Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Cristina D. Gaddie"'
Autor:
Geoffrey D. Keeler, Cristina D. Gaddie, Addelynn S. Sagadevan, Kevin G. Senior, Isabelle Côté, Michaela Rechdan, Daniel Min, David Mahan, Bianca Poma, Brad E. Hoffman
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 177-189 (2023)
In vivo induction of antigen (Ag)-specific regulatory T cells (Treg) is considered the holy grail of therapeutic strategies for restoring tolerance in autoimmunity. Unfortunately, in the autoimmune disease multiple sclerosis, an effective and durable
Externí odkaz:
https://doaj.org/article/27ce27000c494794b53f69c9f4ea3b9e
Autor:
Kevin G Senior, Isabelle Cote, Addelynn Sonia Sagadevan, Cristina D. Gaddie, Geoffrey D. Keeler, Daniel Min, Madisyn T. Main, Michaela N. Rechdan, Stefanie Assakawa, Brad E. Hoffman
Publikováno v:
The Journal of Immunology. 208:60.17-60.17
Neuromyelitis optica (NMO) is an auto-inflammatory demyelinating disease that typically affects optic nerves and spinal cord that is characterized by the presence of serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). NMO accounts for >45% of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d664caa6c1593edbdd05fd2192e45058
https://doi.org/10.4049/jimmunol.208.supp.60.17
https://doi.org/10.4049/jimmunol.208.supp.60.17
Autor:
Addelynn Sonia Sagadevan, Geoffrey D. Keeler, Cristina D. Gaddie, Isabelle Cote, Kevin G Senior, Daniel Min, Brad E. Hoffman
Publikováno v:
The Journal of Immunology. 208:60.01-60.01
To re-establish long-term immune tolerance in Multiple Sclerosis (MS), our lab had previously developed a pre-clinical Adeno-associated virus (AAV) gene immunotherapy that is capable of preventing and reversing Myelin Oligodendrocyte Glycoprotein (MO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45e54ca9bb2387be645dc0888f51f95a
https://doi.org/10.4049/jimmunol.208.supp.60.01
https://doi.org/10.4049/jimmunol.208.supp.60.01
Publikováno v:
The Journal of Immunology. 200:121.16-121.16
Autoimmune disease is caused by a breakdown of tolerance against endogenous protein(s). New therapies are being developed that utilize the natural abilities of regulatory T (Treg) cells to suppress autoimmune effector cells in an antigen-specific man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2af06b06096084f6a9cd3215a533c22
https://doi.org/10.4049/jimmunol.200.supp.121.16
https://doi.org/10.4049/jimmunol.200.supp.121.16
Publikováno v:
The Journal of Immunology. 200:121.17-121.17
Similar to Multiple Sclerosis, EAE is a complex disease in which immune tolerance is lost and antigen specific (Ag-sp) Tregs are known to play a role. We have developed a gene immunotherapy that has been shown to induce MOG specific Tregs, restore to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7282eaa87c61942d4cdc0e47ddb0a38e
https://doi.org/10.4049/jimmunol.200.supp.121.17
https://doi.org/10.4049/jimmunol.200.supp.121.17