-7) mediates GC resistance via GC-induced upregulation of IL-7 receptor (IL-7R) expression, leading to increased pro-survival
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162bb3ed2a4fd00d94a3096d7bf84715
https://doi.org/10.1111/bjh.18181
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5
Glucocorticoids paradoxically facilitate steroid resistance in T cell acute lymphoblastic leukemias and thymocytes
Autor: Anica M. Wandler, Benjamin J. Huang, Tiffaney Vincent, Michelle L. Hermiston, Aaron Hechmer, Brent L. Wood, Kevin Shannon, Lauren K. Meyer, Cristina Delgado-Martin, Terzah M. Horton, Adam B. Olshen, David T. Teachey, Paolo Fortina, Ritu Roy
Publikováno v: J Clin Invest
The Journal of clinical investigation, vol 130, iss 2
Glucocorticoids (GCs) are a central component of therapy for patients with T cell acute lymphoblastic leukemia (T-ALL), and although resistance to GCs is a strong negative prognostic indicator in T-ALL, the mechanisms of GC resistance remain poorly u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d78e24c2adb2d118232ebc5babcafc
https://europepmc.org/articles/PMC6994137/
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6
Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity
Autor: Tanaji T. Talele, Bhargav A. Patel, Xuwei Shao, Cristina Delgado-Martin, Morgan E. Diolaiti, John M. Pascal, Sietske T. Bakker, Uday Kiran Velagapudi, Alan Ashworth, Marie-France Langelier
Publikováno v: Journal of medicinal chemistry, vol 62, iss 11
J Med Chem
Poly(adenosine 5'-diphosphate-ribose) polymerase (PARP) inhibitors are a class of anticancer drugs that block the catalytic activity of PARP proteins. Optimization of our lead compound 1 (( Z)-2-benzylidene-3-oxo-2,3-dihydrobenzofuran-7-carboxamide;
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8138dd4966fc4a4c1af548135daa7b3
https://escholarship.org/uc/item/89s5g8dd
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7
CRLF2 rearrangement in Ph-like acute lymphoblastic leukemia predicts relative glucocorticoid resistance that is overcome with MEK or Akt inhibition
Autor: Shannon L. Maude, Cristina Delgado-Martin, David T. Teachey, Lauren K. Meyer, Kevin Shannon, Michelle L. Hermiston
Publikováno v: PLoS ONE, Vol 14, Iss 7, p e0220026 (2019)
PLoS ONE
PloS one, vol 14, iss 7
Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is a genetically heterogeneous subtype of B-cell ALL characterized by chromosomal rearrangements and mutations that result in aberrant cytokine receptor and kinase signaling. I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a681acd5bfbd7bc49f6930bc3245ee2e
https://doaj.org/article/9fff0adeacea48399c88f30fc0e09e1d
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9
High throughput flow cytometry identifies small molecule inhibitors for drug repurposing in T-ALL
Autor: Dominique Perez, Stephen P. Hunger, Alexandre Chigaev, Michelle L. Hermiston, Cristina Delgado-Martin, Travis A. Woods, Bruce S. Edwards, Ksenia Matlawska-Wasowska, Anna Waller, Nitesh D. Sharma, Stuart S. Winter, Mignon L. Loh, Larry A. Sklar, Christian K. Nickl
Publikováno v: SLAS discovery : advancing life sciences R & D, vol 23, iss 7
Kinase inhibitors have dramatically increased patient survival in a multitude of cancers, including hematological malignancies. However, kinase inhibitors have not yet been integrated into current clinical trials for patients with T-cell lineage acut
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d09a3fbd8cba1c062b5dc9a71ba3c1
https://europepmc.org/articles/PMC6292518/
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